Values CatLog read from this paper
Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6
PMID 15665333doi:10.1074/jbc.m411019200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 14 records (28 values) from this paper: cytochrome P450 2A6 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 14 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| cytochrome P450 2A6 | Homo sapiens | 7-ethoxycoumarinWITHOUT cytochrome b5 | 0.045 | 0.039 | 1.2 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-ethoxycoumarinWITHOUT cytochrome b5 | 0.133 | 0.12 | 1.1 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-ethoxycoumarinWITH recombinant human cytochrome b5 | 0.033 | 0.01 | 3.3 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-ethoxycoumarinWITH recombinant human cytochrome b5 | 0.167 | 0.015 | 11 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-methoxycoumarinWITHOUT cytochrome b5 | 0.04 | 0.013 | 3.1 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-methoxycoumarinWITHOUT cytochrome b5 | 0.016 | 0.012 | 1.3 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-methoxycoumarinWITH recombinant human cytochrome b5 | 0.037 | 0.01 | 3.7 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | 7-methoxycoumarinWITH recombinant human cytochrome b5 | 0.018 | 0.011 | 1.6 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, 7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | [1-ethyl-d2]-7-ethoxycoumarinO-dealkylation (7-OH coumarin formation) | 0.0057 | 0.035 | 0.16 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, [1-ethyl-d2]-7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | [1-ethyl-d2]-7-ethoxycoumarin3-hydroxylation (3-OH product formation) | 0.158 | 0.124 | 1.30 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, [1-ethyl-d2]-7-ethoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | [methyl-d3]-7-methoxycoumarinO-dealkylation (7-OH coumarin formation) | 0.0042 | 0.013 | 0.32 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, [methyl-d3]-7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | [methyl-d3]-7-methoxycoumarin3-hydroxylation (3-OH product formation) | 0.032 | 0.011 | 2.9 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, [methyl-d3]-7-methoxycoumarin |
| cytochrome P450 2A6 | Homo sapiens | coumarinWITHOUT cytochrome b5 | 0.075 | 0.0018 | 42 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, coumarin |
| cytochrome P450 2A6 | Homo sapiens | coumarinWITH recombinant human cytochrome b5 | 0.148 | 0.0014 | 110 calc. | pH 7.4, 37 °C | Open record: cytochrome P450 2A6, coumarin |