EC 1.1.1.248: salutaridine reductase (NADPH)
OxidoreductasesOpen in Browse
CatLog read 50 records for EC 1.1.1.248 from 2 papers, for 1 organism. Names in these papers: salutaridine reductase (SalR).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 5 records for EC 1.1.1.248 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.248 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis | Papaver bracteatum | 32 |
| Molecular modeling and site-directed mutagenesis reveal the benzylisoquinoline binding site of the short-chain dehydrogenase/reductase salutaridine reductase | Papaver bracteatum | 18 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| salutaridine reductase (SalR) | Papaver bracteatum | (7S)-salutaridinol | 21.6 | 0.0015 | 1.44 × 10⁴ | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR), (7S)-salutaridinol |
| salutaridine reductase (SalR) | Papaver bracteatum | NADH | 3.7 | 1.19 | 3.1 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR), NADH |
| salutaridine reductase (SalR) | Papaver bracteatum | NADP+ | 21.9 | 0.007 | 3128 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR), NADP+ |
| salutaridine reductase (SalR) | Papaver bracteatum | NADPH | 2.1 | 0.0035 | 600 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR), NADPH |
| salutaridine reductase (SalR) | Papaver bracteatum | NADPH | — | 0.0035 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR), NADPH |
| salutaridine reductase (SalR) | Papaver bracteatum | salutaridine | 2.3 | 0.0079 | 291 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR), salutaridine |
| salutaridine reductase (SalR) | Papaver bracteatum | salutaridine | 1.306 | 0.0021 | 661.7 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR), salutaridine |
| salutaridine reductase (SalR)variant D107A | Papaver bracteatum | NADPH | — | 0.0305 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant D107A, NADPH |
| salutaridine reductase (SalR)variant D107A | Papaver bracteatum | salutaridine | 0.61 | 0.0148 | 41.7 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant D107A, salutaridine |
| salutaridine reductase (SalR)variant F104A | Papaver bracteatum | NADPH | — | 0.0097 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant F104A, NADPH |
| salutaridine reductase (SalR)variant F104A | Papaver bracteatum | salutaridine | 4.5 | 0.0525 | 86 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant F104A, salutaridine |
| salutaridine reductase (SalR)variant F104A | Papaver bracteatum | salutaridine | 2.727 | 0.0318 | 86.2 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant F104A, salutaridine |
| salutaridine reductase (SalR)variant F104A/I275A | Papaver bracteatum | NADPH | — | 0.043 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant F104A/I275A, NADPH |
| salutaridine reductase (SalR)variant F104A/I275A | Papaver bracteatum | salutaridine | 2.45 | 0.4086 | 5.9 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant F104A/I275A, salutaridine |
| salutaridine reductase (SalR)variant I275A | Papaver bracteatum | NADPH | — | 0.0211 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant I275A, NADPH |
| salutaridine reductase (SalR)variant I275A | Papaver bracteatum | salutaridine | 3.188 | 0.0331 | 98 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant I275A, salutaridine |
| salutaridine reductase (SalR)variant I275V | Papaver bracteatum | NADPH | — | 0.0047 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant I275V, NADPH |
| salutaridine reductase (SalR)variant I275V | Papaver bracteatum | salutaridine | 1.022 | 0.0021 | 568.5 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant I275V, salutaridine |
| salutaridine reductase (SalR)variant K186V | Papaver bracteatum | NADPH | — | 0.0034 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant K186V, NADPH |
| salutaridine reductase (SalR)variant K186V | Papaver bracteatum | salutaridine | 0.998 | 0.0078 | 149.3 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant K186V, salutaridine |
| salutaridine reductase (SalR)variant L185A | Papaver bracteatum | NADPH | — | 0.0297 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185A, NADPH |
| salutaridine reductase (SalR)variant L185A | Papaver bracteatum | salutaridine | 0.016 | 0.0132 | 1.2 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185A, salutaridine |
| salutaridine reductase (SalR)variant L185S | Papaver bracteatum | NADPH | — | 0.0129 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185S, NADPH |
