EC 1.5.1.1: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
OxidoreductasesOpen in Browse
CatLog read 48 records for EC 1.5.1.1 from 3 papers, for 5 organisms. Names in these papers: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), CpLhpI (Δ1-pyrroline-2-carboxylate reductase), PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 13 records for EC 1.5.1.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.5.1.1 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria | Azospirillum brasilense, Colwellia psychrerythraea and 1 more | 23 |
| Ornithine cyclodeaminase/μ-crystallin homolog from the hyperthermophilic archaeon Thermococcus litoralis functions as a novel Δ(1)-pyrroline-2-carboxylate reductase involved in putative… | Thermococcus litoralis | 21 |
| The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of… | Pseudomonas putida | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | L-pipecolatecosubstrate NADP+ | 2.5 | 6.54 | 0.383 | pH 10.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), L-pipecolate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | L-pipecolatecosubstrate NAD+ | 3.7 | 14.8 | 0.25 | pH 10.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), L-pipecolate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | L-prolinecosubstrate NADP+ | 3.92 | 3.63 | 1.083 | pH 10.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), L-proline |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | L-prolinecosubstrate NAD+ | 4.23 | 3.99 | 1.06 | pH 10.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), L-proline |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | Δ1-piperidine-2-carboxylatecosubstrate NADPH | 165.8 | 0.474 | 351.7 | pH 6.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), Δ1-piperidine-2-carboxylate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | Δ1-piperidine-2-carboxylatecosubstrate NADH | 161.5 | 0.6 | 270 | pH 6.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), Δ1-piperidine-2-carboxylate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | Δ1-pyrroline-2-carboxylatecosubstrate NADPH | 523 | 0.628 | 835 | pH 6.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), Δ1-pyrroline-2-carboxylate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | Δ1-pyrroline-2-carboxylatecosubstrate NADH | 615 | 0.837 | 735 | pH 6.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), Δ1-pyrroline-2-carboxylate |
| AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase) | Azospirillum brasilense | Δ1-pyrroline-4S-hydroxy-2-carboxylate | 10.35 | 0.491 | 21.17 | pH 6.5, 30 °C | PMID 24649405 | Open record: AbLhpI (Δ1-pyrroline-2-carboxylate reductase, Pyr2C/Pip2C reductase), Δ1-pyrroline-4S-hydroxy-2-carboxylate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | L-pipecolate | 0.0213 | 80.1 | 2.7 × 10⁻⁴ | pH 10.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), L-pipecolate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | L-prolinecosubstrate NADP+ | 1.088 | 18.3 | 0.0595 | pH 10.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), L-proline |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | L-prolinecosubstrate NAD+ | 0.00692 | 18.8 | 3.7 × 10⁻⁴ | pH 10.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), L-proline |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | Δ1-piperidine-2-carboxylatecosubstrate NADPH | 1.382 | 7.26 | 0.19 | pH 6.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), Δ1-piperidine-2-carboxylate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | Δ1-piperidine-2-carboxylatecosubstrate NADH | 0.0878 | 2.1 | 0.0418 | pH 6.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), Δ1-piperidine-2-carboxylate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | Δ1-pyrroline-2-carboxylatecosubstrate NADPH | 124.5 | 5.9 | 21.17 | pH 6.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), Δ1-pyrroline-2-carboxylate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | Δ1-pyrroline-2-carboxylatecosubstrate NADH | 10.35 | 2.79 | 3.75 | pH 6.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), Δ1-pyrroline-2-carboxylate |
| CpLhpI (Δ1-pyrroline-2-carboxylate reductase) | Colwellia psychrerythraea | Δ1-pyrroline-4S-hydroxy-2-carboxylate | 1.022 | 8.28 | 0.1238 | pH 6.5, 30 °C | PMID 24649405 | Open record: CpLhpI (Δ1-pyrroline-2-carboxylate reductase), Δ1-pyrroline-4S-hydroxy-2-carboxylate |
| DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase) | Pseudomonas putida | L-proline | — | 144 | — | pH 10, 30 °C | PMID 15561717 | Open record: DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase), L-proline |
| DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase) | Pseudomonas putida | NADP+ | — | 0.211 | — | pH 10, 30 °C | PMID 15561717 | Open record: DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase), NADP+ |
| DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase) | Pseudomonas putida | NADPH | — | 0.034 | — | pH 7, 30 °C | PMID 15561717 | Open record: DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase), NADPH |
| DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase) | Pseudomonas putida | Δ1-pyrroline-2-carboxylate | — | 0.043 | — | pH 7, 30 °C | PMID 15561717 | Open record: DpkA (Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase), Δ1-pyrroline-2-carboxylate |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | L-pipecolate | 2.25 | 34.8 | 0.0647 | pH 10, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), L-pipecolate |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | L-proline | 3.42 | 18.5 | 0.185 | pH 10, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), L-proline |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | trans-3-hydroxy-L-proline | 4.53 | 132 | 0.0345 | pH 10, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), trans-3-hydroxy-L-proline |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | Δ1-piperidine-2-carboxylate | 35.3 | 1.57 | 22.5 | pH 7, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), Δ1-piperidine-2-carboxylate |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | Δ1-pyrroline-2-carboxylate | 41.7 | 0.447 | 93.3 | pH 7, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), Δ1-pyrroline-2-carboxylate |
| PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog) | Pseudomonas aeruginosa | Δ1-pyrroline-4S-hydroxy-2-carboxylate | 14.47 | 0.835 | 17.38 | pH 7, 30 °C | PMID 24649405 | Open record: PaLhpD (Δ1-pyrroline-2-carboxylate reductase, dpkA homolog), Δ1-pyrroline-4S-hydroxy-2-carboxylate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | 2-Oxobutyrate | 1.533 | 0.701 | 2.18 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), 2-Oxobutyrate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | 2-Oxovalerate | 2.53 | 0.969 | 2.62 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), 2-Oxovalerate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | 4-Methyl-2-oxovalerate | 2.15 | 2.52 | 0.857 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), 4-Methyl-2-oxovalerate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | ammonium | 4.45 | 1.45 × 10³ | 0.00305 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), ammonium |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-2-aminobutyrate | 0.1118 | 6 | 0.0187 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-2-aminobutyrate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-2-aminovalerate | 0.1093 | 0.306 | 0.358 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-2-aminovalerate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-alanine | 0.044 | 18.2 | 0.00245 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-alanine |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-leucine | 0.175 | 1.32 | 0.133 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-leucine |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-pipecolate | 0.203 | 0.608 | 0.338 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-pipecolate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-prolineNAD+-dependent oxidation; 1.5 mM NAD+; cosubstrate NAD+ | 0.23 | 1.12 | 0.205 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-proline |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | L-prolineNAD(P)H formation at 340 nm; cosubstrate NADP+ | 0.0545 | 13.1 | 0.00417 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), L-proline |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | N-methyl-L-alanine | 0.193 | 0.406 | 0.477 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), N-methyl-L-alanine |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | oxaloacetate | 3.2 | 8.86 | 0.362 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), oxaloacetate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | Pyruvate | 5.25 | 9.37 | 0.56 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), Pyruvate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) | Thermococcus litoralis | Δ1-pyrroline-2-carboxylate | 16.58 | 0.944 | 17.63 | pH 6, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog), Δ1-pyrroline-2-carboxylate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | 2-Oxovalerate | 3.53 | 1.82 | 1.93 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, 2-Oxovalerate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | L-2-aminovalerate | 0.1287 | 2.13 | 0.0607 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, L-2-aminovalerate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | L-alanine | 0.0353 | 36.9 | 9.58 × 10⁻⁴ | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, L-alanine |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | L-proline | 0.608 | 0.444 | 1.37 | pH 10.5, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, L-proline |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | Pyruvate | 6.88 | 62 | 0.1113 | pH 8, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, Pyruvate |
| TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog)variant V224D/A228K | Thermococcus litoralis | Δ1-pyrroline-2-carboxylate | 558 | 2.77 | 215 | pH 6, 50 °C | PMID 25161870 | Open record: TlLhpI (Δ1-pyrroline-2-carboxylate reductase; OCD/μ-crystallin homolog) variant V224D/A228K, Δ1-pyrroline-2-carboxylate |