EC 4.2.3.9: aristolochene synthase

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CatLog read 34 records for EC 4.2.3.9 from 5 papers, for 2 organisms. Names in these papers: aristolochene synthase, aristolochene synthase (ATAS), aristolochene synthase (PR-AS).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 26 records for EC 4.2.3.9 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.2.3.9 in Browse.

Papers

Papers with records for EC 4.2.3.9
Paper	Organisms	Records
Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis	Aspergillus terreus, Penicillium roqueforti	14
Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase	Aspergillus terreus	8
The role of aristolochene synthase in diphosphate activation	Penicillium roqueforti	7
Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase	Aspergillus terreus, Penicillium roqueforti	3
Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase	Penicillium roqueforti	2

Records

Records for EC 4.2.3.9 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
aristolochene synthase	Aspergillus terreus	farnesyl diphosphate	0.014	1.35 × 10⁻⁵	1.04 × 10³	pH 7.5, 30 °C	PMID 10775423	Open record: aristolochene synthase, farnesyl diphosphate
aristolochene synthase	Aspergillus terreus	farnesyl diphosphaterecombinant; untagged	0.015	1.48 × 10⁻⁵	1.01 × 10³	pH 7.5, 30 °C	PMID 10775423	Open record: aristolochene synthase, farnesyl diphosphate
aristolochene synthase	Aspergillus terreus	farnesyl diphosphate	0.0173	1.3 × 10⁻⁴	130	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase, farnesyl diphosphate
aristolochene synthasevariant E227D	Aspergillus terreus	farnesyl diphosphate	0.0016	0.0014	1.1	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant E227D, farnesyl diphosphate
aristolochene synthasevariant N219D	Aspergillus terreus	farnesyl diphosphate	7.6 × 10⁻⁵	0.0039	0.0195	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant N219D, farnesyl diphosphate
aristolochene synthase	Penicillium roqueforti	farnesyl diphosphate	0.043	5.2 × 10⁻⁴	82.9	pH 7.5, 30 °C	PMID 10775423	Open record: aristolochene synthase, farnesyl diphosphate
aristolochene synthase	Penicillium roqueforti	farnesyl diphosphate	0.043	6 × 10⁻⁴	72	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase, farnesyl diphosphate
aristolochene synthasevariant D115E	Penicillium roqueforti	farnesyl diphosphate	0.0162	0.0027	6	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant D115E, farnesyl diphosphate
aristolochene synthasevariant D116E	Penicillium roqueforti	farnesyl diphosphate	0.0013	0.0011	1.2	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant D116E, farnesyl diphosphate
aristolochene synthasevariant D116N	Penicillium roqueforti	farnesyl diphosphate	0.0022	0.0015	1.5	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant D116N, farnesyl diphosphate
aristolochene synthasevariant E119D	Penicillium roqueforti	farnesyl diphosphate	0.0097	3.2 × 10⁻⁴	30	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant E119D, farnesyl diphosphate
aristolochene synthasevariant E119Q	Penicillium roqueforti	farnesyl diphosphate	0.0048	1.5 × 10⁻⁴	32	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant E119Q, farnesyl diphosphate
aristolochene synthasevariant E252D	Penicillium roqueforti	farnesyl diphosphate	0.0022	0.0034	0.65	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant E252D, farnesyl diphosphate
aristolochene synthasevariant E252Q	Penicillium roqueforti	farnesyl diphosphate	2.2 × 10⁻⁴	0.0101	0.0218	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant E252Q, farnesyl diphosphate
aristolochene synthasevariant N244D	Penicillium roqueforti	farnesyl diphosphate	1.2 × 10⁻⁴	0.0033	0.0364	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant N244D, farnesyl diphosphate