| salutaridine reductase (SalR)variant L185S | Papaver bracteatum | salutaridine | 0.148 | 0.0011 | 137.9 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185S, salutaridine |
| salutaridine reductase (SalR)variant L185V | Papaver bracteatum | NADPH | — | 0.0142 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185V, NADPH |
| salutaridine reductase (SalR)variant L185V | Papaver bracteatum | salutaridine | 0.685 | 0.0021 | 347.6 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L185V, salutaridine |
| salutaridine reductase (SalR)variant L266A | Papaver bracteatum | NADPH | — | 0.0155 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L266A, NADPH |
| salutaridine reductase (SalR)variant L266A | Papaver bracteatum | salutaridine | 1.3 | 0.096 | 13 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant L266A, salutaridine |
| salutaridine reductase (SalR)variant L266A | Papaver bracteatum | salutaridine | 0.501 | 0.0494 | 10.2 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant L266A, salutaridine |
| salutaridine reductase (SalR)variant L266S | Papaver bracteatum | salutaridine | 1.1 | 0.0983 | 11 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant L266S, salutaridine |
| salutaridine reductase (SalR)variant L266V | Papaver bracteatum | salutaridine | 1.8 | 0.0445 | 40 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant L266V, salutaridine |
| salutaridine reductase (SalR)variant M271A | Papaver bracteatum | NADPH | — | 0.0198 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant M271A, NADPH |
| salutaridine reductase (SalR)variant M271A | Papaver bracteatum | salutaridine | 0.006 | 0.0225 | 0.3 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant M271A, salutaridine |
| salutaridine reductase (SalR)variant N152A | Papaver bracteatum | salutaridine | 0.36 | 0.0079 | 46 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant N152A, salutaridine |
| salutaridine reductase (SalR)variant N272A | Papaver bracteatum | NADPH | — | 0.0156 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant N272A, NADPH |
| salutaridine reductase (SalR)variant N272A | Papaver bracteatum | salutaridine | 0.021 | 0.0901 | 0.2 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant N272A, salutaridine |
| salutaridine reductase (SalR)variant R44E | Papaver bracteatum | NADH | 5.8 | 1.257 | 4.6 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R44E, NADH |
| salutaridine reductase (SalR)variant R44E | Papaver bracteatum | NADPH | 0.7 | 0.187 | 3.7 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R44E, NADPH |
| salutaridine reductase (SalR)variant R48E | Papaver bracteatum | NADH | 1.7 | 0.884 | 1.9 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R48E, NADH |
| salutaridine reductase (SalR)variant R48E | Papaver bracteatum | NADPH | 3.5 | 0.104 | 33.6 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R48E, NADPH |
| salutaridine reductase (SalR)variant R48K | Papaver bracteatum | NADH | 2.8 | 0.645 | 4.3 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R48K, NADH |
| salutaridine reductase (SalR)variant R48K | Papaver bracteatum | NADPH | 2.2 | 0.0094 | 234 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant R48K, NADPH |
| salutaridine reductase (SalR)variant S180A | Papaver bracteatum | salutaridine | 0.0025 | 0.0253 | 0.099 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant S180A, salutaridine |
| salutaridine reductase (SalR)variant S181A | Papaver bracteatum | NADPH | — | 0.0045 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant S181A, NADPH |
| salutaridine reductase (SalR)variant S181A | Papaver bracteatum | salutaridine | 1.933 | 0.005 | 430.3 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant S181A, salutaridine |
| salutaridine reductase (SalR)variant T182A | Papaver bracteatum | NADPH | — | 0.0213 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant T182A, NADPH |
| salutaridine reductase (SalR)variant T182A | Papaver bracteatum | salutaridine | 0.126 | 0.0041 | 32.4 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant T182A, salutaridine |
| salutaridine reductase (SalR)variant V106A | Papaver bracteatum | NADPH | — | 0.007 | — | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant V106A, NADPH |
| salutaridine reductase (SalR)variant V106A | Papaver bracteatum | salutaridine | 4.5 | 0.0094 | 479 | 30 °C | PMID 17337529 | Open record: salutaridine reductase (SalR) variant V106A, salutaridine |
| salutaridine reductase (SalR)variant V106A | Papaver bracteatum | salutaridine | 2.458 | 0.0089 | 295.4 | pH 6, 30 °C | PMID 19648114 | Open record: salutaridine reductase (SalR) variant V106A, salutaridine |