Values CatLog read from this paper

Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase

PMID 16737955doi:10.1074/jbc.m602956200Open in Browse

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CatLog read 20 records (33 values) from this paper: NAD-dependent isocitrate dehydrogenase from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.41

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
NAD-dependent isocitrate dehydrogenase	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	30	0.07	429	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)
NAD-dependent isocitrate dehydrogenasevariant α-D206N	Homo sapiens	DL-isocitrate (trisodium salt)	—	3.5	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D206N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D206N	Homo sapiens	DL-isocitrate (trisodium salt)with 1 mM ADP (allosteric activator)	—	0.46	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D206N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D206N	Homo sapiens	DL-isocitrate (trisodium salt)	—	—	10.3	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D206N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D206N	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	36.8	0.14	263	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D206N, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)
NAD-dependent isocitrate dehydrogenasevariant α-D230C	Homo sapiens	DL-isocitrate (trisodium salt)	—	20	0.09	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D230C, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D230C	Homo sapiens	DL-isocitrate (trisodium salt)with 3 mM ADP (footnote b) (allosteric activator)	—	6.5	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D230C, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D230C	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	2.49	1.1	2	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D230C, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)
NAD-dependent isocitrate dehydrogenasevariant α-D234C	Homo sapiens	DL-isocitrate (trisodium salt)	—	3.4	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D234C, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D234C	Homo sapiens	DL-isocitrate (trisodium salt)with 1 mM ADP (allosteric activator)	—	0.01	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D234C, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D234C	Homo sapiens	DL-isocitrate (trisodium salt)	—	—	0.07	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D234C, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant α-D234C	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	0.27	0.04	7	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant α-D234C, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)
NAD-dependent isocitrate dehydrogenasevariant β-D217N	Homo sapiens	DL-isocitrate (trisodium salt)	—	5.1	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant β-D217N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant β-D217N	Homo sapiens	DL-isocitrate (trisodium salt)with 1 mM ADP (allosteric activator)	—	0.33	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant β-D217N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant β-D217N	Homo sapiens	DL-isocitrate (trisodium salt)	—	—	3.58	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant β-D217N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant β-D217N	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	19.6	0.68	29	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant β-D217N, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)
NAD-dependent isocitrate dehydrogenasevariant γ-D215N	Homo sapiens	DL-isocitrate (trisodium salt)	—	41	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant γ-D215N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant γ-D215N	Homo sapiens	DL-isocitrate (trisodium salt)with 5 mM ADP (footnote d) (allosteric activator)	—	2.16	—	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant γ-D215N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant γ-D215N	Homo sapiens	DL-isocitrate (trisodium salt)	—	—	0.29	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant γ-D215N, DL-isocitrate (trisodium salt)
NAD-dependent isocitrate dehydrogenasevariant γ-D215N	Homo sapiens	β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)	11.8	0.19	62	pH 7.2, 25 °C	Open record: NAD-dependent isocitrate dehydrogenase variant γ-D215N, β-NAD+ (nicotinamide adenine dinucleotide, oxidized form)