EC 3.5.4.31: S-methyl-5'-thioadenosine deaminase
HydrolasesOpen in Browse
CatLog read 47 records for EC 3.5.4.31 from 4 papers, for 7 organisms. Names in these papers: adenosine deaminase (PfADA), 5'-deoxyadenosine deaminase (DadD), adenosine deaminase (PvADA), adenosine deaminase (PbADA) and 3 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 7 records for EC 3.5.4.31 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.5.4.31 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine | Plasmodium falciparum | 18 |
| Identification of a 5'-deoxyadenosine deaminase in Methanocaldococcus jannaschii and its possible role in recycling the radical S-adenosylmethionine enzyme reaction product 5'-deoxyadenosine | Methanocaldococcus jannaschii | 15 |
| Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases | Plasmodium berghei, Plasmodium cynomolgi and 3 more | 13 |
| Structure-based activity prediction for an enzyme of unknown function | Thermotoga maritima | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 5'-deoxyadenosine deaminase (DadD) | Methanocaldococcus jannaschii | 5'-deoxyadenosine | 1.2 × 10⁵ | 0.014 | 9.1 × 10⁶ | pH 9, 60 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD), 5'-deoxyadenosine |
| 5'-deoxyadenosine deaminase (DadD) | Methanocaldococcus jannaschii | 5'-methylthioadenosine | 160 | 0.11 | 1.1 × 10³ | pH 9, 60 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD), 5'-methylthioadenosine |
| 5'-deoxyadenosine deaminase (DadD) | Methanocaldococcus jannaschii | adenosine | 110 | 0.15 | 750 | pH 9, 60 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD), adenosine |
| 5'-deoxyadenosine deaminase (DadD) | Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine | 1.3 × 10³ | 1.1 | 4.4 × 10³ | pH 9, 60 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD), S-adenosyl-L-homocysteine |
| 5'-deoxyadenosine deaminase (DadD)variant E150R | Methanocaldococcus jannaschii | 5'-deoxyadenosine | 210 | 0.021 | 9.8 × 10⁴ | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant E150R, 5'-deoxyadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant E150R | Methanocaldococcus jannaschii | 5'-methylthioadenosine | 200 | 0.048 | 4.2 × 10³ | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant E150R, 5'-methylthioadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant E150R | Methanocaldococcus jannaschii | adenosine | 110 | 0.15 | 750 | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant E150R, adenosine |
| 5'-deoxyadenosine deaminase (DadD)variant E150R | Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine | 58.2 | 3.9 | 21 | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant E150R, S-adenosyl-L-homocysteine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R | Methanocaldococcus jannaschii | 5'-deoxyadenosine | 330 | 0.032 | 1.7 × 10⁴ | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R, 5'-deoxyadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R | Methanocaldococcus jannaschii | 5'-methylthioadenosine | 220 | 0.022 | 1.1 × 10⁴ | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R, 5'-methylthioadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R | Methanocaldococcus jannaschii | adenosine | 140 | 0.072 | 2.9 × 10³ | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R, adenosine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R | Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine | 24.7 | 0.16 | 230 | pH 9, 50 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R, S-adenosyl-L-homocysteine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R/E150R | Methanocaldococcus jannaschii | 5'-deoxyadenosine | 1.12 | 0.05 | 31 | pH 9, 25 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R/E150R, 5'-deoxyadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R/E150R | Methanocaldococcus jannaschii | 5'-methylthioadenosine | 1.39 | 0.073 | 19 | pH 9, 25 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R/E150R, 5'-methylthioadenosine |
| 5'-deoxyadenosine deaminase (DadD)variant Y136R/E150R | Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine | 2.41 | 0.4 | 5.3 | pH 9, 25 °C | PMID 24375099 | Open record: 5'-deoxyadenosine deaminase (DadD) variant Y136R/E150R, S-adenosyl-L-homocysteine |
| adenosine deaminase (PbADA) | Plasmodium berghei | 5'-methylthioadenosine | 0.35 | 0.0044 | 79 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PbADA), 5'-methylthioadenosine |
| adenosine deaminase (PbADA) | Plasmodium berghei | adenosine | 4.7 | 0.057 | 82 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PbADA), adenosine |
| adenosine deaminase (PcADA) | Plasmodium cynomolgi | 5'-methylthioadenosine | 0.31 | 0.0087 | 36 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PcADA), 5'-methylthioadenosine |
| adenosine deaminase (PcADA) | Plasmodium cynomolgi | adenosine | 5.3 | 0.087 | 61 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PcADA), adenosine |
