Values CatLog read from this paper

Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and…

PMID 15100172doi:10.1124/dmd.32.5.505Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 7 records (21 values) from this paper: CES2, CES1A1, CES3 from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.1.1.1

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
CES1A1	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin	3 × 10⁻⁵	0.08	3.8 × 10⁻⁴	pH 7, 37 °C	Open record: CES1A1, 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin
CES1A1	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)	8.2 × 10⁻⁵	0.039	0.0022	pH 7, 37 °C	Open record: CES1A1, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)
CES2	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin	2.7 × 10⁻⁴	0.0032	0.083	pH 7, 37 °C	Open record: CES2, 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin
CES2	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)	2.2 × 10⁻⁴	0.0011	0.2	pH 7, 37 °C	Open record: CES2, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)
CES2	Homo sapiens	7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin	4.08 × 10⁻⁵	0.27	2.5 × 10⁻⁴	pH 7, 37 °C	Open record: CES2, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin
CES3	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin	4.3 × 10⁻⁶	0.46	9.3 × 10⁻⁶	pH 7, 37 °C	Open record: CES3, 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin
CES3	Homo sapiens	7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)	1.5 × 10⁻⁵	0.137	1.05 × 10⁻⁴	pH 7, 37 °C	Open record: CES3, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (irinotecan)