Values CatLog read from this paper

Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis

PMID 16215230doi:10.1074/jbc.m508182200Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 51 records (153 values) from this paper: cytochrome P450 2A6 from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
cytochrome P450 2A6	Homo sapiens	2H-chromen-2-one	0.12	0.0044	27	pH 7.4, 37 °C	Open record: cytochrome P450 2A6, 2H-chromen-2-one
cytochrome P450 2A6	Homo sapiens	4-chloroindole	0.02	0.055	0.37	pH 7.4, 37 °C	Open record: cytochrome P450 2A6, 4-chloroindole
cytochrome P450 2A6	Homo sapiens	indole	0.028	0.157	0.18	pH 7.4, 37 °C	Open record: cytochrome P450 2A6, indole
cytochrome P450 2A6variant I300V	Homo sapiens	4-chloroindole	0.032	0.174	0.18	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant I300V, 4-chloroindole
cytochrome P450 2A6variant I300V	Homo sapiens	indole	0.032	0.145	0.22	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant I300V, indole
cytochrome P450 2A6variant L240C/N297Q	Homo sapiens	2H-chromen-2-one	0.75	0.019	40	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q, 2H-chromen-2-one
cytochrome P450 2A6variant L240C/N297Q	Homo sapiens	4-chloroindole	0.25	0.215	1.17	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q, 4-chloroindole
cytochrome P450 2A6variant L240C/N297Q	Homo sapiens	indole	0.45	0.222	2	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q, indole
cytochrome P450 2A6variant L240C/N297Q/I300V	Homo sapiens	4-(benzyloxy)-1H-indole	0.08	0.486	0.165	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant L240C/N297Q/I300V	Homo sapiens	4-chloroindole	0.72	1.62	0.45	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V, 4-chloroindole
cytochrome P450 2A6variant L240C/N297Q/I300V	Homo sapiens	5-(benzyloxy)-1H-indole	0.05	0.418	0.12	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant L240C/N297Q/I300V	Homo sapiens	indole	0.198	0.062	3.2	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V, indole
cytochrome P450 2A6variant L240C/N297Q/I300V/I366V	Homo sapiens	4-(benzyloxy)-1H-indole	0.008	0.042	0.18	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V/I366V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant L240C/N297Q/I300V/I366V	Homo sapiens	4-chloroindole	0.117	0.083	1.4	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V/I366V, 4-chloroindole
cytochrome P450 2A6variant L240C/N297Q/I300V/I366V	Homo sapiens	5-(benzyloxy)-1H-indole	0.0063	0.043	0.147	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V/I366V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant L240C/N297Q/I300V/I366V	Homo sapiens	indole	0.155	0.149	1.03	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I300V/I366V, indole
cytochrome P450 2A6variant L240C/N297Q/I366V	Homo sapiens	4-chloroindole	0.23	0.304	0.77	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I366V, 4-chloroindole
cytochrome P450 2A6variant L240C/N297Q/I366V	Homo sapiens	indole	0.112	0.129	0.87	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant L240C/N297Q/I366V, indole
cytochrome P450 2A6variant N297Q	Homo sapiens	4-chloroindole	0.138	0.26	0.53	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q, 4-chloroindole
cytochrome P450 2A6variant N297Q	Homo sapiens	indole	0.22	0.28	0.77	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q, indole
cytochrome P450 2A6variant N297Q/I300V	Homo sapiens	2H-chromen-2-one	0.57	0.018	32	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V, 2H-chromen-2-one
cytochrome P450 2A6variant N297Q/I300V	Homo sapiens	4-(benzyloxy)-1H-indole	0.063	0.449	0.142	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant N297Q/I300V	Homo sapiens	4-chloroindole	0.23	0.652	0.35	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V, 4-chloroindole
cytochrome P450 2A6variant N297Q/I300V	Homo sapiens	5-(benzyloxy)-1H-indole	0.028	0.201	0.142	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant N297Q/I300V	Homo sapiens	indole	0.3	0.196	1.53	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V, indole
