EC 4.2.1.52: dihydrodipicolinate synthase
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CatLog read 24 records for EC 4.2.1.52 from 2 papers, for 1 organism. Names in these papers: dihydrodipicolinate synthase (DHDPS).
EC 4.2.1.52 is no longer current; BRENDA: “transferred to EC 4.3.3.7”.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface? | Escherichia coli | 16 |
| The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad | Escherichia coli | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | (S)-aspartate-β-semialdehyde | — | 0.11 | 1.1 × 10³ | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS), (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | (S)-aspartate-β-semialdehydeinitial rates at five concentrations of each substrate | — | 0.13 | 600 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS), (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | (S)-aspartate-β-semialdehyde(S)-lysine inhibition series (0-5.0 mM); (S)-ASA varied | — | 0.09 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS), (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | pyruvate | 124 | 0.26 | 480 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS), pyruvate |
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | pyruvateinitial rates at five concentrations of each substrate | 78 | 0.16 | 488 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS), pyruvate |
| dihydrodipicolinate synthase (DHDPS) | Escherichia coli | pyruvate(S)-lysine inhibition series (0-5.0 mM); pyruvate varied | — | 0.084 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS), pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant D193A | Escherichia coli | (S)-aspartate-β-semialdehydeinitial rates at five concentrations of each substrate | — | 0.17 | 53 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193A, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant D193A | Escherichia coli | (S)-aspartate-β-semialdehyde(S)-lysine inhibition series (0-5.0 mM); (S)-ASA varied | — | 0.11 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193A, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant D193A | Escherichia coli | pyruvateinitial rates at five concentrations of each substrate | 9.15 | 0.44 | 21 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193A, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant D193A | Escherichia coli | pyruvate(S)-lysine inhibition series (0-5.0 mM); pyruvate varied | — | 0.3 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193A, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant D193Y | Escherichia coli | (S)-aspartate-β-semialdehyde | 6.5 | 0.15 | 43 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193Y, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant D193Y | Escherichia coli | pyruvate | 7.2 | 0.57 | 12.6 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant D193Y, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant Q196D | Escherichia coli | (S)-aspartate-β-semialdehydeinitial rates at five concentrations of each substrate | — | 0.15 | 88 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q196D, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant Q196D | Escherichia coli | (S)-aspartate-β-semialdehyde(S)-lysine inhibition series (0-5.0 mM); (S)-ASA varied | — | 0.1 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q196D, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant Q196D | Escherichia coli | pyruvateinitial rates at five concentrations of each substrate | 13.28 | 0.32 | 42 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q196D, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant Q196D | Escherichia coli | pyruvate(S)-lysine inhibition series (0-5.0 mM); pyruvate varied | — | 0.23 | — | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q196D, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant Q234D | Escherichia coli | (S)-aspartate-β-semialdehyde | 12.4 | 0.15 | 83 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q234D, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant Q234D | Escherichia coli | pyruvate | 11.8 | 0.46 | 25.6 | 30 °C | PMID 19919824 | Open record: dihydrodipicolinate synthase (DHDPS) variant Q234D, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant T44V | Escherichia coli | (S)-aspartate-β-semialdehyde | — | 0.09 | 1.3 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant T44V, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant T44V | Escherichia coli | pyruvate | 0.116 | 0.08 | 1.4 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant T44V, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant Y107F | Escherichia coli | (S)-aspartate-β-semialdehyde | — | 0.58 | 19 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant Y107F, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant Y107F | Escherichia coli | pyruvate | 10.8 | 0.16 | 66 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant Y107F, pyruvate |
| dihydrodipicolinate synthase (DHDPS)variant Y133F | Escherichia coli | (S)-aspartate-β-semialdehyde | — | 2.7 | 0.26 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant Y133F, (S)-aspartate-β-semialdehyde |
| dihydrodipicolinate synthase (DHDPS)variant Y133F | Escherichia coli | pyruvate | 0.7 | 35 | 0.02 | pH 8, 30 °C | PMID 15066435 | Open record: dihydrodipicolinate synthase (DHDPS) variant Y133F, pyruvate |