CatLogenzyme kinetics catalog

Values CatLog read from this paper

Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X

PMID 11343794doi:10.1016/s0167-4838(01)00171-6Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 48 records (144 values) from this paper: cathepsin B, cathepsin L, papain from Homo sapiens, Carica papaya.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.4.22.1, EC 3.4.22.2

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
cathepsin BHomo sapiensN-acetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin210.452.5pH 6, 37 °COpen
cathepsin BHomo sapiensN-acetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin3.30.05659pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-3-(3-pyridyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin29.40.0396742pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-3-(4-aminocyclohexyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin (cis/trans mixture)17.20.01531124pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-3-(piperidin-4-yl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin31.30.052602pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-3-[trans-4-(aminomethyl)cyclohexyl]-L-alanyl-L-arginine 7-amido-4-methylcoumarin390.02541535pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-4-(aminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin320.01961633pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-4-(isopropylaminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin300.0325923pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-4-guanidino-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin360.0231572pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin180.0325554pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-L-histidyl-L-arginine 7-amido-4-methylcoumarin380.03421111pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzoyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin700.032315pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzyloxycarbonyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin180.082220pH 6, 37 °COpen
cathepsin BHomo sapiensN-benzyloxycarbonyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin75.90.02343.26 × 10³pH 6, 37 °COpen
cathepsin BHomo sapiensN-phenylacetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin170.0814210pH 6, 37 °COpen
cathepsin BHomo sapiensN-phenylacetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin710.02742591pH 6, 37 °COpen
cathepsin LHomo sapiensN-acetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin10.1248.1pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-acetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin180.0181 × 10³pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-3-(3-pyridyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin5.40.0066818pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-3-(4-aminocyclohexyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin (cis/trans mixture)0.580.029620pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-3-(piperidin-4-yl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin0.750.10337.3pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-3-[trans-4-(aminomethyl)cyclohexyl]-L-alanyl-L-arginine 7-amido-4-methylcoumarin4.40.011400pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-4-(aminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin5.70.0093613pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-4-(isopropylaminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin9.40.0127739pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-4-guanidino-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin9.20.021438pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin1.60.043636.7pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-L-histidyl-L-arginine 7-amido-4-methylcoumarin2.80.08732pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzoyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin10.40.00119455pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzyloxycarbonyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin0.220.0514.3pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-benzyloxycarbonyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin10.30.0025.15 × 10³pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-phenylacetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin2.250.07330.8pH 5.5, 37 °COpen
cathepsin LHomo sapiensN-phenylacetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin200.00141.388 × 10⁴pH 5.5, 37 °COpen
papainCarica papayaN-acetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin2.70.18715pH 6.8, 37 °COpen
papainCarica papayaN-acetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin640.01943299pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-3-(3-pyridyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin49.20.01343672pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-3-(4-aminocyclohexyl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin (cis/trans mixture)1.40.044532pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-3-(piperidin-4-yl)-L-alanyl-L-arginine 7-amido-4-methylcoumarin1.90.112317pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-3-[trans-4-(aminomethyl)cyclohexyl]-L-alanyl-L-arginine 7-amido-4-methylcoumarin6.90.0323214pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-4-(aminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin31.60.057554pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-4-(isopropylaminomethyl)-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin12.40.022564pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-4-guanidino-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin28.60.049583pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin0.60.04912pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-L-histidyl-L-arginine 7-amido-4-methylcoumarin6.80.052131pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin56.60.01443931pH 6.8, 37 °COpen
papainCarica papayaN-benzoyl-N(im)-dimethyl-histidyl-L-arginine 7-amido-4-methylcoumarin0.60.1135pH 6.8, 37 °COpen
papainCarica papayaN-benzyloxycarbonyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin23.20.012.32 × 10³pH 6.8, 37 °COpen
papainCarica papayaN-phenylacetyl-L-arginyl-L-arginine 7-amido-4-methylcoumarin180.12714pH 6.8, 37 °COpen
papainCarica papayaN-phenylacetyl-L-phenylalanyl-L-arginine 7-amido-4-methylcoumarin77.80.0145557pH 6.8, 37 °COpen