Values CatLog read from this paper
Investigation of conserved acidic residues in 3-hydroxy-3-methylglutaryl-CoA lyase: implications for human disease and for functional roles in a family of related proteins
PMID 12874287doi:10.1074/jbc.m304472200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 8 records (24 values) from this paper: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 108 | 0.048 | 2.27 × 10³ | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase), (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant D204A | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 5.5 | 0.166 | 33 | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant D204A, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant D280A | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 110.5 | 0.017 | 6.39 × 10³ | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant D280A, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant D42E | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 11.3 | 0.032 | 350 | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant D42E, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant D42N | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 0.187 | 0.043 | 4.4 | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant D42N, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant E279A | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 92.4 | 0.027 | 3.38 × 10³ | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant E279A, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant E37D | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 86.2 | 0.036 | 2.39 × 10³ | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant E37D, (S)-3-hydroxy-3-methylglutaryl-CoA | |
| 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase)variant E72A | Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA | 0.57 | 0.477 | 1.2 | Open record: 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) variant E72A, (S)-3-hydroxy-3-methylglutaryl-CoA |