CatLogenzyme kinetics catalog

EC 2.3.1.21: carnitine O-palmitoyltransferase

TransferasesOpen in Browse

CatLog read 72 records for EC 2.3.1.21 from 4 papers, for 3 organisms. Names in these papers: carnitine palmitoyltransferase I, liver isotype (L-CPTI), carnitine palmitoyltransferase I, liver isoform (L-CPT I), carnitine palmitoyltransferase II (CPT II), liver-type carnitine palmitoyltransferase I (L-CPT I) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 71 records for EC 2.3.1.21 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.21 in Browse.

Papers

PaperOrganismsRecords
Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivityRattus norvegicus, Sus scrofa22
Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase IRattus norvegicus18
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibitionRattus norvegicus16
Cardiolipin Stabilizes and Increases Catalytic Efficiency of Carnitine Palmitoyltransferase II and Its Variants S113L, P50H, and Y479FHomo sapiens16

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant A478GRattus norvegicusL-carnitine—0.327—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant A478GRattus norvegicuspalmitoyl-CoA—0.0151—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant C608ARattus norvegicusL-carnitine—0.0516—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant C608ARattus norvegicuspalmitoyl-CoA—0.0243—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593ARattus norvegicusL-carnitine—0.0563—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593ARattus norvegicuspalmitoyl-CoA—0.0061—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593ERattus norvegicusL-carnitine—0.15—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593ERattus norvegicuspalmitoyl-CoA—0.0063—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593SRattus norvegicusL-carnitine—0.124—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant M593SRattus norvegicuspalmitoyl-CoA—0.0074—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant N464DRattus norvegicusL-carnitine—0.0695—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant N464DRattus norvegicuspalmitoyl-CoA—0.0041—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant T314SRattus norvegicusL-carnitine—0.0882—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant T314SRattus norvegicuspalmitoyl-CoA—0.0017—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant T314S/N464D/A478G/M593S/C608A (QM)Rattus norvegicusL-carnitine—0.0957—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isoform (L-CPT I)variant T314S/N464D/A478G/M593S/C608A (QM)Rattus norvegicuspalmitoyl-CoA—0.0046—30 °CPMID 12499375Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Pig/Rat chimera—L-carnitine—0.1476—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Pig/Rat chimera—palmitoyl-CoA—0.0315—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig chimera—L-carnitine—0.1046—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig chimera—palmitoyl-CoA—0.052—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-A chimera—L-carnitine—0.107—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-A chimera—palmitoyl-CoA—0.06—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-B chimera—L-carnitine—0.111—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-B chimera—palmitoyl-CoA—0.0433—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-C chimera—L-carnitine—0.1107—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rat/Pig-C chimera—palmitoyl-CoA—0.0451—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Δ18 Pig/Rat chimera—L-carnitine—0.1236—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Δ18 Pig/Rat chimera—palmitoyl-CoA—0.0497—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Δ28 Pig/Rat chimera—L-carnitine—0.1017—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Δ28 Pig/Rat chimera—palmitoyl-CoA—0.0474—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rattus norvegicusL-carnitine—0.1003—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Rattus norvegicuspalmitoyl-CoA—0.043—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Sus scrofaL-carnitine—0.1263—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)Sus scrofapalmitoyl-CoA—0.0354—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)variant Δ18Sus scrofaL-carnitine—0.0827—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)variant Δ18Sus scrofapalmitoyl-CoA—0.063—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)variant Δ28Sus scrofaL-carnitine—0.097—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase I, liver isotype (L-CPTI)variant Δ28Sus scrofapalmitoyl-CoA—0.0618—pH 7, 30 °CPMID 11790778Open
carnitine palmitoyltransferase II (CPT II)Homo sapiensL-carnitinewithout cardiolipin (CL)148.615.19.8pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)Homo sapiensL-carnitinewith 0.25 mM cardiolipin (CL)129.95.523.6pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)Homo sapienspalmitoyl-coenzyme Awithout cardiolipin (CL)144.70.00712.05 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)Homo sapienspalmitoyl-coenzyme Awith 0.25 mM cardiolipin (CL)145.30.00672.18 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant P50HHomo sapiensL-carnitinewithout cardiolipin (CL)137.712.810.8pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant P50HHomo sapiensL-carnitinewith 0.25 mM cardiolipin (CL)138.16.621pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant P50HHomo sapienspalmitoyl-coenzyme Awithout cardiolipin (CL)144.30.00552.64 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant P50HHomo sapienspalmitoyl-coenzyme Awith 0.25 mM cardiolipin (CL)138.20.00672.07 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant S113LHomo sapiensL-carnitinewithout cardiolipin (CL)14415.59.3pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant S113LHomo sapiensL-carnitinewith 0.25 mM cardiolipin (CL)135.26.520.7pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant S113LHomo sapienspalmitoyl-coenzyme Awithout cardiolipin (CL)142.10.0111.29 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant S113LHomo sapienspalmitoyl-coenzyme Awith 0.25 mM cardiolipin (CL)145.80.01231.19 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant Y479FHomo sapiensL-carnitinewithout cardiolipin (CL)140.517.48.1pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant Y479FHomo sapiensL-carnitinewith 0.25 mM cardiolipin (CL)138.74.530.9pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant Y479FHomo sapienspalmitoyl-coenzyme Awithout cardiolipin (CL)141.40.00512.75 × 10⁴pH 7.4, 25 °CPMID 34063237Open
carnitine palmitoyltransferase II (CPT II)variant Y479FHomo sapienspalmitoyl-coenzyme Awith 0.25 mM cardiolipin (CL)144.80.00672.17 × 10⁴pH 7.4, 25 °CPMID 34063237Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3ARattus norvegicuscarnitine—0.211—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3ARattus norvegicuspalmitoyl-CoA—0.0786—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3A/Δ(19–30)Rattus norvegicuscarnitine—0.232—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3A/Δ(19–30)Rattus norvegicuspalmitoyl-CoA—0.0577—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3A/Δ(19–46)Rattus norvegicuscarnitine—0.215—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant E3A/Δ(19–46)Rattus norvegicuspalmitoyl-CoA—0.0869—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(19–30)Rattus norvegicuscarnitine—0.259—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(19–30)Rattus norvegicuspalmitoyl-CoA—0.0742—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(19–46)Rattus norvegicuscarnitine—0.232—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(19–46)Rattus norvegicuspalmitoyl-CoA—0.0992—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(1–82)Rattus norvegicuscarnitine—0.483—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(1–82)Rattus norvegicuspalmitoyl-CoA—0.0352—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(3–18)Rattus norvegicuscarnitine—0.227—30 °CPMID 10969089Open
liver-type carnitine palmitoyltransferase I (L-CPT I)variant Δ(3–18)Rattus norvegicuspalmitoyl-CoA—0.0815—30 °CPMID 10969089Open
muscle-type carnitine palmitoyltransferase I (M-CPT I)variant Δ(1–80)Rattus norvegicuscarnitine—0.641—30 °CPMID 10969089Open
muscle-type carnitine palmitoyltransferase I (M-CPT I)variant Δ(1–80)Rattus norvegicuspalmitoyl-CoA—0.1002—30 °CPMID 10969089Open
muscle-type carnitine palmitoyltransferase I (M-CPT I)variant Δ(3–18)Rattus norvegicuscarnitine—1.71—30 °CPMID 10969089Open
muscle-type carnitine palmitoyltransferase I (M-CPT I)variant Δ(3–18)Rattus norvegicuspalmitoyl-CoA—0.0412—30 °CPMID 10969089Open