EC 4.3.1.5: phenylalanine ammonia-lyase
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CatLog read 63 records for EC 4.3.1.5 from 7 papers, for 7 organisms. Names in these papers: phenylalanine ammonia-lyase (PAL), tyrosine ammonia-lyase (TAL), phenylalanine ammonia lyase (AvPAL), phenylalanine ammonia-lyase 1 (PAL1) and 10 more.
EC 4.3.1.5 is no longer current; BRENDA: “deleted. Now classified as EC 4.3.1.23”.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family | Arabidopsis thaliana, Rhodobacter sphaeroides | 14 |
| An active site homology model of phenylalanine ammonia-lyase from Petroselinum crispum | Petroselinum crispum | 12 |
| Phenylalanine ammonia-lyase: the use of its broad substrate specificity for mechanistic investigations and biocatalysis--synthesis of L-arylalanines | Petroselinum crispum | 11 |
| Cloning, expression, site-directed mutagenesis and immunolocalization of phenylalanine ammonia-lyase in Bambusa oldhamii | Bambusa oldhamii | 10 |
| The Arabidopsis phenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms | Arabidopsis thaliana | 7 |
| Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization | Anabaena variabilis, Nostoc punctiforme | 5 |
| Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity | Zea mays | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| AtPAL1 | Arabidopsis thaliana | L-phenylalanine | 1.8 | 0.068 | 25.5 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL1, L-phenylalanine |
| AtPAL1 | Arabidopsis thaliana | L-tyrosine | — | — | 0.075 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL1, L-tyrosine |
| AtPAL2 | Arabidopsis thaliana | L-phenylalanine | 3.2 | 0.064 | 51.2 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL2, L-phenylalanine |
| AtPAL2 | Arabidopsis thaliana | L-tyrosine | — | — | 0.04 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL2, L-tyrosine |
| AtPAL3 | Arabidopsis thaliana | L-phenylalanine | 0.1 | 2.56 | 0.05 | pH 8.8, 31 °C | PMID 15276452 | Open record: AtPAL3, L-phenylalanine |
| AtPAL4 | Arabidopsis thaliana | L-phenylalanine | 3 | 0.071 | 43.1 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL4, L-phenylalanine |
| AtPAL4 | Arabidopsis thaliana | L-tyrosine | — | — | 0.044 | pH 8.4, 37 °C | PMID 15276452 | Open record: AtPAL4, L-tyrosine |
| phenylalanine ammonia lyase (AvPAL) | Anabaena variabilis | L-phenylalanine | 4.3 | 0.06 | 72.2 | pH 8.5, 37 °C | PMID 17240984 | Open record: phenylalanine ammonia lyase (AvPAL), L-phenylalanine |
| phenylalanine ammonia lyase (AvPAL)variant L108A | Anabaena variabilis | L-phenylalanine | 3.6 | 0.069 | 52.5 | pH 8.5, 37 °C | PMID 17240984 | Open record: phenylalanine ammonia lyase (AvPAL) variant L108A, L-phenylalanine |
| phenylalanine ammonia lyase (AvPAL)variant L108G | Anabaena variabilis | L-phenylalanine | 0.95 | 0.07 | 14.6 | pH 8.5, 37 °C | PMID 17240984 | Open record: phenylalanine ammonia lyase (AvPAL) variant L108G, L-phenylalanine |
| phenylalanine ammonia lyase (AvPAL)variant ΔN21 (AvPALΔ21) | Anabaena variabilis | L-phenylalanine | 4.6 | 0.06 | 73.7 | pH 8.5, 37 °C | PMID 17240984 | Open record: phenylalanine ammonia lyase (AvPAL) variant ΔN21 (AvPALΔ21), L-phenylalanine |
| phenylalanine ammonia lyase (NpPAL) | Nostoc punctiforme | L-phenylalanine | 1.96 | 0.045 | 43.8 | pH 8.5, 37 °C | PMID 17240984 | Open record: phenylalanine ammonia lyase (NpPAL), L-phenylalanine |
| phenylalanine ammonia-lyase | Bambusa oldhamii | L-phenylalanine | — | 0.476 | — | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 2,3,4,5,6-pentafluoro-L-phenylalanine | — | 0.076 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 2,3,4,5,6-pentafluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 2,6-difluoro-L-phenylalanine | — | 0.085 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 2,6-difluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 2-chloro-L-phenylalanine | — | 0.05 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 2-chloro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 2-fluoro-L-phenylalanine | — | 0.065 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 2-fluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 3,5-difluoro-L-phenylalanine | — | 0.159 