CatLogenzyme kinetics catalog

EC 3.4.21.108: HtrA2 peptidase

HydrolasesOpen in Browse

CatLog read 10 records for EC 3.4.21.108 from 2 papers, for 1 organism. Names in these papers: HtrA2, HtrA2 (high-temperature requirement protease A2, mitochondrial serine protease Omi).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 14 records for EC 3.4.21.108 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.108 in Browse.

Papers

PaperOrganismsRecords
Design and synthesis of new substrates of HtrA2 proteaseHomo sapiens6
Dual regulatory switch confers tighter control on HtrA2 proteolytic activityHomo sapiens4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-threonyl-L-2-aminobutyryl-L-tyrosyl-L-methionyl-L-histidyl-3-nitro-L-tyrosinamide0.22——pH 8PMID 25640585Open
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-threonyl-L-2-aminobutyryl-L-tyrosyl-L-methionyl-L-phenylalanyl-3-nitro-L-tyrosinamide0.33——pH 8PMID 25640585Open
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-threonyl-L-2-aminobutyryl-L-tyrosyl-L-methionyl-L-tryptophyl-3-nitro-L-tyrosinamide0.17——pH 8PMID 25640585Open
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-threonyl-L-seryl-L-tyrosyl-L-methionyl-L-phenylalanyl-3-nitro-L-tyrosinamide0.010.35430.028pH 8PMID 25640585Open
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-valyl-L-2-aminobutyryl-L-tyrosyl-L-methionyl-L-phenylalanyl-3-nitro-L-tyrosinamide0.130.03154.117pH 8PMID 25640585Open
HtrA2Homo sapiens2-aminobenzoyl-L-isoleucyl-L-methionyl-L-valyl-L-seryl-L-tyrosyl-L-methionyl-L-phenylalanyl-3-nitro-L-tyrosinamide0.080.17730.681pH 8PMID 25640585Open
HtrA2 (high-temperature requirement protease A2, mitochondrial serine protease Omi)variant G230AHomo sapiensfluorescein isothiocyanate-labelled beta-caseinno activator—0.00320.16pH 7.8, 37 °CPMID 24698088Open
HtrA2 (high-temperature requirement protease A2, mitochondrial serine protease Omi)variant G230AHomo sapiensfluorescein isothiocyanate-labelled beta-casein—0.00350.26pH 7.8, 37 °CPMID 24698088Open
HtrA2 (high-temperature requirement protease A2, mitochondrial serine protease Omi)variant G230AHomo sapiensfluorescein isothiocyanate-labelled beta-casein—0.00320.44pH 7.8, 37 °CPMID 24698088Open
HtrA2 (high-temperature requirement protease A2, mitochondrial serine protease Omi)variant G230AHomo sapiensfluorescein isothiocyanate-labelled beta-casein—0.0030.51pH 7.8, 37 °CPMID 24698088Open