CatLogenzyme kinetics catalog

EC 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

TransferasesOpen in Browse

CatLog read 16 records for EC 2.7.4.24 from 2 papers, for 2 organisms. Names in these papers: diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2), VIP1, VIP2.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 3 records for EC 2.7.4.24 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.4.24 in Browse.

Papers

PaperOrganismsRecords
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesHomo sapiens, Mus musculus8
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environmentHomo sapiens8

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiens1,5-bis-diphosphoinositol 2,3,4,6-tetrakisphosphate0.192.2 × 10⁻⁵8.5 × 10³pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiens1-diphosphoinositol 2,3,4,5,6-pentakisphosphate0.0021.1 × 10⁻⁴17pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiens5-diphosphoinositol 1,2,3,4,6-pentakisphosphate0.136 × 10⁻⁵2.2 × 10³pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiensADPInsP8 fixed at 10 μM; cosubstrate InsP8—0.90.21pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiensADP1-InsP7 fixed at 10 μM; cosubstrate 1-InsP7—0.00520.37pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiensATPInsP6 fixed at 10 μM; cosubstrate InsP6—0.0370.79pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiensATP5-InsP7 fixed at 10 μM; cosubstrate 5-InsP7—0.0225.9pH 7.2, 37 °CPMID 23240582Open
diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2)Homo sapiensinositol hexakisphosphate0.033.9 × 10⁻⁴76pH 7.2, 37 °CPMID 23240582Open
VIP1Homo sapiens5-diphosphoinositol pentakisphosphatefull-length hsVIP1 (residues 1-1433)4 × 10⁻⁴1 × 10⁻⁴3.9pH 6.2, 37 °CPMID 17690096Open
VIP1Homo sapiens5-diphosphoinositol pentakisphosphatekinase domain hsVIP1-KD; residues 1-3870.001231.2 × 10⁻⁴10.3pH 6.2, 37 °CPMID 17690096Open
VIP1Homo sapiensinositol hexakisphosphatefull-length hsVIP1 (residues 1-1433)1.1 × 10⁻⁴1.2 × 10⁻⁴0.88pH 6.2, 37 °CPMID 17690096Open
VIP1Homo sapiensinositol hexakisphosphatekinase domain hsVIP1-KD; residues 1-3875 × 10⁻⁴1.2 × 10⁻⁴4.1pH 6.2, 37 °CPMID 17690096Open
VIP2Homo sapiens5-diphosphoinositol pentakisphosphate0.00381.9 × 10⁻⁴20.4pH 6.2, 37 °CPMID 17690096Open
VIP2Homo sapiensinositol hexakisphosphate0.001061.3 × 10⁻⁴8pH 6.2, 37 °CPMID 17690096Open
VIP2Mus musculus5-diphosphoinositol pentakisphosphate0.01635.4 × 10⁻⁴30.1pH 6.2, 37 °CPMID 17690096Open
VIP2Mus musculusinositol hexakisphosphate0.00532.3 × 10⁻⁴23.4pH 6.2, 37 °CPMID 17690096Open