EC 5.1.1.18: serine racemase
IsomerasesOpen in Browse
CatLog read 84 records for EC 5.1.1.18 from 5 papers, for 4 organisms. Names in these papers: serine racemase (SerR), serine racemase (hSR), serine racemase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 54 records for EC 5.1.1.18 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.1.1.18 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Triple serine loop region regulates the aspartate racemase activity of the serine/aspartate racemase family | Crassostrea gigas, Mus musculus and 1 more | 42 |
| Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP | Homo sapiens | 18 |
| Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity | Mus musculus | 16 |
| The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase | Homo sapiens | 5 |
| Human serine racemase is nitrosylated at multiple sites | Homo sapiens | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| serine racemase | Mus musculus | D-serineno ATP | 0.0033 | 8.5 | 3.5 × 10⁻⁴ | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, D-serine |
| serine racemase | Mus musculus | D-serine1 mM ATP | 0.042 | 9 | 0.0047 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, D-serine |
| serine racemase | Mus musculus | D-serineno ATP (as in Table I) | 0.0037 | 8 | 4.7 × 10⁻⁴ | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, D-serine |
| serine racemase | Mus musculus | D-serine1 mM ATP (as in Table I) | 0.028 | 8.2 | 0.0035 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, D-serine |
| serine racemase | Mus musculus | L-serineno ATP | 0.033 | 9 | 0.0037 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, L-serine |
| serine racemase | Mus musculus | L-serine1 mM ATP | 0.167 | 10 | 0.0167 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, L-serine |
| serine racemase | Mus musculus | L-serineracemization reaction; no ATP (as in Table I) | 0.02 | 9 | 0.0022 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, L-serine |
| serine racemase | Mus musculus | L-serineracemization reaction; 1 mM ATP (as in Table I) | 0.042 | 9 | 0.0045 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, L-serine |
| serine racemase | Mus musculus | L-threonine | 0.3 | 55 | 0.0055 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase, L-threonine |
| serine racemasevariant Q155D | Mus musculus | D-serine1 mM ATP | 0.0117 | 12 | 0.001 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, D-serine |
| serine racemasevariant Q155D | Mus musculus | D-serineno ATP (as in Table I) | 0.015 | 9.2 | 0.0017 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, D-serine |
| serine racemasevariant Q155D | Mus musculus | D-serine1 mM ATP (as in Table I) | 0.112 | 9.2 | 0.0122 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, D-serine |
| serine racemasevariant Q155D | Mus musculus | L-serine1 mM ATP | 0.033 | 11 | 0.003 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, L-serine |
| serine racemasevariant Q155D | Mus musculus | L-serineracemization reaction; no ATP (as in Table I) | 0.047 | 10 | 0.0047 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, L-serine |
| serine racemasevariant Q155D | Mus musculus | L-serineracemization reaction; 1 mM ATP (as in Table I) | 0.23 | 10.5 | 0.0222 | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, L-serine |
| serine racemasevariant Q155D | Mus musculus | L-threonine | 0.028 | 60 | 5 × 10⁻⁴ | pH 7.4, 37 °C | PMID 15536068 | Open record: serine racemase variant Q155D, L-threonine |
| serine racemase (hSR) | Homo sapiens | D-serineno ATP | 0.028 | 46 | 6 × 10⁻⁴ | pH 8 | PMID 29899358 | Open record: serine racemase (hSR), D-serine |
| serine racemase (hSR) | Homo sapiens | D-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.38 | 167 | 0.0024 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR), D-serine |
| serine racemase (hSR) | Homo sapiens | L-serine | 2.77 | 16 | 0.1702 | pH 8, 37 °C | PMID 29410194 | Open record: serine racemase (hSR), L-serine |
| serine racemase (hSR) | Homo sapiens | L-serineno ATP | 0.32 | 35 | 0.0092 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR), L-serine |
| serine racemase (hSR) | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.58 | 34 | 0.0175 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR), L-serine |
| serine racemase (hSR) | Homo sapiens | L-serineno ATP | 0.62 | 76 | 0.0081 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR), L-serine |
| serine racemase (hSR) | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 3.05 | 12 | 0.253 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR), L-serine |
| serine racemase (hSR)variant C113S | Homo sapiens | L-serine | 0.85 | 54 | 0.0158 | pH 8, 37 °C | PMID 29410194 | Open record: serine racemase (hSR) variant C113S, L-serine |
| serine racemase (hSR)variant C2S/C4S/C128S/C269S/C309S (Δ5Cys) | Homo sapiens | L-serine | 0.95 | 48 | 0.02 | pH 8, 37 °C | PMID 33249721 | Open record: serine racemase (hSR) variant C2S/C4S/C128S/C269S/C309S (Δ5Cys), L-serine |
| serine racemase (hSR)variant D318A | Homo sapiens | L-serine | 1.17 | 33 | 0.035 | pH 8, 37 °C | PMID 33249721 | Open record: serine racemase (hSR) variant D318A, L-serine |
