EC 3.4.21.37: leukocyte elastase
HydrolasesOpen in Browse
CatLog read 48 records for EC 3.4.21.37 from 3 papers, for 1 organism. Names in these papers: human leukocyte elastase (HLE; human neutrophil elastase), human leukocyte elastase (HLE), human neutrophil elastase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 14 records for EC 3.4.21.37 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.37 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase | Homo sapiens | 34 |
| Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements | Homo sapiens | 13 |
| Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates | Homo sapiens | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide | 22 | 0.833 | 26.9 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine thiobenzyl ester | 53 | 0.013 | 4.1 × 10³ | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine thiobenzyl ester |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alpha-aminobutyric acid p-nitroanilide | 20 | 0.24 | 80 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-alpha-aminobutyric acid p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-valine p-nitroanilide | 10 | 0.055 | 182 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-valine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-valine thiobenzyl ester | 13 | 0.0023 | 5.6 × 10³ | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-alanyl-L-prolyl-L-valine thiobenzyl ester |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide | 7 | 1.5 | 4.5 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-prolyl-L-alanine thiobenzyl ester | 46 | 0.012 | 3.84 × 10³ | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-prolyl-L-alanine thiobenzyl ester |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-prolyl-L-valine p-nitroanilide | 10 | 0.189 | 56 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-prolyl-L-valine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-alanyl-L-prolyl-L-valine thiobenzyl ester | 13 | 0.0023 | 5.6 × 10³ | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-alanyl-L-prolyl-L-valine thiobenzyl ester |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-prolyl-L-valine p-nitroanilide | 0.4 | 0.696 | 0.575 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-prolyl-L-valine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-prolyl-L-valine thiobenzyl ester | 11 | 0.012 | 880 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-prolyl-L-valine thiobenzyl ester |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-valine p-nitroanilide | 0.06 | 0.788 | 0.075 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-valine p-nitroanilide |
| human leukocyte elastase (HLE) | Homo sapiens | N-methoxysuccinyl-L-valine thiobenzyl ester | 10 | 0.015 | 680 | pH 7.4, 25 °C | PMID 3646070 | Open record: human leukocyte elastase (HLE), N-methoxysuccinyl-L-valine thiobenzyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl ester | — | 0.035 | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl ester | 120 | — | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl ester | — | — | 3.4 × 10³ | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl esterwith 0.35 mM decanol | — | 0.364 | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl esterwith 0.35 mM decanol | 4.5 × 10³ | — | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl esterwith 0.35 mM decanol | — | — | 1.2 × 10⁴ | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-(p-toluenesulfonyl)alanine p-nitrophenyl ester | 120 | 0.028 | 4.2 × 10³ | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-(p-toluenesulfonyl)alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole | 16 | 0.022 | 720 | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole | 20 | 0.017 | 1.2 × 10³ | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole | 18 | 0.016 | 1.1 × 10³ | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine p-nitrophenyl ester | 28 | 0.056 | 500 | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine p-nitrophenyl ester | 46 | 0.065 | 720 | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-benzyloxycarbonyl-alanine p-nitrophenyl ester | 36 | 0.046 | 760 | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-benzyloxycarbonyl-alanine p-nitrophenyl ester |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | 0.016 | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | 140 | — | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | — | 8.9 × 10³ | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | 0.054 | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | 4.5 × 10³ | — | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | — | 8.4 × 10⁴ | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM ethanol | — | 0.014 | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM ethanol | 28 | — | — | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM ethanol | — | — | 2.1 × 10³ | pH 7 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | 0.026 | — | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | 110 | — | — | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | — | 4.2 × 10³ | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | 0.067 | — | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | 4.8 × 10³ | — | — | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | — | 7.1 × 10⁴ | pH 8 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | 0.016 | — | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | 96 | — | — | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole | — | — | 6.1 × 10³ | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | 0.08 | — | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | 4.2 × 10³ | — | — | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human leukocyte elastase (HLE; human neutrophil elastase) | Homo sapiens | N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrolewith 0.35 mM decanol | — | — | 5.2 × 10⁴ | pH 9 | PMID 7487054 | Open record: human leukocyte elastase (HLE; human neutrophil elastase), N-tosyl-L-alanine ester of 3-hydroxy-5-phenylpyrrole |
| human neutrophil elastase | Homo sapiens | O-aminobenzoyl-Gly-Ile-Ala-Thr-Phe-Cys-Asp-Leu-Met-Pro-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 1.1 × 10³ | 37 °C | PMID 21599834 | Open record: human neutrophil elastase, O-aminobenzoyl-Gly-Ile-Ala-Thr-Phe-Cys-Asp-Leu-Met-Pro-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |