Values CatLog read from this paper
E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical…
PMID 18160520doi:10.1128/aac.01028-07Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 18 records (54 values) from this paper: β-lactamase TEM-149, β-lactamase TEM-149T182M.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | ampicillin | 5.4 | 0.005 | 1.08 × 10³ | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), ampicillin |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | aztreonam | 4.7 | 0.051 | 92 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), aztreonam |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | benzylpenicillin | 3.5 | 6 × 10⁻⁴ | 5.8 × 10³ | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), benzylpenicillin |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | cefazolin | 2.2 | 0.068 | 32 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), cefazolin |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | cefepime | 2.4 | 0.016 | 150 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), cefepime |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | cefotaxime | 0.07 | 0.043 | 1.6 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), cefotaxime |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | ceftazidime | 8.3 | 0.019 | 440 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), ceftazidime |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | nitrocefin | 7.4 | 0.02 | 370 | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), nitrocefin |
| β-lactamase TEM-149variant TEM-149 (E104K/R164S/M182T/E240V) | — | piperacillin | 2.7 | 0.0014 | 1.92 × 10³ | pH 7, 25 °C | Open record: β-lactamase TEM-149 variant TEM-149 (E104K/R164S/M182T/E240V), piperacillin |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | ampicillin | 2.4 | 0.019 | 127 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), ampicillin |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | aztreonam | 3.6 | 0.027 | 130 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), aztreonam |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | benzylpenicillin | 10.5 | 7 × 10⁻⁴ | 1.5 × 10⁴ | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), benzylpenicillin |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | cefazolin | 0.56 | 0.035 | 16 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), cefazolin |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | cefepime | 0.43 | 0.03 | 14 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), cefepime |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | cefotaxime | 0.41 | 0.032 | 13 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), cefotaxime |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | ceftazidime | 8.3 | 0.026 | 320 | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), ceftazidime |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | nitrocefin | 26 | 0.025 | 1.04 × 10³ | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), nitrocefin |
| β-lactamase TEM-149T182Mvariant TEM-149T182M (E104K/R164S/E240V) | — | piperacillin | 5 | 0.0034 | 1.47 × 10³ | pH 7, 25 °C | Open record: β-lactamase TEM-149T182M variant TEM-149T182M (E104K/R164S/E240V), piperacillin |