| serine racemase (hSR)variant D318N | Homo sapiens | L-serine | 1.92 | 50 | 0.0383 | pH 8, 37 °C | PMID 29410194 | Open record: serine racemase (hSR) variant D318N, L-serine |
| serine racemase (hSR)variant E276Q | Homo sapiens | L-serine | 2.22 | 34 | 0.065 | pH 8, 37 °C | PMID 33249721 | Open record: serine racemase (hSR) variant E276Q, L-serine |
| serine racemase (hSR)variant K114Q | Homo sapiens | L-serine | 0.105 | 19 | 0.005 | pH 8, 37 °C | PMID 33249721 | Open record: serine racemase (hSR) variant K114Q, L-serine |
| serine racemase (hSR)variant N316A | Homo sapiens | L-serine | 0.127 | 41 | 0.0033 | pH 8, 37 °C | PMID 33249721 | Open record: serine racemase (hSR) variant N316A, L-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | D-serineno ATP | — | — | 0.0016 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, D-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | D-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | — | — | 0.0036 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, D-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | L-serineno ATP | 0.18 | 20 | 0.0094 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, L-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.23 | 16 | 0.0147 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, L-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | L-serineno ATP | 0.52 | 28 | 0.0181 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, L-serine |
| serine racemase (hSR)variant Q89A | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 1.63 | 27 | 0.0594 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89A, L-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | D-serineno ATP | 0.053 | 60 | 9 × 10⁻⁴ | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, D-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | D-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.16 | 65 | 0.0025 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, D-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | L-serineno ATP | 0.23 | 24 | 0.0099 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, L-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.4 | 22 | 0.018 | pH 8, 37 °C | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, L-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | L-serineno ATP | 0.28 | 22 | 0.0127 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, L-serine |
| serine racemase (hSR)variant Q89M | Homo sapiens | L-serinewith 2 mM ATP (allosteric activator; Mg2+ >= ATP) | 0.93 | 19 | 0.0489 | pH 8 | PMID 29899358 | Open record: serine racemase (hSR) variant Q89M, L-serine |
| serine racemase (SerR) | Crassostrea gigas | L-serine | 0.0291 | 2.26 | 0.014 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR), L-serine |
| serine racemase (SerR)variant P150S/P151S/Y152S | Crassostrea gigas | D-aspartic acid | 2.89 | 27.7 | 0.107 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P150S/P151S/Y152S, D-aspartic acid |
| serine racemase (SerR)variant P150S/P151S/Y152S | Crassostrea gigas | D-serine | 0.00423 | 12.7 | 3.38 × 10⁻⁴ | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P150S/P151S/Y152S, D-serine |
| serine racemase (SerR)variant P150S/P151S/Y152S | Crassostrea gigas | L-aspartic acid | 1.64 | 14.4 | 0.114 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P150S/P151S/Y152S, L-aspartic acid |
| serine racemase (SerR)variant P150S/P151S/Y152S | Crassostrea gigas | L-serine | 0.00488 | 15.1 | 3.24 × 10⁻⁴ | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P150S/P151S/Y152S, L-serine |
| serine racemase (SerR) | Mus musculus | D-serine | 0.0395 | 2.61 | 0.0152 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR), D-serine |
| serine racemase (SerR) | Mus musculus | L-serine | 0.285 | 4.79 | 0.0621 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR), L-serine |
| serine racemase (SerR)variant H150S | Mus musculus | D-serine | 0.516 | 37.4 | 0.0141 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S, D-serine |
| serine racemase (SerR)variant H150S | Mus musculus | L-serine | 0.605 | 46.4 | 0.0132 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S, L-serine |
| serine racemase (SerR)variant H150S/N152S | Mus musculus | D-aspartic acid | 0.0196 | 12.9 | 0.00152 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/N152S, D-aspartic acid |
| serine racemase (SerR)variant H150S/N152S | Mus musculus | D-serine | 0.611 | 55.2 | 0.0116 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/N152S, D-serine |
| serine racemase (SerR)variant H150S/N152S | Mus musculus | L-aspartic acid | 0.0368 | 24.9 | 0.00149 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/N152S, L-aspartic acid |
| serine racemase (SerR)variant H150S/N152S | Mus musculus | L-serine | 0.824 | 69.9 | 0.012 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/N152S, L-serine |
| serine racemase (SerR)variant H150S/P151S | Mus musculus | D-serine | 0.376 | 44.1 | 0.00858 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S, D-serine |
