EC 3.4.24.65: macrophage elastase
HydrolasesOpen in Browse
CatLog read 73 records for EC 3.4.24.65 from 1 paper, for 2 organisms. Names in these papers: MMP-12 (macrophage elastase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 17 records for EC 3.4.24.65 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.65 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| New insights into the substrate specificity of macrophage elastase MMP-12 | Homo sapiens, Mus musculus | 73 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 170 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Asn-Ala-Leu-Ala-Val-Glu-Arg-Thr-Ala-Ser-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 140 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Asn-Ala-Leu-Ala-Val-Glu-Arg-Thr-Ala-Ser-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Gly-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 32 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Gly-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 71 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 730 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 61 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 1.6 × 10³ | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.26 | 0.029 | 9 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 2.4 | 0.0075 | 320 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 82 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 920 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.33 | 0.0144 | 23 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 5.6 | 0.0156 | 359 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 74 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 420 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.17 | 0.0146 | 12 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 1.3 | 0.0123 | 106 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 74 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 560 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.11 | 0.0068 | 17 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 2.8 | 0.0138 | 203 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 37 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 760 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.14 | 0.0093 | 15 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 1.4 | 0.0088 | 159 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 64 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 720 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.19 | 0.0103 | 18 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 3.8 | 0.0197 | 193 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 23 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 310 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 9.3 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 59 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 55 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 700 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Glu-Ala-Ala-Pro-Ser-Ser-Val-Ile-Ala-Ala-Thr-Glu-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 50 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Glu-Ala-Ala-Pro-Ser-Ser-Val-Ile-Ala-Ala-Thr-Glu-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 69 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 620 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 17 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 110 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 3.6 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 280 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 24 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 660 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Arg-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-CAT-MMP-12: catalytic domain only; C-terminal His6-tagged | — | — | 11 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamineh-FL-MMP-12: full-length; commercial (R&D Systems) | — | — | 390 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 27 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 190 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.85 | 0.0202 | 42 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 1.5 | 0.0249 | 60 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 10 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediaminefirst-order conditions (5 µM substrate << Km); Table 2 | — | — | 110 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.29 | 0.0091 | 32 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Homo sapiens | 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamineMichaelis-Menten fit of initial rates at 0.5-20 µM substrate | 0.55 | 0.0047 | 117 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 2 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Ala-Ser-Val-Ala-Thr-Glu-Leu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 7.3 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Arg-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 13 | pH 8, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 6.2 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Glu-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 8.4 | pH 8, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 10 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 7.4 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 145 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Ala-Leu-Trp-Glu-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 6 | pH 8, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 2.3 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Glu-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 8.5 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 2.7 | pH 8, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Gly-Ala-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 3.9 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Arg-Pro-Leu-Gly-Leu-Trp-Gly-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 4.7 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Glu-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 5.9 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Ala-Met-Phe-Leu-Glu-Ala-Ile-Pro-Met-Ser-Ile-Pro-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 3.2 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Glu-Leu-Glu-Glu-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 38 | pH 8, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Gly-Pro-Leu-Gly-Leu-Glu-Arg-Ala-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 7.4 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Ala-Leu-Trp-Arg-Ser-Gln-N-(2,4-dinitrophenyl)ethylenediamine |
| MMP-12 (macrophage elastase) | Mus musculus | 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine | — | — | 6.2 | pH 7.5, 30 °C | PMID 26760307 | Open record: MMP-12 (macrophage elastase), 2-aminobenzoyl-Pro-Leu-Gly-Leu-Glu-Glu-Ala-N-(2,4-dinitrophenyl)ethylenediamine |