EC 3.1.1.43: alpha-amino-acid esterase
HydrolasesOpen in Browse
CatLog read 29 records for EC 3.1.1.43 from 3 papers, for 3 organisms. Names in these papers: α-amino ester hydrolase (AEH), alpha-amino acid ester hydrolase (AEH), human valacyclovirase (hVACVase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 15 records for EC 3.1.1.43 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.43 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| doi:10.1016/j.cej.2021.131816 | Xanthomonas campestris pv. campestris | 15 |
| Cloning, sequence analysis, and expression in Escherichia coli of the gene encoding an alpha-amino acid ester hydrolase from Acetobacter turbidans | Acetobacter turbidans | 8 |
| Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect | Homo sapiens | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | amoxicillin | 10 | 2.6 | 3.9 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), amoxicillin |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | ampicillin | 162 | 1 | 162 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), ampicillin |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | cefadroxil | 9.6 | 1.7 | 6 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), cefadroxil |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | cephalexin | 347 | 0.34 | 1021 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), cephalexin |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | D-2-nitro-5-[(phenylglycyl)amino]benzoic acid | 0.4 | 1.1 | 0.4 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), D-2-nitro-5-[(phenylglycyl)amino]benzoic acid |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | D-4-hydroxyphenylglycine methyl ester | 263 | 11 | 24 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), D-4-hydroxyphenylglycine methyl ester |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | D-phenylglycine amide | — | — | 3.3 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), D-phenylglycine amide |
| alpha-amino acid ester hydrolase (AEH) | Acetobacter turbidans | D-phenylglycine methyl ester | 1035 | 7 | 148 | pH 6.2, 30 °C | PMID 11772629 | Open record: alpha-amino acid ester hydrolase (AEH), D-phenylglycine methyl ester |
| human valacyclovirase (hVACVase) | Homo sapiens | (2S)-2-amino-3-methyl-N-[3-[(aminoiminomethyl)amino]phenyl]methylbutanamide | 0.00229 | 1.81 | 0.00126 | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), (2S)-2-amino-3-methyl-N-[3-[(aminoiminomethyl)amino]phenyl]methylbutanamide |
| human valacyclovirase (hVACVase) | Homo sapiens | L-phenylalanine benzyl ester | 395 | 0.099 | 3.98 × 10³ | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), L-phenylalanine benzyl ester |
| human valacyclovirase (hVACVase) | Homo sapiens | L-phenylalanine ethyl ester | 93 | 6.7 | 14 | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), L-phenylalanine ethyl ester |
| human valacyclovirase (hVACVase) | Homo sapiens | L-phenylalanine methyl ester | 228 | 5.14 | 44 | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), L-phenylalanine methyl ester |
| human valacyclovirase (hVACVase) | Homo sapiens | L-valine benzyl ester | 60 | 0.06 | 992 | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), L-valine benzyl ester |
| human valacyclovirase (hVACVase) | Homo sapiens | L-valine p-nitrobenzyl ester | 130 | 0.014 | 9.49 × 10³ | pH 7.4, 37 °C | PMID 21028903 | Open record: human valacyclovirase (hVACVase), L-valine p-nitrobenzyl ester |
| α-amino ester hydrolase (AEH) | Xanthomonas campestris pv. campestris | (R)-(4-hydroxyphenyl)glycine methyl ester | 44 | 26 | 1.7 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH), (R)-(4-hydroxyphenyl)glycine methyl ester |
| α-amino ester hydrolase (AEH) | Xanthomonas campestris pv. campestris | (R)-phenylglycine methyl ester | 970 | 3.5 | 280 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH), (R)-phenylglycine methyl ester |
| α-amino ester hydrolase (AEH) | Xanthomonas campestris pv. campestris | Amoxicillin | 0.51 | 12 | 0.04 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH), Amoxicillin |
| α-amino ester hydrolase (AEH) | Xanthomonas campestris pv. campestris | Cefadroxil | 3.5 | 15 | 0.23 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH), Cefadroxil |
| α-amino ester hydrolase (AEH) | Xanthomonas campestris pv. campestris | Cephalexin | 200 | 1.9 | 100 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH), Cephalexin |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143G | Xanthomonas campestris pv. campestris | (R)-(4-hydroxyphenyl)glycine methyl ester | 100 | 29 | 3.5 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143G, (R)-(4-hydroxyphenyl)glycine methyl ester |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143G | Xanthomonas campestris pv. campestris | (R)-phenylglycine methyl ester | 1.1 × 10³ | 5.9 | 180 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143G, (R)-phenylglycine methyl ester |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143G | Xanthomonas campestris pv. campestris | Amoxicillin | 1.5 | 5 | 0.3 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143G, Amoxicillin |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143G | Xanthomonas campestris pv. campestris | Cefadroxil | 6 | 15 | 0.41 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143G, Cefadroxil |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143G | Xanthomonas campestris pv. campestris | Cephalexin | 280 | 1.4 | 210 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143G, Cephalexin |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143H | Xanthomonas campestris pv. campestris | (R)-(4-hydroxyphenyl)glycine methyl ester | 67 | 20 | 3.4 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143H, (R)-(4-hydroxyphenyl)glycine methyl ester |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143H | Xanthomonas campestris pv. campestris | (R)-phenylglycine methyl ester | 770 | 3.7 | 210 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143H, (R)-phenylglycine methyl ester |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143H | Xanthomonas campestris pv. campestris | Amoxicillin | 1 | 8.7 | 0.1 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143H, Amoxicillin |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143H | Xanthomonas campestris pv. campestris | Cefadroxil | 4.5 | 16 | 0.28 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143H, Cefadroxil |
| α-amino ester hydrolase (AEH)variant N186D/A275P/V622I/E143H | Xanthomonas campestris pv. campestris | Cephalexin | 230 | 1.6 | 140 | pH 7, 25 °C | doi:10.1016/j.cej.2021.131816 | Open record: α-amino ester hydrolase (AEH) variant N186D/A275P/V622I/E143H, Cephalexin |