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 3,5-difluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 3-(pyrimidin-5-yl)-DL-alanine | — | 4.2 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 3-(pyrimidin-5-yl)-DL-alanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 3-chloro-L-phenylalanine | — | 0.094 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 3-chloro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 3-fluoro-L-phenylalanine | — | 0.079 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 3-fluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 4-chloro-L-phenylalanine | — | 0.045 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 4-chloro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | 4-fluoro-L-phenylalanine | — | 0.01 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), 4-fluoro-L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | L-phenylalanine | — | 0.033 | — | pH 8.8, 30 °C | PMID 11039531 | Open record: phenylalanine ammonia-lyase (PAL), L-phenylalanine |
| phenylalanine ammonia-lyase (PAL) | Petroselinum crispum | L-phenylalanine | 13.5 | 0.12 | 112.5 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL), L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant F400A | Petroselinum crispum | L-phenylalanine | 0.039 | 0.027 | 1.44 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant F400A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant L138H | Petroselinum crispum | L-phenylalanine | 0.99 | 13.5 | 0.073 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant L138H, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant L138H/Q488E | Petroselinum crispum | L-phenylalanine | 0.093 | 55 | 0.0017 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant L138H/Q488E, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant N260A | Petroselinum crispum | L-phenylalanine | 0.005 | 0.033 | 0.152 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant N260A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant Q348A | Petroselinum crispum | L-phenylalanine | 0.0057 | 0.03 | 0.19 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant Q348A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant Q488A | Petroselinum crispum | L-phenylalanine | 0.022 | 0.033 | 0.667 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant Q488A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant Q488E | Petroselinum crispum | L-phenylalanine | 2.1 | 0.057 | 36.8 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant Q488E, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant R354A | Petroselinum crispum | L-phenylalanine | 0.104 | 0.057 | 1.82 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant R354A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant S203A | Petroselinum crispum | L-phenylalanine | 0.031 | 0.019 | 1.63 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant S203A, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant Y110F | Petroselinum crispum | L-phenylalanine | 1.8 × 10⁻⁴ | — | — | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant Y110F, L-phenylalanine |
| phenylalanine ammonia-lyase (PAL)variant Y351F | Petroselinum crispum | L-phenylalanine | 0.057 | 0.024 | 2.38 | pH 8.8, 30 °C | PMID 12071972 | Open record: phenylalanine ammonia-lyase (PAL) variant Y351F, L-phenylalanine |
| phenylalanine ammonia-lyase 1 (PAL1) | Arabidopsis thaliana | L-phenylalanine | 115.8 | 0.0428 | 2.7 × 10³ | pH 9, 37 °C | PMID 17185227 | Open record: phenylalanine ammonia-lyase 1 (PAL1), L-phenylalanine |
| phenylalanine ammonia-lyase 1 (PAL1) | Arabidopsis thaliana | L-tyrosine | 0.084 | 1.049 | 0.08 | pH 9, 37 °C | PMID 17185227 | Open record: phenylalanine ammonia-lyase 1 (PAL1), L-tyrosine |
| phenylalanine ammonia-lyase 1 (PAL1)variant F144H | Arabidopsis thaliana | L-phenylalanine | 47.3 | 1.386 | 34 | pH 9, 37 °C | PMID 17185227 | Open record: phenylalanine ammonia-lyase 1 (PAL1) variant F144H, L-phenylalanine |
| phenylalanine ammonia-lyase 1 (PAL1)variant F144H | Arabidopsis thaliana | L-tyrosine | 0.75 | 0.5326 | 1.41 | pH 9, 37 °C | PMID 17185227 | Open record: phenylalanine ammonia-lyase 1 (PAL1) variant F144H, L-tyrosine |