cytochrome P450 2A6variant N297Q/I300V/I366V	Homo sapiens	4-(benzyloxy)-1H-indole	0.02	0.122	0.163	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V/I366V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant N297Q/I300V/I366V	Homo sapiens	4-chloroindole	0.9	3.039	0.3	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V/I366V, 4-chloroindole
cytochrome P450 2A6variant N297Q/I300V/I366V	Homo sapiens	5-(benzyloxy)-1H-indole	0.028	0.285	0.1	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V/I366V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant N297Q/I300V/I366V	Homo sapiens	indole	0.145	0.164	0.88	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant N297Q/I300V/I366V, indole
cytochrome P450 2A6variant V140M/L240C/I300V/I366V	Homo sapiens	4-chloroindole	0.105	0.276	0.38	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/I300V/I366V, 4-chloroindole
cytochrome P450 2A6variant V140M/L240C/I300V/I366V	Homo sapiens	indole	0.047	0.075	0.62	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/I300V/I366V, indole
cytochrome P450 2A6variant V140M/L240C/N297Q	Homo sapiens	4-chloroindole	0.133	0.126	1.05	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q, 4-chloroindole
cytochrome P450 2A6variant V140M/L240C/N297Q	Homo sapiens	indole	0.107	0.071	1.5	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q, indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V	Homo sapiens	4-(benzyloxy)-1H-indole	0.025	0.139	0.18	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V	Homo sapiens	4-chloroindole	0.057	0.074	0.77	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V, 4-chloroindole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V	Homo sapiens	5-(benzyloxy)-1H-indole	0.01	0.054	0.18	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V	Homo sapiens	indole	0.147	0.096	1.53	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V, indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V/I366V	Homo sapiens	4-(benzyloxy)-1H-indole	0.0075	0.047	0.16	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V/I366V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V/I366V	Homo sapiens	4-chloroindole	0.23	0.186	1.25	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V/I366V, 4-chloroindole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V/I366V	Homo sapiens	5-(benzyloxy)-1H-indole	0.0047	0.051	0.092	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V/I366V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I300V/I366V	Homo sapiens	indole	0.2	0.152	1.32	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I300V/I366V, indole
cytochrome P450 2A6variant V140M/L240C/N297Q/I366V	Homo sapiens	4-chloroindole	0.85	1.212	0.7	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I366V, 4-chloroindole
cytochrome P450 2A6variant V140M/L240C/N297Q/I366V	Homo sapiens	indole	2.18	1.769	1.23	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/L240C/N297Q/I366V, indole
cytochrome P450 2A6variant V140M/N297Q/I300V	Homo sapiens	4-(benzyloxy)-1H-indole	0.088	0.864	0.102	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/N297Q/I300V	Homo sapiens	4-chloroindole	0.148	0.383	0.38	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V, 4-chloroindole
cytochrome P450 2A6variant V140M/N297Q/I300V	Homo sapiens	5-(benzyloxy)-1H-indole	0.027	0.288	0.093	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/N297Q/I300V	Homo sapiens	indole	0.108	0.056	2	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V, indole
cytochrome P450 2A6variant V140M/N297Q/I300V/I366V	Homo sapiens	4-(benzyloxy)-1H-indole	0.0152	0.108	0.14	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V/I366V, 4-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/N297Q/I300V/I366V	Homo sapiens	4-chloroindole	0.06	0.087	0.68	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V/I366V, 4-chloroindole
cytochrome P450 2A6variant V140M/N297Q/I300V/I366V	Homo sapiens	5-(benzyloxy)-1H-indole	0.0083	0.055	0.152	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V/I366V, 5-(benzyloxy)-1H-indole
cytochrome P450 2A6variant V140M/N297Q/I300V/I366V	Homo sapiens	indole	0.087	0.159	0.55	pH 7.4, 37 °C	Open record: cytochrome P450 2A6 variant V140M/N297Q/I300V/I366V, indole