EC 4.1.1.25: tyrosine decarboxylase
LyasesOpen in Browse
CatLog read 29 records for EC 4.1.1.25 from 4 papers, for 4 organisms. Names in these papers: tyrosine decarboxylase (LbTDC), PcncAAAD (noncanonical aromatic L-amino acid decarboxylase), tyrosine decarboxylase (LbTyDC), paralogous tyrosine decarboxylase pTDC_EFM and 2 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 31 records for EC 4.1.1.25 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.1.25 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding | Lactobacillus brevis | 10 |
| Calcium activation mechanism of a noncanonical aromatic L-amino acid decarboxylase from psilocybin mushroom Psilocybe cubensis | Psilocybe cubensis | 8 |
| Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease | Enterococcus faecalis, Enterococcus faecium | 6 |
| doi:10.1039/c9cy01290g | Lactobacillus brevis | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| paralogous tyrosine decarboxylase pTDC_EFM | Enterococcus faecium | L-3,4-dihydroxyphenylalanine | 5.707 | 0.4 | 12.73 | pH 4.5 | PMID 30659181 | Open record: paralogous tyrosine decarboxylase pTDC_EFM, L-3,4-dihydroxyphenylalanine |
| paralogous tyrosine decarboxylase pTDC_EFM | Enterococcus faecium | L-tyrosine | 7.26 | 0.2 | 42.63 | pH 4.5 | PMID 30659181 | Open record: paralogous tyrosine decarboxylase pTDC_EFM, L-tyrosine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM calcium acetate; 30 nM enzyme | 0.51 | 0.088 | 5.8 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase), L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM NaCl; 150 nM enzyme | 0.074 | 0.064 | 1.2 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase), L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E637A/E638A/D971A/E972A/D973A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM calcium acetate; 30 nM enzyme | 0.073 | 0.513 | 0.14 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E637A/E638A/D971A/E972A/D973A, L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E637A/E638A/D971A/E972A/D973A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM NaCl; 150 nM enzyme | 0.038 | 0.332 | 0.11 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E637A/E638A/D971A/E972A/D973A, L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E637A/E638A/D971A/E972A/D973A/E824A/D825A/D931A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM calcium acetate; 30 nM enzyme | 0.044 | 0.586 | 0.075 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E637A/E638A/D971A/E972A/D973A/E824A/D825A/D931A, L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E637A/E638A/D971A/E972A/D973A/E824A/D825A/D931A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM NaCl; 150 nM enzyme | 0.026 | 0.527 | 0.049 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E637A/E638A/D971A/E972A/D973A/E824A/D825A/D931A, L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E824A/D825A/D931A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM calcium acetate; 30 nM enzyme | 0.41 | 0.174 | 2.4 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E824A/D825A/D931A, L-phenylalanine |
| PcncAAAD (noncanonical aromatic L-amino acid decarboxylase)variant E824A/D825A/D931A | Psilocybe cubensis | L-phenylalanine50 mM Tris pH 8.0 with 30 mM NaCl; 150 nM enzyme | 0.059 | 0.087 | 0.68 calc. | pH 8 | PMID 41748824 | Open record: PcncAAAD (noncanonical aromatic L-amino acid decarboxylase) variant E824A/D825A/D931A, L-phenylalanine |
| tyrosine decarboxylase (LbTDC) | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 76.5 | 0.8 | 101.1 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC), L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase (LbTDC) | Lactobacillus brevis | L-tyrosine | 124.8 | 0.6 | 216 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC), L-tyrosine |
| tyrosine decarboxylase (LbTDC)variant K240A | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 64.7 | 1.1 | 58.3 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant K240A, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase (LbTDC)variant K240A | Lactobacillus brevis | L-tyrosine | 224.5 | 1.6 | 139.4 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant K240A, L-tyrosine |
| tyrosine decarboxylase (LbTDC)variant S586A | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 126 | 0.7 | 181.3 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant S586A, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase (LbTDC)variant S586A | Lactobacillus brevis | L-tyrosine | 250.9 | 0.4 | 600.4 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant S586A, L-tyrosine |
| tyrosine decarboxylase (LbTDC)variant Y398A | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 2.5 | 1.7 | 1.5 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant Y398A, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase (LbTDC)variant Y398A | Lactobacillus brevis | L-tyrosine | 9.8 | 3 | 3.4 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant Y398A, L-tyrosine |
| tyrosine decarboxylase (LbTDC)variant Y398F | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 12.3 | 0.7 | 18.4 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant Y398F, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase (LbTDC)variant Y398F | Lactobacillus brevis | L-tyrosine | 31.9 | 2.4 | 13.5 | pH 5, 40 °C | PMID 27292129 | Open record: tyrosine decarboxylase (LbTDC) variant Y398F, L-tyrosine |
| tyrosine decarboxylase (LbTyDC) | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 159 | 3.72 | 42.9 | doi:10.1039/c9cy01290g | Open record: tyrosine decarboxylase (LbTyDC), L-3,4-dihydroxyphenylalanine | |
| tyrosine decarboxylase (LbTyDC) | Lactobacillus brevis | L-tyrosine | 165 | 1.18 | 140 | doi:10.1039/c9cy01290g | Open record: tyrosine decarboxylase (LbTyDC), L-tyrosine | |
| tyrosine decarboxylase (LbTyDC)variant H241N | Lactobacillus brevis | L-tyrosine | 4.02 | 0.05 | 7.28 | doi:10.1039/c9cy01290g | Open record: tyrosine decarboxylase (LbTyDC) variant H241N, L-tyrosine | |
| tyrosine decarboxylase (LbTyDC)variant H98M | Lactobacillus brevis | L-3,4-dihydroxyphenylalanine | 7.1 | 1.62 | 4.38 | doi:10.1039/c9cy01290g | Open record: tyrosine decarboxylase (LbTyDC) variant H98M, L-3,4-dihydroxyphenylalanine | |
| tyrosine decarboxylase (LbTyDC)variant H98M | Lactobacillus brevis | L-tyrosine | 4.26 | 0.77 | 5.53 | doi:10.1039/c9cy01290g | Open record: tyrosine decarboxylase (LbTyDC) variant H98M, L-tyrosine | |
| tyrosine decarboxylase TDC_EFM | Enterococcus faecium | L-3,4-dihydroxyphenylalanine | 42.48 | 7.2 | 5.87 | pH 5 | PMID 30659181 | Open record: tyrosine decarboxylase TDC_EFM, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase TDC_EFM | Enterococcus faecium | L-tyrosine | 36.73 | 1.5 | 24.88 | pH 5 | PMID 30659181 | Open record: tyrosine decarboxylase TDC_EFM, L-tyrosine |
| tyrosine decarboxylase TDC_EFS | Enterococcus faecalis | L-3,4-dihydroxyphenylalanine | 58.85 | 3 | 19.3 | pH 5 | PMID 30659181 | Open record: tyrosine decarboxylase TDC_EFS, L-3,4-dihydroxyphenylalanine |
| tyrosine decarboxylase TDC_EFS | Enterococcus faecalis | L-tyrosine | 116.0 | 0.6 | 203.6 | pH 5 | PMID 30659181 | Open record: tyrosine decarboxylase TDC_EFS, L-tyrosine |