EC 1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase
OxidoreductasesOpen in Browse
CatLog read 32 records for EC 1.3.1.48 from 4 papers, for 4 organisms. Names in these papers: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 15-oxoprostaglandin 13-reductase (PGR), 15-oxoprostaglandin-Δ13-reductase (PGR-2), leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase (gpLTB4 12-HD/PGR).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 43 records for EC 1.3.1.48 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.3.1.48 in Browse.
Papers
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | 15-oxoprostaglandin E1purified from pig lung (native enzyme) | 1.517 | 0.0077 | 200 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), 15-oxoprostaglandin E1 |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | 15-oxoprostaglandin E1recombinant | 1.402 | 0.0083 | 170 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), 15-oxoprostaglandin E1 |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | 15-oxoprostaglandin E2purified from pig lung (native enzyme) | 0.517 | 0.019 | 27 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), 15-oxoprostaglandin E2 |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | 15-oxoprostaglandin E2recombinant | 0.513 | 0.0182 | 28.2 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), 15-oxoprostaglandin E2 |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | leukotriene B4 | 0.005 | 0.01 | 0.50 calc. | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), leukotriene B4 | |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | NADHpurified from pig lung (native enzyme) | 1.45 | 0.153 | 9.48 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), NADH |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | NADHrecombinant | 1.385 | 0.16 | 8.7 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), NADH |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | NADPHpurified from pig lung (native enzyme) | 0.45 | 0.015 | 30 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), NADPH |
| 15-oxoprostaglandin 13-reductase (PGR) | Sus scrofa (pig) | NADPHrecombinant | 0.507 | 0.016 | 32 calc. | pH 7.4, 37 °C | PMID 9461497 | Open record: 15-oxoprostaglandin 13-reductase (PGR), NADPH |
| 15-oxoprostaglandin-Δ13-reductase (PGR-2) | Mus musculus | 15-keto-prostaglandin E1 | 0.123 | 0.0344 | 3.585 | pH 7.4, 37 °C | PMID 17449869 | Open record: 15-oxoprostaglandin-Δ13-reductase (PGR-2), 15-keto-prostaglandin E1 |
| 15-oxoprostaglandin-Δ13-reductase (PGR-2) | Mus musculus | 15-keto-prostaglandin E2 | 0.19 | 0.0496 | 3.83 | pH 7.4, 37 °C | PMID 17449869 | Open record: 15-oxoprostaglandin-Δ13-reductase (PGR-2), 15-keto-prostaglandin E2 |
| 15-oxoprostaglandin-Δ13-reductase (PGR-2) | Mus musculus | 15-keto-prostaglandin F1α | 0.22 | 0.0592 | 3.715 | pH 7.4, 37 °C | PMID 17449869 | Open record: 15-oxoprostaglandin-Δ13-reductase (PGR-2), 15-keto-prostaglandin F1α |
| 15-oxoprostaglandin-Δ13-reductase (PGR-2) | Mus musculus | 15-keto-prostaglandin F2α | 0.247 | 0.1088 | 2.267 | pH 7.4, 37 °C | PMID 17449869 | Open record: 15-oxoprostaglandin-Δ13-reductase (PGR-2), 15-keto-prostaglandin F2α |
| 15-oxoprostaglandin-Δ13-reductase (PGR-2) | Mus musculus | NADPH | 0.155 | 0.0946 | 1.638 | pH 7.4, 37 °C | PMID 17449869 | Open record: 15-oxoprostaglandin-Δ13-reductase (PGR-2), NADPH |
| leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase (gpLTB4 12-HD/PGR) | Cavia porcellus (guinea-pig) | 15-keto-prostaglandin E2 | — | 0.035 | — | pH 7.4, 37 °C | PMID 11733004 | Open record: leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase (gpLTB4 12-HD/PGR), 15-keto-prostaglandin E2 |
| leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase (gpLTB4 12-HD/PGR) | Cavia porcellus (guinea-pig) | leukotriene B4, 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid | — | 0.093 | — | PMID 11733004 | Open record: leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase (gpLTB4 12-HD/PGR), leukotriene B4, 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid | |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | 1,3-diphenylprop-2-en-1-one | 32.3 | 0.18 | 180 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 1,3-diphenylprop-2-en-1-one |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | 3-Nonen-2-one | 19.8 | 0.016 | 1.22 × 10³ | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 3-Nonen-2-one |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | 3-Penten-2-one | 18.5 | 0.49 | 38 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 3-Penten-2-one |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | 4-Hydroxy-2-hexenal | 13.38 | 0.21 | 63 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 4-Hydroxy-2-hexenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | 4-phenylbut-3-en-2-one | 54.7 | 0.039 | 1.4 × 10³ | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), 4-phenylbut-3-en-2-one |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | but-2-enal | 8.05 | 3.9 | 2 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), but-2-enal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | but-3-en-2-one | 156.2 | 0.58 | 270 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), but-3-en-2-one |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | Cinnamaldehyde | 15.7 | 0.075 | 200 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), Cinnamaldehyde |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans,trans-2,4-Nonadienal | 17.2 | 0.41 | 42 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans,trans-2,4-Nonadienal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Decenal | 70.8 | 0.04 | 1.8 × 10³ | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Decenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Dodecenal | 60.2 | 0.06 | 1 × 10³ | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Dodecenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Hexenal | 28.8 | 1 | 28 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Hexenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Nonenal | 94.5 | 0.046 | 2 × 10³ | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Nonenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Octenal | 89.7 | 0.36 | 250 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Octenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | trans-2-Pentenal | 16.8 | 2.4 | 7 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), trans-2-Pentenal |
| NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase) | Rattus norvegicus | α-Methylcinnamaldehyde | 13.1 | 1.7 | 7.8 | pH 7.1, 30 °C | PMID 11524419 | Open record: NAD(P)H-dependent alkenal/one oxidoreductase (AO; DIG-1, leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase), α-Methylcinnamaldehyde |