EC 2.1.1.359: [histone H3]-lysine36 N-trimethyltransferase
TransferasesOpen in Browse
CatLog read 30 records for EC 2.1.1.359 from 2 papers, for 1 organism. Names in these papers: PRDM9, PRDM9 (PR domain-containing protein 9, histone methyltransferase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 2.1.1.359 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.359 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein | Homo sapiens | 16 |
| PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase | Homo sapiens | 14 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 1-25 peptide, dimethylated Lys-4 (H3K4me2) | 5 | 0.003 | 1.7 × 10³ | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 1-25 peptide, dimethylated Lys-4 (H3K4me2) |
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 1-25 peptide, monomethylated Lys-4 (H3K4me1) | 4.17 | 0.001 | 4.2 × 10³ | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 1-25 peptide, monomethylated Lys-4 (H3K4me1) |
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 1-25 peptide, unmodified Lys-4 (H3K4me0) | 5.28 | 0.001 | 5.3 × 10³ | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 1-25 peptide, unmodified Lys-4 (H3K4me0) |
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 21-44 peptide, dimethylated Lys-36 (H3K36me2) | 5.28 | 0.0025 | 2.1 × 10³ | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 21-44 peptide, dimethylated Lys-36 (H3K36me2) |
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 21-44 peptide, monomethylated Lys-36 (H3K36me1) | 1.4 | 0.0024 | 578 | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 21-44 peptide, monomethylated Lys-36 (H3K36me1) |
| PRDM9 | Homo sapiens | biotinylated histone H3 residues 21-44 peptide, unmodified Lys-36 (H3K36me0) | 2.08 | 0.0015 | 1.4 × 10³ | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, biotinylated histone H3 residues 21-44 peptide, unmodified Lys-36 (H3K36me0) |
| PRDM9 | Homo sapiens | H3-H4 tetramer (native) | 1.14 | 7 × 10⁻⁴ | 1628 | pH 8.5 | PMID 24634223 | Open record: PRDM9, H3-H4 tetramer (native) |
| PRDM9 | Homo sapiens | H3-H4 tetramer (truncated H3, lacking first 11 residues) | 1.2 | 0.0014 | 853 | pH 8.5 | PMID 24634223 | Open record: PRDM9, H3-H4 tetramer (truncated H3, lacking first 11 residues) |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(1–25) K4me0 peptide | — | 0.12 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(1–25) K4me1 peptide | — | 0.17 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(1–25) K4me2 peptide | — | 0.14 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(21–44) K36me0 peptide | — | 0.087 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(21–44) K36me1 peptide | — | 0.13 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethioninecosubstrate H3-(21–44) K36me2 peptide | — | 0.062 | — | pH 8.5, 23 °C | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethionine4.5 µM native; (native) | — | 0.24 | — | pH 8.5 | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 | Homo sapiens | S-adenosylmethionine6.5 µM truncated; (truncated H3, lacking first 11 residues) | — | 0.24 | — | pH 8.5 | PMID 24634223 | Open record: PRDM9, S-adenosylmethionine |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) | 7.36 | 0.005 | 1.5 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) | 5.42 | 0.006 | 900 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) | 8.42 | 0.004 | 2.1 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) | 2 | 7 × 10⁻⁴ | 2.9 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) | 9.7 | 0.015 | 650 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) | 4.92 | 0.003 | 1.6 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | S-adenosylmethionine | 3 | 0.024 | 120 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, S-adenosylmethionine |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) | 1.9 × 10⁻⁴ | 4 × 10⁻⁴ | 0.49 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) | 2.2 × 10⁻⁴ | 1 × 10⁻⁴ | 2.2 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) | 1.7 × 10⁻⁴ | 1 × 10⁻⁴ | 1.7 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) | 1.1 × 10⁻⁴ | 3 × 10⁻⁴ | 0.37 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) | 5.6 × 10⁻⁴ | 0.003 | 0.19 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) | 1.4 × 10⁻⁴ | 5 × 10⁻⁴ | 0.28 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | S-adenosylmethionine | 2.2 × 10⁻⁴ | 0.008 | 0.028 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, S-adenosylmethionine |