EC 5.3.99.2: Prostaglandin-D synthase
IsomerasesOpen in Browse
CatLog read 49 records for EC 5.3.99.2 from 3 papers, for 3 organisms. Names in these papers: hematopoietic prostaglandin D synthase, lipocalin type prostaglandin D synthase (L-PGDS), lipocalin-type prostaglandin D synthase (L-PGDS).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 20 records for EC 5.3.99.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.3.99.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis | Rattus norvegicus | 24 |
| Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase | Mus musculus | 13 |
| Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules | Homo sapiens | 12 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| hematopoietic prostaglandin D synthase | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 5 | 3 | 1.7 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthase | Rattus norvegicus | glutathione | 31.07 | 0.1 | 310 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase, glutathione |
| hematopoietic prostaglandin D synthase | Rattus norvegicus | glutathione | 2 | 0.5 | 4.0 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase, glutathione |
| hematopoietic prostaglandin D synthase | Rattus norvegicus | prostaglandin H2 | 21.7 | 0.5 | 43 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase, prostaglandin H2 |
| hematopoietic prostaglandin D synthasevariant C156L | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 0.7 | 0.6 | 1.2 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant C156L, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant C156L | Rattus norvegicus | glutathione | 0.55 | 1.11 | 0.50 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant C156L, glutathione |
| hematopoietic prostaglandin D synthasevariant C156Y | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 0.8 | 4.87 | 0.16 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant C156Y, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant C156Y | Rattus norvegicus | glutathione | 0.3 | 0.5 | 0.60 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant C156Y, glutathione |
| hematopoietic prostaglandin D synthasevariant K112E | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 0.6 | 3.66 | 0.16 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K112E, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant K112E | Rattus norvegicus | glutathione | 3.42 | 0.18 | 19 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K112E, glutathione |
| hematopoietic prostaglandin D synthasevariant K112E | Rattus norvegicus | glutathione | 1.92 | 2.23 | 0.861 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K112E, glutathione |
| hematopoietic prostaglandin D synthasevariant K112E | Rattus norvegicus | prostaglandin H2 | 4.3 | 0.49 | 8.8 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K112E, prostaglandin H2 |
| hematopoietic prostaglandin D synthasevariant K198E | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 4.6 | 2.4 | 1.9 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K198E, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant K198E | Rattus norvegicus | glutathione | 8.4 | 0.05 | 170 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K198E, glutathione |
| hematopoietic prostaglandin D synthasevariant K198E | Rattus norvegicus | glutathione | 2.16 | 0.7 | 3.1 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K198E, glutathione |
| hematopoietic prostaglandin D synthasevariant K198E | Rattus norvegicus | prostaglandin H2 | 7.18 | 0.7 | 10 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant K198E, prostaglandin H2 |
| hematopoietic prostaglandin D synthasevariant L199F | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 1.4 | 2.15 | 0.65 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant L199F, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant L199F | Rattus norvegicus | glutathione | 29.6 | 0.09 | 330 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant L199F, glutathione |
| hematopoietic prostaglandin D synthasevariant L199F | Rattus norvegicus | glutathione | 1.5 | 0.7 | 2.1 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant L199F, glutathione |
| hematopoietic prostaglandin D synthasevariant L199F | Rattus norvegicus | prostaglandin H2 | 20.3 | 1.01 | 20.1 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant L199F, prostaglandin H2 |
| hematopoietic prostaglandin D synthasevariant Y152F | Rattus norvegicus | 1-chloro-2,4-dinitrobenzene | 1.5 | 2 | 0.75 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant Y152F, 1-chloro-2,4-dinitrobenzene |
| hematopoietic prostaglandin D synthasevariant Y152F | Rattus norvegicus | glutathione | 29.5 | 0.08 | 370 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant Y152F, glutathione |
| hematopoietic prostaglandin D synthasevariant Y152F | Rattus norvegicus | glutathione | 1.76 | 0.8 | 2.2 calc. | pH 6.5 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant Y152F, glutathione |
| hematopoietic prostaglandin D synthasevariant Y152F | Rattus norvegicus | prostaglandin H2 | 15.55 | 0.55 | 28 calc. | pH 8 | PMID 10871602 | Open record: hematopoietic prostaglandin D synthase variant Y152F, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS) | Mus musculus | prostaglandin H2 | — | 8 × 10⁻⁴ | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS), prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant H111A | Mus musculus | prostaglandin H2 | — | 0.0014 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant H111A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant H116A | Mus musculus | prostaglandin H2 | — | 0.0014 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant H116A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant P110A | Mus musculus | prostaglandin H2 | — | 0.0016 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant P110A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant S45A | Mus musculus | prostaglandin H2 | — | 5 × 10⁻⁴ | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant S45A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant S45A/S81A | Mus musculus | prostaglandin H2 | — | 0.0012 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant S45A/S81A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant S45A/T67A | Mus musculus | prostaglandin H2 | — | 0.0021 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant S45A/T67A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant S45A/T67A/S81A | Mus musculus | prostaglandin H2 | — | 0.0012 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant S45A/T67A/S81A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant S81A | Mus musculus | prostaglandin H2 | — | 0.0015 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant S81A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant T67A | Mus musculus | prostaglandin H2 | — | 0.0028 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant T67A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant T67A/S81A | Mus musculus | prostaglandin H2 | — | 0.0021 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant T67A/S81A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant W54A | Mus musculus | prostaglandin H2 | — | 0.0013 | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant W54A, prostaglandin H2 |
| lipocalin type prostaglandin D synthase (L-PGDS)variant W54A/H111A | Mus musculus | prostaglandin H2 | — | 8 × 10⁻⁴ | — | pH 8, 25 °C | PMID 19546224 | Open record: lipocalin type prostaglandin D synthase (L-PGDS) variant W54A/H111A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS) | Homo sapiens | prostaglandin H2 | 2.64 | 0.0138 | 191.5 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS), prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant F83A | Homo sapiens | prostaglandin H2 | 0.87 | 0.0245 | 35.3 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant F83A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant K59A | Homo sapiens | prostaglandin H2 | 5.84 | 0.0123 | 414 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant K59A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant L131A | Homo sapiens | prostaglandin H2 | 0.81 | 0.0252 | 31.5 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant L131A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant L79A | Homo sapiens | prostaglandin H2 | 0.06 | 0.0328 | 1.8 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant L79A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant M64A | Homo sapiens | prostaglandin H2 | 0.63 | 0.0325 | 19.5 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant M64A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant M94A | Homo sapiens | prostaglandin H2 | 2.24 | 0.0202 | 111 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant M94A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant S45A | Homo sapiens | prostaglandin H2 | 2.23 | 0.0204 | 109.5 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant S45A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant S81A | Homo sapiens | prostaglandin H2 | 2.91 | 0.0185 | 157 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant S81A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant T147A | Homo sapiens | prostaglandin H2 | 3.67 | 0.0154 | 238.2 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant T147A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant W54A | Homo sapiens | prostaglandin H2 | 2.4 | 0.0161 | 149 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant W54A, prostaglandin H2 |
| lipocalin-type prostaglandin D synthase (L-PGDS)variant Y149A | Homo sapiens | prostaglandin H2 | 5.73 | 0.0127 | 450.8 | pH 8, 25 °C | PMID 20667974 | Open record: lipocalin-type prostaglandin D synthase (L-PGDS) variant Y149A, prostaglandin H2 |