| adenosine deaminase (PfADA) | Plasmodium falciparum | 5'-methylthioadenosine | 5.8 | 0.115 | 50 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PfADA), 5'-methylthioadenosine |
| adenosine deaminase (PfADA) | Plasmodium falciparum | 5′-methylthioadenosine | 13.92 | 0.0306 | 450 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA), 5′-methylthioadenosine |
| adenosine deaminase (PfADA) | Plasmodium falciparum | adenosine | 5.6 | 0.088 | 64 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PfADA), adenosine |
| adenosine deaminase (PfADA) | Plasmodium falciparum | adenosine | 4.1 | 0.01784 | 230 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA), adenosine |
| adenosine deaminase (PfADA)variant C27Q/L227I | Plasmodium falciparum | 5′-methylthioadenosine | 12.17 | 0.04461 | 270 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant C27Q/L227I, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant C27Q/L227I | Plasmodium falciparum | adenosine | 6.16 | 0.02344 | 260 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant C27Q/L227I, adenosine |
| adenosine deaminase (PfADA)variant D176A | Plasmodium falciparum | 5′-methylthioadenosine | 5.49 | 0.2893 | 20 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176A, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant D176A | Plasmodium falciparum | adenosine | 5.59 | 0.1263 | 40 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176A, adenosine |
| adenosine deaminase (PfADA)variant D176A/L179H | Plasmodium falciparum | 5′-methylthioadenosine | 1.75 | 0.2242 | 8 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176A/L179H, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant D176A/L179H | Plasmodium falciparum | adenosine | 0.31 | 0.159 | 2 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176A/L179H, adenosine |
| adenosine deaminase (PfADA)variant D176M | Plasmodium falciparum | 5′-methylthioadenosine | 1.78 | 0.2533 | 7 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176M, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant D176M | Plasmodium falciparum | adenosine | 0.97 | 0.2996 | 3 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant D176M, adenosine |
| adenosine deaminase (PfADA)variant F136L | Plasmodium falciparum | 5′-methylthioadenosine | 0.69 | 0.376 | 2 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant F136L, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant F136L | Plasmodium falciparum | adenosine | 1.31 | 0.3221 | 4 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant F136L, adenosine |
| adenosine deaminase (PfADA)variant L179H | Plasmodium falciparum | 5′-methylthioadenosine | 14.07 | 0.05256 | 270 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant L179H, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant L179H | Plasmodium falciparum | adenosine | 4.41 | 0.02113 | 210 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant L179H, adenosine |
| adenosine deaminase (PfADA)variant T174A | Plasmodium falciparum | 5′-methylthioadenosine | 4.48 | 0.2003 | 20 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant T174A, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant T174A | Plasmodium falciparum | adenosine | 7.45 | 0.04203 | 180 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant T174A, adenosine |
| adenosine deaminase (PfADA)variant T174I | Plasmodium falciparum | 5′-methylthioadenosine | 0.33 | 0.2675 | 1 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant T174I, 5′-methylthioadenosine |
| adenosine deaminase (PfADA)variant T174I | Plasmodium falciparum | adenosine | 2.42 | 0.00943 | 260 | pH 8 | PMID 31002765 | Open record: adenosine deaminase (PfADA) variant T174I, adenosine |
| adenosine deaminase (PkADA) | Plasmodium knowlesi | 5'-methylthioadenosine | 0.51 | 0.022 | 23 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PkADA), 5'-methylthioadenosine |
| adenosine deaminase (PkADA) | Plasmodium knowlesi | adenosine | 6.8 | 0.12 | 57 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PkADA), adenosine |
| adenosine deaminase (PvADA) | Plasmodium vivax | 5'-methylthioadenosine | 0.13 | 0.0095 | 14 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PvADA), 5'-methylthioadenosine |
| adenosine deaminase (PvADA) | Plasmodium vivax | adenosine | 1.8 | 0.06 | 30 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PvADA), adenosine |
| adenosine deaminase (PvADA)variant D172A | Plasmodium vivax | adenosine | 14 | 0.104 | 130 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PvADA) variant D172A, adenosine |
| adenosine deaminase (PvADA)variant D172E | Plasmodium vivax | adenosine | 12.9 | 0.083 | 150 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PvADA) variant D172E, adenosine |
| adenosine deaminase (PvADA)variant ΔAsp172 | Plasmodium vivax | adenosine | 2.8 | 0.043 | 65 | pH 8 | PMID 19728741 | Open record: adenosine deaminase (PvADA) variant ΔAsp172, adenosine |
| Tm0936 | Thermotoga maritima | 5'-S-methyl-5'-thioadenosine | 7.2 | 0.044 | 140 | pH 8, 30 °C | PMID 17603473 | Open record: Tm0936, 5'-S-methyl-5'-thioadenosine |