CatLogenzyme kinetics catalog

EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

HydrolasesOpen in Browse

CatLog read 45 records for EC 3.2.2.6 from 2 papers, for 2 organisms. Names in these papers: CD38, CD38/NAD+ glycohydrolase (bCD38).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 14 records for EC 3.2.2.6 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.2.2.6 in Browse.

Papers

PaperOrganismsRecords
A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activitiesHomo sapiens33
Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residuesBos taurus12

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CD38Homo sapienscyclic ADP-ribose—0.42—pH 7.8PMID 11278881Open
CD38Homo sapiensNAD—0.048—pH 7.8PMID 11278881Open
CD38Homo sapiensNADP—0.02—pH 4.5PMID 11278881Open
CD38Homo sapiensnicotinamide guanine dinucleotide—0.004—pH 7.8PMID 11278881Open
CD38variant E146AHomo sapienscyclic ADP-ribose—0.14—pH 7.8PMID 11278881Open
CD38variant E146AHomo sapiensNAD—0.019—pH 7.8PMID 11278881Open
CD38variant E146AHomo sapiensNAD—0.03—pH 7.8PMID 11278881Open
CD38variant E146AHomo sapiensNADP—0.047—pH 4.5PMID 11278881Open
CD38variant E146AHomo sapiensnicotinamide guanine dinucleotide—0.053—pH 7.8PMID 11278881Open
CD38variant E146DHomo sapiensNAD—0.008—pH 7.8PMID 11278881Open
CD38variant E146DHomo sapiensNAD—0.027—pH 7.8PMID 11278881Open
CD38variant E146DHomo sapiensNADP—0.008—pH 4.5PMID 11278881Open
CD38variant E146DHomo sapiensnicotinamide guanine dinucleotide—0.036—pH 7.8PMID 11278881Open
CD38variant E146FHomo sapienscyclic ADP-ribose—0.17—pH 7.8PMID 11278881Open
CD38variant E146FHomo sapiensNAD—0.019—pH 7.8PMID 11278881Open
CD38variant E146FHomo sapiensNAD—0.062—pH 7.8PMID 11278881Open
CD38variant E146FHomo sapiensNADP—0.16—pH 4.5PMID 11278881Open
CD38variant E146FHomo sapiensnicotinamide guanine dinucleotide—0.125—pH 7.8PMID 11278881Open
CD38variant E146GHomo sapienscyclic ADP-ribose—0.42—pH 7.8PMID 11278881Open
CD38variant E146GHomo sapiensNAD—0.006—pH 7.8PMID 11278881Open
CD38variant E146GHomo sapiensNAD—0.051—pH 7.8PMID 11278881Open
CD38variant E146GHomo sapiensNADP—0.036—pH 4.5PMID 11278881Open
CD38variant E146GHomo sapiensnicotinamide guanine dinucleotide—0.078—pH 7.8PMID 11278881Open
CD38variant E146LHomo sapienscyclic ADP-ribose—0.52—pH 7.8PMID 11278881Open
CD38variant E146LHomo sapiensNAD—0.012—pH 7.8PMID 11278881Open
CD38variant E146LHomo sapiensNAD—0.017—pH 7.8PMID 11278881Open
CD38variant E146LHomo sapiensNADP—0.113—pH 4.5PMID 11278881Open
CD38variant E146LHomo sapiensnicotinamide guanine dinucleotide—0.211—pH 7.8PMID 11278881Open
CD38variant E146NHomo sapienscyclic ADP-ribose—0.21—pH 7.8PMID 11278881Open
CD38variant E146NHomo sapiensNAD—0.022—pH 7.8PMID 11278881Open
CD38variant E146NHomo sapiensNAD—0.042—pH 7.8PMID 11278881Open
CD38variant E146NHomo sapiensNADP—0.082—pH 4.5PMID 11278881Open
CD38variant E146NHomo sapiensnicotinamide guanine dinucleotide—0.091—pH 7.8PMID 11278881Open
CD38/NAD+ glycohydrolase (bCD38)Bos taurusNAD+57.90.01713.38 × 10³pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant D147ABos taurusNAD+3.50.0175200pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant E138ABos taurusNAD+0.810.027629.3pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant E138QBos taurusNAD+6.640.0295220pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant E218ABos taurusNAD+0.01550.0280.55pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant E218QBos taurusNAD+0.030.02471.21pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W118ABos taurusNAD+0.1220.01896.4pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W118A/W181ABos taurusNAD+0.0160.02970.544pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W118FBos taurusNAD+10.360.036290pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W118HBos taurusNAD+18.370.0289630pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W181ABos taurusNAD+0.490.045310.8pH 7.4, 37 °CPMID 24721563Open
CD38/NAD+ glycohydrolase (bCD38)variant W181FBos taurusNAD+7.80.0215360pH 7.4, 37 °CPMID 24721563Open