EC 1.14.15.22: vitamin D 1,25-hydroxylase
OxidoreductasesOpen in Browse
CatLog read 3 records for EC 1.14.15.22 from 1 paper, for 1 organism. Names in these papers: CYP105A1.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 1.14.15.22 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.15.22 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis | Streptomyces griseolus | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| CYP105A1variant R73V/R84A | Streptomyces griseolus | 1alpha,25-dihydroxyvitamin D3 | 8.5 × 10⁻⁴ | 0.0012 | 0.72 | pH 7.4, 30 °C | PMID 20731719 | Open record: CYP105A1 variant R73V/R84A, 1alpha,25-dihydroxyvitamin D3 |
| CYP105A1variant R73V/R84A | Streptomyces griseolus | 1alpha-hydroxyvitamin D3 | 0.0353 | 0.0065 | 5.5 | PMID 20731719 | Open record: CYP105A1 variant R73V/R84A, 1alpha-hydroxyvitamin D3 | |
| CYP105A1variant R73V/R84A | Streptomyces griseolus | vitamin D3 | 0.00235 | 0.0035 | 0.67 | PMID 20731719 | Open record: CYP105A1 variant R73V/R84A, vitamin D3 |