| serine racemase (SerR)variant H150S/P151S | Mus musculus | L-serine | 0.502 | 50.6 | 0.00992 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S, L-serine |
| serine racemase (SerR)variant H150S/P151S/N152S | Mus musculus | D-aspartic acid | 2.93 | 35 | 0.0836 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/N152S, D-aspartic acid |
| serine racemase (SerR)variant H150S/P151S/N152S | Mus musculus | D-serine | 0.816 | 172 | 0.00477 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/N152S, D-serine |
| serine racemase (SerR)variant H150S/P151S/N152S | Mus musculus | L-aspartic acid | 1.45 | 16.7 | 0.0862 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/N152S, L-aspartic acid |
| serine racemase (SerR)variant H150S/P151S/N152S | Mus musculus | L-serine | 0.277 | 53.4 | 0.00518 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/N152S, L-serine |
| serine racemase (SerR)variant N152S | Mus musculus | D-aspartic acid | 0.143 | 12.2 | 0.0117 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, D-aspartic acid |
| serine racemase (SerR)variant N152S | Mus musculus | D-serineracemase reaction (D-Ser to L-Ser) | 2.16 | 45.1 | 0.0478 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, D-serine |
| serine racemase (SerR)variant N152S | Mus musculus | D-serineserine dehydratase reaction (D-Ser to pyruvate) | 0.0427 | 1.96 | 0.0217 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, D-serine |
| serine racemase (SerR)variant N152S | Mus musculus | L-aspartic acid | 0.0779 | 8.27 | 0.00949 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, L-aspartic acid |
| serine racemase (SerR)variant N152S | Mus musculus | L-serineracemase reaction (L-Ser to D-Ser) | 0.872 | 18 | 0.0484 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, L-serine |
| serine racemase (SerR)variant N152S | Mus musculus | L-serineserine dehydratase reaction (L-Ser to pyruvate) | 0.128 | 6.31 | 0.0207 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant N152S, L-serine |
| serine racemase (SerR)variant P151S | Mus musculus | D-aspartic acid | 0.959 | 45.6 | 0.021 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, D-aspartic acid |
| serine racemase (SerR)variant P151S | Mus musculus | D-serineracemase reaction (D-Ser to L-Ser) | 5.68 | 28.9 | 0.195 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, D-serine |
| serine racemase (SerR)variant P151S | Mus musculus | D-serineserine dehydratase reaction (D-Ser to pyruvate) | 0.203 | 1.95 | 0.112 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, D-serine |
| serine racemase (SerR)variant P151S | Mus musculus | L-aspartic acid | 0.406 | 23.3 | 0.0176 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, L-aspartic acid |
| serine racemase (SerR)variant P151S | Mus musculus | L-serineracemase reaction (L-Ser to D-Ser) | 5.71 | 30 | 0.191 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, L-serine |
| serine racemase (SerR)variant P151S | Mus musculus | L-serineserine dehydratase reaction (L-Ser to pyruvate) | 0.244 | 2.61 | 0.0967 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S, L-serine |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | D-aspartic acid | 3.88 | 10.4 | 0.373 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, D-aspartic acid |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | D-serineracemase reaction (D-Ser to L-Ser) | 3.74 | 69.7 | 0.0537 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, D-serine |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | D-serineserine dehydratase reaction (D-Ser to pyruvate) | 0.596 | 0.518 | 1.09 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, D-serine |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | L-aspartic acid | 2.01 | 5.83 | 0.343 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, L-aspartic acid |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | L-serineracemase reaction (L-Ser to D-Ser) | 1.88 | 38.1 | 0.0495 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, L-serine |
| serine racemase (SerR)variant P151S/N152S | Mus musculus | L-serineserine dehydratase reaction (L-Ser to pyruvate) | 0.523 | 0.836 | 0.635 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant P151S/N152S, L-serine |
| serine racemase (SerR) | Penaeus monodon | L-serine | 0.0489 | 47.4 | 0.001036 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR), L-serine |
| serine racemase (SerR)variant H150S/P151S/F152S | Penaeus monodon | D-aspartic acid | 1.12 | 160 | 0.00699 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/F152S, D-aspartic acid |
| serine racemase (SerR)variant H150S/P151S/F152S | Penaeus monodon | D-serine | 0.057 | 252 | 2.26 × 10⁻⁴ | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/F152S, D-serine |
| serine racemase (SerR)variant H150S/P151S/F152S | Penaeus monodon | L-aspartic acid | 0.372 | 48.6 | 0.00761 | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/F152S, L-aspartic acid |
| serine racemase (SerR)variant H150S/P151S/F152S | Penaeus monodon | L-serine | 0.0335 | 125 | 2.68 × 10⁻⁴ | pH 8, 30 °C | PMID 28744579 | Open record: serine racemase (SerR) variant H150S/P151S/F152S, L-serine |