CatLogenzyme kinetics catalog

EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase

LigasesOpen in Browse

CatLog read 7 records for EC 6.2.1.43 from 1 paper, for 1 organism. Names in these papers: NcsB2 (naphthoic acid/CoA ligase).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

Papers

PaperOrganismsRecords
Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatinStreptomyces carzinostaticus7

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus1-naphthoic acid0.1120.0186.2 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2,7-dihydroxy-5-methyl-1-naphthoic acid1.550.0031500 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2-hydroxy-1-naphthoic acid0.0470.003414 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2-hydroxy-5,7-dimethoxy-1-naphthoic acid0.420.0011380 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2-hydroxy-5-methyl-1-naphthoic acid0.1352.5 × 10⁻⁴540 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2-hydroxy-7-methoxy-1-naphthoic acid0.1180.002351 calc.PMID 17539640Open
NcsB2 (naphthoic acid/CoA ligase)Streptomyces carzinostaticus2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid0.635.9 × 10⁻⁴1.1 × 10³ calc.PMID 17539640Open