aristolochene synthasevariant S248A	Penicillium roqueforti	farnesyl diphosphate	0.0013	0.0055	0.24	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant S248A, farnesyl diphosphate
aristolochene synthasevariant Y92A	Penicillium roqueforti	farnesyl pyrophosphate	0.00137	0.0834	0.0165	pH 7.5	PMID 12820883	Open record: aristolochene synthase variant Y92A, farnesyl pyrophosphate
aristolochene synthasevariant Y92C	Penicillium roqueforti	farnesyl pyrophosphate	4.91 × 10⁻⁴	0.05027	0.0102	pH 7.5	PMID 12820883	Open record: aristolochene synthase variant Y92C, farnesyl pyrophosphate
aristolochene synthasevariant Y92F	Penicillium roqueforti	farnesyl diphosphate	4 × 10⁻⁴	1.2 × 10⁻⁵	34	pH 8, 30 °C	PMID 15186158	Open record: aristolochene synthase variant Y92F, farnesyl diphosphate
aristolochene synthase (ATAS)	Aspergillus terreus	farnesyl diphosphate	0.027	9.9 × 10⁻⁵	270	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS), farnesyl diphosphate
aristolochene synthase (ATAS)variant N299A	Aspergillus terreus	farnesyl diphosphate	0.012	4.1 × 10⁻⁴	29	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant N299A, farnesyl diphosphate
aristolochene synthase (ATAS)variant N299A/S303A	Aspergillus terreus	farnesyl diphosphate	0.0058	4.1 × 10⁻⁴	14	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant N299A/S303A, farnesyl diphosphate
aristolochene synthase (ATAS)variant Q151E	Aspergillus terreus	farnesyl diphosphate	0.0015	1 × 10⁻⁴	15	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant Q151E, farnesyl diphosphate
aristolochene synthase (ATAS)variant Q151H	Aspergillus terreus	farnesyl diphosphate	6.3 × 10⁻⁴	4.2 × 10⁻⁵	15	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant Q151H, farnesyl diphosphate
aristolochene synthase (ATAS)variant S303A	Aspergillus terreus	farnesyl diphosphate	0.045	1.2 × 10⁻⁴	370	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant S303A, farnesyl diphosphate
aristolochene synthase (ATAS)variant S303D	Aspergillus terreus	farnesyl diphosphate	4.1 × 10⁻⁴	3.6 × 10⁻⁴	1.1	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant S303D, farnesyl diphosphate
aristolochene synthase (ATAS)variant S303H	Aspergillus terreus	farnesyl diphosphate	0.0013	6.1 × 10⁻⁵	21	pH 8, 30 °C	PMID 27172425	Open record: aristolochene synthase (ATAS) variant S303H, farnesyl diphosphate
aristolochene synthase (PR-AS)	Penicillium roqueforti	farnesyl diphosphate	0.084	5.3 × 10⁻⁴	158.5		PMID 22349314	Open record: aristolochene synthase (PR-AS), farnesyl diphosphate
aristolochene synthase (PR-AS)variant D203L	Penicillium roqueforti	farnesyl diphosphate	7.5 × 10⁻⁴	7.4 × 10⁻⁴	1.013		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant D203L, farnesyl diphosphate
aristolochene synthase (PR-AS)variant K251Q	Penicillium roqueforti	farnesyl diphosphate	0.002	2.4 × 10⁻⁴	8.5		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant K251Q, farnesyl diphosphate
aristolochene synthase (PR-AS)variant K251R	Penicillium roqueforti	farnesyl diphosphate	0.0037	1.4 × 10⁻⁴	26.43		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant K251R, farnesyl diphosphate
aristolochene synthase (PR-AS)variant R200K	Penicillium roqueforti	farnesyl diphosphate	6 × 10⁻⁴	0.00104	0.62		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant R200K, farnesyl diphosphate
aristolochene synthase (PR-AS)variant R340K	Penicillium roqueforti	farnesyl diphosphate	8 × 10⁻⁴	0.00159	0.51		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant R340K, farnesyl diphosphate
aristolochene synthase (PR-AS)variant Y341F	Penicillium roqueforti	farnesyl diphosphate	0.0025	1.8 × 10⁻⁴	14		PMID 22349314	Open record: aristolochene synthase (PR-AS) variant Y341F, farnesyl diphosphate