| phenylalanine ammonia-lyase BoPAL1 | Bambusa oldhamii | L-phenylalanine | 16.29 | 0.23 | 70.8 | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL1, L-phenylalanine |
| phenylalanine ammonia-lyase BoPAL1variant F133H | Bambusa oldhamii | L-phenylalanine | 7.8 | 4.22 | 18.5 | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL1 variant F133H, L-phenylalanine |
| phenylalanine ammonia-lyase BoPAL1variant F133H | Bambusa oldhamii | L-tyrosine | 0.03 | 0.103 | 0.266 | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL1 variant F133H, L-tyrosine | |
| phenylalanine ammonia-lyase BoPAL2 | Bambusa oldhamii | L-phenylalanine | 21.3 | 0.333 | 63.9 | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL2, L-phenylalanine |
| phenylalanine ammonia-lyase BoPAL2 | Bambusa oldhamii | L-tyrosine | 0.03 | 0.993 | 0.0275 | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL2, L-tyrosine | |
| phenylalanine ammonia-lyase BoPAL2variant F134H | Bambusa oldhamii | L-phenylalanine | 19.2 | 2.288 | 8.39 | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL2 variant F134H, L-phenylalanine |
| phenylalanine ammonia-lyase BoPAL2variant F134H | Bambusa oldhamii | L-tyrosine | 0.1 | 0.335 | 0.309 | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL2 variant F134H, L-tyrosine | |
| phenylalanine ammonia-lyase BoPAL4 | Bambusa oldhamii | L-phenylalanine | 16.32 | 2.072 | 7.88 | pH 8.5, 37 °C | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL4, L-phenylalanine |
| phenylalanine ammonia-lyase BoPAL4 | Bambusa oldhamii | L-tyrosine | 0.54 | 0.097 | 5.56 | PMID 21035152 | Open record: phenylalanine ammonia-lyase BoPAL4, L-tyrosine | |
| phenylalanine ammonia-lyase ZmPAL1 | Zea mays | L-phenylalanine | 11.9 | 0.658 | 18.1 calc. | pH 7.7, 40 °C | PMID 9008393 | Open record: phenylalanine ammonia-lyase ZmPAL1, L-phenylalanine |
| phenylalanine ammonia-lyase ZmPAL1 | Zea mays | L-phenylalanine | 10.6 | 0.27 | 39 calc. | pH 8.7, 40 °C | PMID 9008393 | Open record: phenylalanine ammonia-lyase ZmPAL1, L-phenylalanine |
| phenylalanine ammonia-lyase ZmPAL1 | Zea mays | L-tyrosine | 0.94 | 0.041 | 23 calc. | pH 7.7, 40 °C | PMID 9008393 | Open record: phenylalanine ammonia-lyase ZmPAL1, L-tyrosine |
| phenylalanine ammonia-lyase ZmPAL1 | Zea mays | L-tyrosine | 0.92 | 0.019 | 48 calc. | pH 8.7, 40 °C | PMID 9008393 | Open record: phenylalanine ammonia-lyase ZmPAL1, L-tyrosine |
| tyrosine ammonia-lyase (TAL) | Rhodobacter sphaeroides | L-phenylalanine | 2.1 | 5.204 | 0.403 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL), L-phenylalanine |
| tyrosine ammonia-lyase (TAL) | Rhodobacter sphaeroides | L-tyrosine | 3.4 | 0.0314 | 110 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL), L-tyrosine |
| tyrosine ammonia-lyase (TAL)variant H89A | Rhodobacter sphaeroides | L-phenylalanine | 0.18 | 4.099 | 0.0439 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89A, L-phenylalanine |
| tyrosine ammonia-lyase (TAL)variant H89F | Rhodobacter sphaeroides | L-phenylalanine | 24 | 0.2691 | 89 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89F, L-phenylalanine |
| tyrosine ammonia-lyase (TAL)variant H89F | Rhodobacter sphaeroides | L-tyrosine | 0.0087 | 1.541 | 0.0056 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89F, L-tyrosine |
| tyrosine ammonia-lyase (TAL)variant H89N | Rhodobacter sphaeroides | L-phenylalanine | 1.03 | 3.456 | 0.298 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89N, L-phenylalanine |
| tyrosine ammonia-lyase (TAL)variant H89N | Rhodobacter sphaeroides | L-tyrosine | 0.03 | 1.399 | 0.0214 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89N, L-tyrosine |
| tyrosine ammonia-lyase (TAL)variant H89Q | Rhodobacter sphaeroides | L-phenylalanine | 26.2 | 0.7892 | 33 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89Q, L-phenylalanine |
| tyrosine ammonia-lyase (TAL)variant H89Q | Rhodobacter sphaeroides | L-tyrosine | 2.34 | 1.488 | 1.572 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89Q, L-tyrosine |
| tyrosine ammonia-lyase (TAL)variant H89W | Rhodobacter sphaeroides | L-phenylalanine | 0.19 | 3.777 | 0.0503 | pH 9, 37 °C | PMID 17185227 | Open record: tyrosine ammonia-lyase (TAL) variant H89W, L-phenylalanine |