Values CatLog read from this paper
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants
PMID 18511072doi:10.1016/j.jmb.2008.04.066Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 24 records (48 values) from this paper: GST P1-1 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| GST P1-1 | Homo sapiens | 1-chloro-2,4-dinitrobenzene | 79 | 1.2 | 66 | pH 6.5, 25 °C | Open record: GST P1-1, 1-chloro-2,4-dinitrobenzene |
| GST P1-1 | Homo sapiens | 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole | 1 | 0.004 | 250 | pH 5, 25 °C | Open record: GST P1-1, 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole |
| GST P1-1 | Homo sapiens | ethacrynic acid | 3.2 | 0.21 | 15 | pH 6.5, 25 °C | Open record: GST P1-1, ethacrynic acid |
| GST P1-1 | Homo sapiens | glutathione0.02-1 mM GSH at a fixed 1 mM CDNB; cosubstrate CDNB | — | 0.15 | — | pH 6.5, 25 °C | Open record: GST P1-1, glutathione |
| GST P1-1 | Homo sapiens | glutathione0.04-1 mM GSH at a fixed 0.5 mM EA; cosubstrate EA | — | 0.17 | — | pH 6.5, 25 °C | Open record: GST P1-1, glutathione |
| GST P1-1 | Homo sapiens | glutathione | — | 0.008 | — | pH 5, 25 °C | Open record: GST P1-1, glutathione |
| GST P1-1variant A113V | Homo sapiens | 1-chloro-2,4-dinitrobenzene | 79 | 1.4 | 56 | pH 6.5, 25 °C | Open record: GST P1-1 variant A113V, 1-chloro-2,4-dinitrobenzene |
| GST P1-1variant A113V | Homo sapiens | 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole | 1.3 | 0.011 | 118 | pH 5, 25 °C | Open record: GST P1-1 variant A113V, 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole |
| GST P1-1variant A113V | Homo sapiens | ethacrynic acid | 1.3 | 0.09 | 14 | pH 6.5, 25 °C | Open record: GST P1-1 variant A113V, ethacrynic acid |
| GST P1-1variant A113V | Homo sapiens | glutathione0.02-1 mM GSH at a fixed 1 mM CDNB; cosubstrate CDNB | — | 0.13 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant A113V, glutathione |
| GST P1-1variant A113V | Homo sapiens | glutathione0.04-1 mM GSH at a fixed 0.5 mM EA; cosubstrate EA | — | 0.21 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant A113V, glutathione |
| GST P1-1variant A113V | Homo sapiens | glutathione | — | 0.014 | — | pH 5, 25 °C | Open record: GST P1-1 variant A113V, glutathione |
| GST P1-1variant I104V | Homo sapiens | 1-chloro-2,4-dinitrobenzene | 52 | 2.9 | 18 | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V, 1-chloro-2,4-dinitrobenzene |
| GST P1-1variant I104V | Homo sapiens | 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole | 0.26 | 0.007 | 37 | pH 5, 25 °C | Open record: GST P1-1 variant I104V, 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole |
| GST P1-1variant I104V | Homo sapiens | ethacrynic acid | 1.8 | 0.08 | 22.5 | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V, ethacrynic acid |
| GST P1-1variant I104V | Homo sapiens | glutathione0.02-1 mM GSH at a fixed 1 mM CDNB; cosubstrate CDNB | — | 0.11 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V, glutathione |
| GST P1-1variant I104V | Homo sapiens | glutathione0.04-1 mM GSH at a fixed 0.5 mM EA; cosubstrate EA | — | 0.17 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V, glutathione |
| GST P1-1variant I104V | Homo sapiens | glutathione | — | 0.007 | — | pH 5, 25 °C | Open record: GST P1-1 variant I104V, glutathione |
| GST P1-1variant I104V/A113V | Homo sapiens | 1-chloro-2,4-dinitrobenzene | 48 | 2.3 | 21 | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V/A113V, 1-chloro-2,4-dinitrobenzene |
| GST P1-1variant I104V/A113V | Homo sapiens | 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole | 0.52 | 0.002 | 260 | pH 5, 25 °C | Open record: GST P1-1 variant I104V/A113V, 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole |
| GST P1-1variant I104V/A113V | Homo sapiens | ethacrynic acid | 2.3 | 0.06 | 38 | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V/A113V, ethacrynic acid |
| GST P1-1variant I104V/A113V | Homo sapiens | glutathione0.02-1 mM GSH at a fixed 1 mM CDNB; cosubstrate CDNB | — | 0.08 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V/A113V, glutathione |
| GST P1-1variant I104V/A113V | Homo sapiens | glutathione0.04-1 mM GSH at a fixed 0.5 mM EA; cosubstrate EA | — | 0.2 | — | pH 6.5, 25 °C | Open record: GST P1-1 variant I104V/A113V, glutathione |
| GST P1-1variant I104V/A113V | Homo sapiens | glutathione | — | 0.003 | — | pH 5, 25 °C | Open record: GST P1-1 variant I104V/A113V, glutathione |