EC 3.4.24.18: meprin A

HydrolasesOpen in Browse

CatLog read 36 records for EC 3.4.24.18 from 4 papers, for 2 organisms. Names in these papers: meprin-A, meprin A, meprin α.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 9 records for EC 3.4.24.18 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.18 in Browse.

Papers

Papers with records for EC 3.4.24.18
Paper	Organisms	Records
Mapping the active site of meprin-A with peptide substrates and inhibitors	Mus musculus	27
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity	Mus musculus	7
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis	Homo sapiens	1
A kinetic comparison of the homologous proteases astacin and meprin A	Mus musculus	1

Records

Records for EC 3.4.24.18 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
meprin A	Mus musculus	gastrin-releasing peptide fragment 14-27	88.3	0.116	761	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, gastrin-releasing peptide fragment 14-27
meprin A	Mus musculus	Glucagon	17.4	0.223	78	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, Glucagon
meprin A	Mus musculus	human secretin	11.8	0.217	54.4	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, human secretin
meprin A	Mus musculus	Neuropeptide Y	—	—	32.3	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, Neuropeptide Y
meprin A	Mus musculus	Substance P	27.8	0.118	236	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, Substance P
meprin A	Mus musculus	succinyl-Ala-Ala-Ala-p-nitroanilide	—	—	0.231	pH 8.7, 30 °C	PMID 8161197	Open record: meprin A, succinyl-Ala-Ala-Ala-p-nitroanilide
meprin A	Mus musculus	sulfated cholecystokinin octapeptide amide (DY(SO3H)MGWMDF-NH2)	42.3	0.356	118	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, sulfated cholecystokinin octapeptide amide (DY(SO3H)MGWMDF-NH2)
meprin A	Mus musculus	Valosin	18.8	0.12	157	pH 7.5, 37 °C	PMID 11278902	Open record: meprin A, Valosin
meprin α	Homo sapiens	Lys-Lys-Gly-Tyr-Val-Ala-Asp-Ala-Pro-p-nitroanilide	1	0.024	57	pH 7.4, 30 °C	PMID 30098994	Open record: meprin α, Lys-Lys-Gly-Tyr-Val-Ala-Asp-Ala-Pro-p-nitroanilide
meprin-A	Mus musculus	2-aminobenzoyl-Arg-[hydroxyproline]-Gly-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg	26.7	0.183	146	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-[hydroxyproline]-Gly-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg	1.1	0.22	4.81	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-[4-nitrophenylalanine]-Arg	98.5	1.38	69.2	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-[4-nitrophenylalanine]-Arg	4.9	1.22	4.05	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-[4-nitrophenylalanine]-Arg	12	2.46	4.87	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-[4-nitrophenylalanine]-Arg	2.4	0.402	6.07	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Gly-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg	81.2	0.366	222	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Gly-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	2-aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg	132.7	0.296	448	pH 8.7	PMID 1883833	Open record: meprin-A, 2-aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-[4-nitrophenylalanine]-Arg
meprin-A	Mus musculus	[Thr6]bradykinin (Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg)	0.4	—	—		PMID 1883833	Open record: meprin-A, [Thr6]bradykinin (Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg)
meprin-A	Mus musculus	acetyl-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val (sequence as printed in Table I)	34.5	—	—		PMID 1883833	Open record: meprin-A, acetyl-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val (sequence as printed in Table I)
meprin-A	Mus musculus	Arg-Pro-(hydroxyproline)-Gly-Phe-Ser-Pro-Phe-Arg ([Hyp3]bradykinin)	2.4	—	—		PMID 1883833	Open record: meprin-A, Arg-Pro-(hydroxyproline)-Gly-Phe-Ser-Pro-Phe-Arg ([Hyp3]bradykinin)
meprin-A	Mus musculus	Arg-Pro-Pro-Gly-(4-chlorophenylalanine)-Ser-Pro-(4-chlorophenylalanine)-Arg	26.6	—	—		PMID 1883833	Open record: meprin-A, Arg-Pro-Pro-Gly-(4-chlorophenylalanine)-Ser-Pro-(4-chlorophenylalanine)-Arg
meprin-A	Mus musculus	Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Ala-Pro-Phe-Arg	51.5	0.331	156	pH 8.7	PMID 1883833	Open record: meprin-A, Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Ala-Pro-Phe-Arg
meprin-A	Mus musculus	Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Arg-Pro-Phe-Arg	19.6	0.174	113	pH 8.7	PMID 1883833	Open record: meprin-A, Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Arg-Pro-Phe-Arg
meprin-A	Mus musculus	Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Lys-Pro-Phe-Arg	5	0.182	27.5	pH 8.7	PMID 1883833	Open record: meprin-A, Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Lys-Pro-Phe-Arg
meprin-A	Mus musculus	Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Phe-Pro-Phe-Arg	7.6	0.226	33.4	pH 8.7	PMID 1883833	Open record: meprin-A, Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Phe-Pro-Phe-Arg
meprin-A	Mus musculus	Arg-Val-Tyr-Ile-His-Pro-Phe (sequence as printed in Table I)	0.1	—	—		PMID 1883833	Open record: meprin-A, Arg-Val-Tyr-Ile-His-Pro-Phe (sequence as printed in Table I)
meprin-A	Mus musculus	Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu (sequence as printed in Table I)	0.14	—	—		PMID 1883833	Open record: meprin-A, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu (sequence as printed in Table I)
meprin-A	Mus musculus	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe (sequence as printed in Table I)	0.15	—	—		PMID 1883833	Open record: meprin-A, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe (sequence as printed in Table I)
meprin-A	Mus musculus	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu (sequence as printed in Table I)	0.64	—	—		PMID 1883833	Open record: meprin-A, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu (sequence as printed in Table I)
meprin-A	Mus musculus	bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg)	22	—	—		PMID 1883833	Open record: meprin-A, bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg)
meprin-A	Mus musculus	D-Arg-Arg-Pro-(hydroxyproline)-Gly-(thienylalanine)-Ser-D-Phe-(thienylalanine)-Arg	0.2	—	—		PMID 1883833	Open record: meprin-A, D-Arg-Arg-Pro-(hydroxyproline)-Gly-(thienylalanine)-Ser-D-Phe-(thienylalanine)-Arg
meprin-A	Mus musculus	des-Pro2-bradykinin (Arg-Pro-Gly-Phe-Ser-Pro-Phe-Arg)	63.7	—	—		PMID 1883833	Open record: meprin-A, des-Pro2-bradykinin (Arg-Pro-Gly-Phe-Ser-Pro-Phe-Arg)
meprin-A	Mus musculus	Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (sequence as printed in Table I)	30.4	—	—		PMID 1883833	Open record: meprin-A, Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (sequence as printed in Table I)
meprin-A	Mus musculus	N-acetyl-bradykinin (Ac-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg)	54.3	—	—		PMID 1883833	Open record: meprin-A, N-acetyl-bradykinin (Ac-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg)
meprin-A	Mus musculus	Phe5(4-nitro)bradykinin, nitrobradykinin (Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Ser-Pro-Phe-Arg)	40.9	0.29	141	pH 8.7	PMID 1883833	Open record: meprin-A, Phe5(4-nitro)bradykinin, nitrobradykinin (Arg-Pro-Pro-Gly-[4-nitrophenylalanine]-Ser-Pro-Phe-Arg)
meprin-A	Mus musculus	pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-NH2 (sequence as printed in Table I)	7.6	—	—		PMID 1883833	Open record: meprin-A, pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-NH2 (sequence as printed in Table I)