CatLogenzyme kinetics catalog

EC 7.6.2.3: ABC-type glutathione-S-conjugate transporter

TranslocasesOpen in Browse

CatLog read 12 records for EC 7.6.2.3 from 4 papers, for 3 organisms. Names in these papers: multidrug resistance-associated protein 3 (Mrp3), Ycf1p (vacuolar ABC transporter, ABCC subfamily), MRP4 (ABCC4), multidrug resistance protein 4, multidrug resistance-associated protein (MRP).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 48 records for EC 7.6.2.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 7.6.2.3 in Browse.

Papers

PaperOrganismsRecords
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicus4
Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extensionSaccharomyces cerevisiae4
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugsHomo sapiens2
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugatesHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
MRP4 (ABCC4), multidrug resistance protein 4Homo sapiensprostaglandin E1—0.0021—37 °CPMID 12835412Open
MRP4 (ABCC4), multidrug resistance protein 4Homo sapiensprostaglandin E2—0.0034—37 °CPMID 12835412Open
multidrug resistance-associated protein (MRP)Homo sapiensadenosine 5'-triphosphate—0.019—pH 7.4PMID 7961706Open
multidrug resistance-associated protein (MRP)Homo sapiensleukotriene C4—9.7 × 10⁻⁵—pH 7.4PMID 7961706Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicusadenosine 5'-triphosphateuptake of 55 nM [3H]E217βG—1.36—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicusadenosine 5'-triphosphateuptake of 1.2 µM [3H]TC—0.66—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicustaurocholate—0.0159—pH 7.4, 37 °CPMID 10644759Open
multidrug resistance-associated protein 3 (Mrp3)Rattus norvegicustaurolithocholate-3-sulfate—0.00306—pH 7.4, 37 °CPMID 10644759Open
Ycf1p (vacuolar ABC transporter, ABCC subfamily)Saccharomyces cerevisiaeestradiol-17beta-glucuronide—0.394—pH 8, 25 °CPMID 18667437Open
Ycf1p (vacuolar ABC transporter, ABCC subfamily)variant S251ASaccharomyces cerevisiaeestradiol-17beta-glucuronide—0.187—pH 8, 25 °CPMID 18667437Open
Ycf1p (vacuolar ABC transporter, ABCC subfamily)variant S251ESaccharomyces cerevisiaeestradiol-17beta-glucuronide—0.481—pH 8, 25 °CPMID 18667437Open
Ycf1p (vacuolar ABC transporter, ABCC subfamily)variant S908A/T911ASaccharomyces cerevisiaeestradiol-17beta-glucuronide—0.548—pH 8, 25 °CPMID 18667437Open