EC 3.4.21.104: mannan-binding lectin-associated serine protease-2

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CatLog read 16 records for EC 3.4.21.104 from 3 papers, for 1 organism. Names in these papers: mannan-binding lectin-associated serine protease-2 (MASP-2), MASP-2 (MBL-associated serine protease-2), MASP-2 (mannan-binding lectin-associated serine protease-2).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 5 records for EC 3.4.21.104 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.104 in Browse.

Papers

Papers with records for EC 3.4.21.104
Paper	Organisms	Records
Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2	Homo sapiens	8
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor	Homo sapiens	6
Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement…	Homo sapiens	2

Records

Records for EC 3.4.21.104 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
mannan-binding lectin-associated serine protease-2 (MASP-2)	Homo sapiens	human complement component C2 (purified from human plasma)	4.9	0.0065	750	pH 7.4, 37 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2), human complement component C2 (purified from human plasma)
mannan-binding lectin-associated serine protease-2 (MASP-2)	Homo sapiens	human complement component C4 (purified from human plasma)	2.2	7.4 × 10⁻⁵	2.97 × 10⁴	pH 7.4, 37 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2), human complement component C4 (purified from human plasma)
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	human complement component C2 (purified from human plasma)	7.4	0.0066	1.12 × 10³	pH 7.4, 37 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, human complement component C2 (purified from human plasma)
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	human complement component C4 (purified from human plasma)	3.4	6 × 10⁻⁵	5.67 × 10⁴	pH 7.4, 37 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, human complement component C4 (purified from human plasma)
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	N-acetylglycyl-L-lysine methyl ester	133	6.7	19.8	30 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, N-acetylglycyl-L-lysine methyl ester
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	N-benzyloxycarbonylglycyl-L-arginine thiobenzyl ester	12.7	0.04	318	30 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, N-benzyloxycarbonylglycyl-L-arginine thiobenzyl ester
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	Nalpha-benzoyl-L-arginine ethyl ester	2.4	4.4	0.54	30 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, Nalpha-benzoyl-L-arginine ethyl ester
mannan-binding lectin-associated serine protease-2 (MASP-2)CCP1/2-SP fragment	Homo sapiens	p-tosyl-L-arginine methyl ester	7.1	2.8	2.5	30 °C	PMID 11527969	Open record: mannan-binding lectin-associated serine protease-2 (MASP-2) CCP1/2-SP fragment, p-tosyl-L-arginine methyl ester
MASP-2 (mannan-binding lectin-associated serine protease-2)	Homo sapiens	complement component C2	5.6	0.0052	1.08 × 10³		PMID 16227207	Open record: MASP-2 (mannan-binding lectin-associated serine protease-2), complement component C2
MASP-2 (mannan-binding lectin-associated serine protease-2)	Homo sapiens	complement component C4	1.9	8.5 × 10⁻⁵	2.23 × 10⁴		PMID 16227207	Open record: MASP-2 (mannan-binding lectin-associated serine protease-2), complement component C4
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	2Abz-GLQRALEI-Lys(Dnp)-NH2	9.35	—	—	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), 2Abz-GLQRALEI-Lys(Dnp)-NH2
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	2Abz-SLGRKIQI-Lys(Dnp)-NH2	99.58	—	—	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), 2Abz-SLGRKIQI-Lys(Dnp)-NH2
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	2Abz-SVARTLLV-Lys(Dnp)-NH2	35.32	—	—	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), 2Abz-SVARTLLV-Lys(Dnp)-NH2
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	C1-Inh P4-P1 peptide substrate	0.25	0.123	2	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), C1-Inh P4-P1 peptide substrate
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	C2 P4-P1 peptide substrate	31.86	0.0152	2.1 × 10³	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), C2 P4-P1 peptide substrate
MASP-2 (MBL-associated serine protease-2)	Homo sapiens	C4 P4-P1 peptide substrate	4.54	0.0155	290	37 °C	PMID 17709141	Open record: MASP-2 (MBL-associated serine protease-2), C4 P4-P1 peptide substrate