Values CatLog read from this paper
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
PMID 17727341doi:10.1042/bj20070970Open in Browse
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CatLog read 6 records (18 values) from this paper: PDE4C2 catalytic domain (PDE4C), PDE4D2 catalytic domain (PDE4D), PDE4A10 catalytic domain (PDE4A) and 1 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| PDE4A10 catalytic domain (PDE4A) | — | adenosine 3',5'-cyclic monophosphate | 6.7 | 0.0051 | 1.3 × 10³ | pH 7.5, 25 °C | Open record: PDE4A10 catalytic domain (PDE4A), adenosine 3',5'-cyclic monophosphate |
| PDE4B2B catalytic domain (PDE4B) | — | adenosine 3',5'-cyclic monophosphate | 1.56 | 0.0045 | 350 | pH 7.5, 25 °C | Open record: PDE4B2B catalytic domain (PDE4B), adenosine 3',5'-cyclic monophosphate |
| PDE4C2 catalytic domain (PDE4C) | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.66 | 8 × 10⁻⁴ | 850 | pH 7.5, 25 °C | Open record: PDE4C2 catalytic domain (PDE4C), adenosine 3',5'-cyclic monophosphate |
| PDE4C2 catalytic domain (PDE4C) | Homo sapiens | guanosine 3',5'-cyclic monophosphate | 0.48 | 0.24 | 2 | pH 7.5, 25 °C | Open record: PDE4C2 catalytic domain (PDE4C), guanosine 3',5'-cyclic monophosphate |
| PDE4D2 catalytic domain (PDE4D) | — | adenosine 3',5'-cyclic monophosphate | 5.4 | 0.0015 | 3.5 × 10³ | pH 7.5, 25 °C | Open record: PDE4D2 catalytic domain (PDE4D), adenosine 3',5'-cyclic monophosphate |
| PDE4D2 catalytic domain (PDE4D) | — | guanosine 3',5'-cyclic monophosphate | 1.19 | 0.427 | 2.8 | pH 7.5, 25 °C | Open record: PDE4D2 catalytic domain (PDE4D), guanosine 3',5'-cyclic monophosphate |