EC 4.1.1.76: arylmalonate decarboxylase
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CatLog read 43 records for EC 4.1.1.76 from 3 papers, for 1 organism. Names in these papers: aryl/alkenyl malonate decarboxylase (AMDase), arylmalonate decarboxylase (AMDase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 31 records for EC 4.1.1.76 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.1.1.76 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates | Bordetella bronchiseptica | 29 |
| Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism | — | 8 |
| Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution | Bordetella bronchiseptica | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | 277.9 | 8.2 | 33.9 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | 147.7 | 3.1 | 48.3 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | 12.4 | 12.7 | 1 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(furan-2-yl)-2-hydroxypropanedioic acid | 61.9 | 8.6 | 6.4 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(furan-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(furan-2-yl)propanedioic acid | — | 10.1 | — | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(furan-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-(furan-2-yl)propanedioic acidkinetic methods given in the Supporting Information | 188.2 | — | — | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-(furan-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | 30.5 | 16.1 | 1.9 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | 224.8 | 6.4 | 35.3 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | 165.9 | 4.3 | 38.6 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | 37.1 | 9.8 | 3.8 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | |
| aryl/alkenyl malonate decarboxylase (AMDase) | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | 42.4 | 13.3 | 3.2 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase), furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | 182.1 | 3.6 | 50.6 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | 54.8 | 0.82 | 66.6 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | 35 | 11.4 | 3.1 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-(furan-2-yl)-2-hydroxypropanedioic acid | 149.3 | 7.2 | 20.7 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-(furan-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | 35 | 10.7 | 3.2 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | 86.4 | 7.3 | 11.8 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | 79.3 | 3.5 | 22.4 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | 55.9 | 9.5 | 5.9 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant M159V | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | 55.9 | 8.9 | 6.3 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant M159V, furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | 115.3 | 7.4 | 15.6 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-(1-benzofuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | 68.5 | 2.1 | 9.9 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-(1-benzothiophen-5-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | 28.8 | 12.6 | 2.3 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-(4,5-dimethylfuran-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-(furan-2-yl)-2-hydroxypropanedioic acid | 66.4 | 6.9 | 9.6 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-(furan-2-yl)-2-hydroxypropanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | 28.8 | 7.2 | 4.1 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-hydroxy-2-(5-methoxyfuran-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | 42.2 | 13 | 3.2 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-hydroxy-2-(pyridin-3-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | 34 | 2.2 | 15.2 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, 2-hydroxy-2-(thiophen-2-yl)propanedioic acid | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | 35.9 | 7.3 | 4.9 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, furan-2-yl α-hydroxy malonic acid 8 b (furan ring substituent shown only in the structure image) | |
| aryl/alkenyl malonate decarboxylase (AMDase)variant P14V/P15G | Bordetella bronchiseptica | furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | 34 | 9.9 | 3.4 | PMID 25766433 | Open record: aryl/alkenyl malonate decarboxylase (AMDase) variant P14V/P15G, furan-2-yl α-hydroxy malonic acid 8 c (furan ring substituent shown only in the structure image) | |
| arylmalonate decarboxylase (AMDase) | — | 2-methyl-2-(naphthalen-2-yl)propanedioic acid | 31 | 0.43 | 72 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase), 2-methyl-2-(naphthalen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase) | — | 2-methyl-2-(thiophen-2-yl)propanedioic acid | 200 | 12.5 | 16 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase), 2-methyl-2-(thiophen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant C188S | — | 2-methyl-2-(naphthalen-2-yl)propanedioic acid | 2.54 | 1.26 | 2.02 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant C188S, 2-methyl-2-(naphthalen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant C188S | — | 2-methyl-2-(thiophen-2-yl)propanedioic acid | 1.63 | 14.5 | 0.112 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant C188S, 2-methyl-2-(thiophen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant G74C | — | 2-methyl-2-(naphthalen-2-yl)propanedioic acid | 0.5 | 1.56 | 0.32 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant G74C, 2-methyl-2-(naphthalen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant G74C | — | 2-methyl-2-(thiophen-2-yl)propanedioic acid | 0.79 | 6.24 | 0.13 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant G74C, 2-methyl-2-(thiophen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant G74C/C188S | — | 2-methyl-2-(naphthalen-2-yl)propanedioic acid | 0.12 | 1.25 | 0.096 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant G74C/C188S, 2-methyl-2-(naphthalen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase)variant G74C/C188S | — | 2-methyl-2-(thiophen-2-yl)propanedioic acid | 0.34 | 5.03 | 0.068 calc. | PMID 15700067 | Open record: arylmalonate decarboxylase (AMDase) variant G74C/C188S, 2-methyl-2-(thiophen-2-yl)propanedioic acid | |
| arylmalonate decarboxylase (AMDase) | Bordetella bronchiseptica | phenylmalonate | 260 | 5.1 | 50 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase), phenylmalonate | |
| arylmalonate decarboxylase (AMDase)variant G74C/C188G | Bordetella bronchiseptica | phenylmalonate | 0.05 | 3.3 | 0.015 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase) variant G74C/C188G, phenylmalonate | |
| arylmalonate decarboxylase (AMDase)variant G74C/C188S | Bordetella bronchiseptica | phenylmalonate | 0.02 | 7.5 | 0.0027 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase) variant G74C/C188S, phenylmalonate | |
| arylmalonate decarboxylase (AMDase)variant G74C/M159L/C188G | Bordetella bronchiseptica | phenylmalonate | 3.3 | 5.9 | 0.56 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase) variant G74C/M159L/C188G, phenylmalonate | |
| arylmalonate decarboxylase (AMDase)variant Y48F/G74C/C188G | Bordetella bronchiseptica | phenylmalonate | 0.44 | 7.1 | 0.062 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase) variant Y48F/G74C/C188G, phenylmalonate | |
| arylmalonate decarboxylase (AMDase)variant Y48F/G74C/M159L/C188G | Bordetella bronchiseptica | phenylmalonate | 11 | 4.6 | 2.5 | PMID 21559536 | Open record: arylmalonate decarboxylase (AMDase) variant Y48F/G74C/M159L/C188G, phenylmalonate |