Values CatLog read from this paper
Nucleoside ester prodrug substrate specificity of liver carboxylesterase
PMID 16223870doi:10.1124/jpet.105.092726Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 38 records (114 values) from this paper: liver carboxylesterase 1 (pCES1) from Sus scrofa (porcine).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-D-Phenylalanyl-gemcitabine | 8.732 | 0.97 | 9.022 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-D-Phenylalanyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-D-Valyl-gemcitabine | 0.112 | 1.43 | 0.078 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-D-Valyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-L-Isoleucyl-gemcitabine | 0.083 | 0.94 | 0.088 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-L-Isoleucyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-L-Phenylalanyl-gemcitabine | 6.083 | 0.51 | 11.97 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-L-Phenylalanyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-L-Valyl-gemcitabine | 0.122 | 0.9 | 0.135 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-L-Valyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(D-phenylalanyl)-5-fluoro-2'-deoxyuridine | 1.392 | 1.4 | 0.992 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(D-phenylalanyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(D-valyl)-5-fluoro-2'-deoxyuridine | 0.093 | 11.23 | 0.0083 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(D-valyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-aspartyl)-5-fluoro-2'-deoxyuridine | 0.035 | 0.93 | 0.038 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-aspartyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-isoleucyl)-5-fluoro-2'-deoxyuridine | 0.055 | 1.11 | 0.05 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-isoleucyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-leucyl)-5-fluoro-2'-deoxyuridine | 0.242 | 1.46 | 0.165 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-leucyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-lysyl)-5-fluoro-2'-deoxyuridine | 0.203 | 3.08 | 0.067 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-lysyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-phenylalanyl)-5-fluoro-2'-deoxyuridine | 0.533 | 0.74 | 0.715 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-phenylalanyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-prolyl)-5-fluoro-2'-deoxyuridine | 1.555 | 4.85 | 0.32 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-prolyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 3'-O-(L-valyl)-5-fluoro-2'-deoxyuridine | 0.065 | 2.87 | 0.022 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 3'-O-(L-valyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-D-Phenylalanyl-gemcitabine | 1.095 | 0.22 | 5.027 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-D-Phenylalanyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-D-Valyl-gemcitabine | 0.0083 | 1.16 | 0.0083 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-D-Valyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-L-Isoleucyl-gemcitabine | 0.033 | 0.85 | 0.038 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-L-Isoleucyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-L-Phenylalanyl-gemcitabine | 1.117 | 0.17 | 6.445 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-L-Phenylalanyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-L-Valyl-gemcitabine | 0.0083 | 0.96 | 0.0083 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-L-Valyl-gemcitabine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(D-phenylalanyl)-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole | 0.55 | 0.9 | 0.608 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(D-phenylalanyl)-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(D-phenylalanyl)-5-fluoro-2'-deoxyuridine | 0.56 | 0.44 | 1.287 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(D-phenylalanyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(D-valyl)-5-fluoro-2'-deoxyuridine | 0.102 | 4.12 | 0.025 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(D-valyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-aspartyl)-5-fluoro-2'-deoxyuridine | 0.115 | 3 | 0.038 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-aspartyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-isoleucyl)-5-fluoro-2'-deoxyuridine | 0.05 | 2.94 | 0.017 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-isoleucyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-leucyl)-5-fluoro-2'-deoxyuridine | 0.315 | 0.97 | 0.323 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-leucyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-lysyl)-5-fluoro-2'-deoxyuridine | 0.382 | 6.25 | 0.062 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-lysyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-phenylalanyl)-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole | 0.8 | 0.91 | 0.878 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-phenylalanyl)-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-phenylalanyl)-5-fluoro-2'-deoxyuridine | 0.623 | 0.46 | 1.355 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-phenylalanyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-prolyl)-5-fluoro-2'-deoxyuridine | 0.677 | 1.87 | 0.362 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-prolyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-(L-valyl)-5-fluoro-2'-deoxyuridine | 0.072 | 3.58 | 0.02 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-(L-valyl)-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | 5'-O-cinnamoyl-5-fluoro-2'-deoxyuridine | 1.375 | 0.63 | 2.193 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), 5'-O-cinnamoyl-5-fluoro-2'-deoxyuridine |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | irinotecan | 0.0092 | 4.21 | 0.0022 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), irinotecan |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | N-acetyl phenylalanine ethyl ester | 0.445 | 0.4 | 1.117 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), N-acetyl phenylalanine ethyl ester |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | p-nitrophenyl acetate | 20.15 | 0.52 | 38.66 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), p-nitrophenyl acetate |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | p-nitrophenyl butyrate | 27.42 | 0.14 | 195.8 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), p-nitrophenyl butyrate |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | phenylalanine benzyl ester | 0.078 | 0.08 | 0.998 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), phenylalanine benzyl ester |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | phenylalanine ethyl ester | 63.62 | 1.18 | 53.92 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), phenylalanine ethyl ester |
| liver carboxylesterase 1 (pCES1) | Sus scrofa (porcine) | valacyclovir | 0.285 | 8.81 | 0.032 | pH 7.4, 37 °C | Open record: liver carboxylesterase 1 (pCES1), valacyclovir |