Values CatLog read from this paper
Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site
PMID 12902323doi:10.1074/jbc.m306204200Open in Browse
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CatLog read 6 records (18 values) from this paper: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) | Homo sapiens | thiamin diphosphate | 6.38 | 5.5 × 10⁻⁴ | 1.16 × 10⁴ | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer), thiamin diphosphate | |
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) | Homo sapiens | α-ketoisovalerate | 8.65 | 0.059 | 146 | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer), α-ketoisovalerate | |
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer)variant H291N | Homo sapiens | thiamin diphosphate | 0.6 | 0.0014 | 420 | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) variant H291N, thiamin diphosphate | |
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer)variant H291N | Homo sapiens | α-ketoisovalerate | 0.67 | 0.118 | 5.6 | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) variant H291N, α-ketoisovalerate | |
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer)variant H291Q | Homo sapiens | thiamin diphosphate | 0.41 | 0.009 | 45 | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) variant H291Q, thiamin diphosphate | |
| branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer)variant H291Q | Homo sapiens | α-ketoisovalerate | 0.49 | 0.203 | 2.4 | Open record: branched-chain α-ketoacid dehydrogenase E1b (α2β2 heterotetramer) variant H291Q, α-ketoisovalerate |