Values CatLog read from this paper
Directed evolution of a histone acetyltransferase--enhancing thermostability, whilst maintaining catalytic activity and substrate specificity
PMID 18959749doi:10.1111/j.1742-4658.2008.06689.xOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 29 records (47 values) from this paper: P/CAF histone acetyltransferase from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 18 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| P/CAF histone acetyltransferase | Homo sapiens | acetyl-coenzyme A | — | 2.8 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase, acetyl-coenzyme A |
| P/CAF histone acetyltransferase | Homo sapiens | ARTKQTARKSTGGKAPRKQLCTable 3 | 0.2 | 0.053 | 3.8 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferase | Homo sapiens | ARTKQTARKSTGGKAPRKQLCin the text | — | — | 3.774 | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferase | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGKTable 3 | 0.0048 | 0.19 | 0.025 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferase | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGKin the text | — | — | 0.025 | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant D601G | Homo sapiens | acetyl-coenzyme A | — | 3.4 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D601G, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant D601G | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.2 | 0.055 | 3.6 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D601G, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant D601G | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0055 | 0.25 | 0.022 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D601G, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant D639E | Homo sapiens | acetyl-coenzyme A | — | 2.7 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D639E, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant D639E | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.2 | 0.039 | 5.1 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D639E, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant D639E | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0058 | 0.15 | 0.039 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant D639E, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant L503P | Homo sapiens | acetyl-coenzyme A | — | 3.3 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant L503P | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.2 | 0.054 | 3.7 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant L503P | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0053 | 0.21 | 0.025 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant L503P/D601G/Y612C | Homo sapiens | acetyl-coenzyme A | — | 2.7 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P/D601G/Y612C, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant L503P/D601G/Y612C | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.2 | 0.064 | 3.1 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P/D601G/Y612C, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant L503P/D601G/Y612C | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.003 | 0.11 | 0.027 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant L503P/D601G/Y612C, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant V582A | Homo sapiens | acetyl-coenzyme A | — | 3.6 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant V582A | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.18 | 0.56 | 0.33 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant V582A | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0048 | 0.5 | 0.0097 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant V582A/D639E | Homo sapiens | acetyl-coenzyme A | — | 3.4 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A/D639E, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant V582A/D639E | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.22 | 0.46 | 0.47 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A/D639E, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant V582A/D639E | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0062 | 0.31 | 0.020 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant V582A/D639E, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant Y612C | Homo sapiens | acetyl-coenzyme A | — | 4.1 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant Y612C | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.18 | 0.165 | 1.1 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant Y612C | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0018 | 0.12 | 0.015 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C, SGRGKGGKGLGKGGAKRHRKVGGK |
| P/CAF histone acetyltransferasevariant Y612C/P655R | Homo sapiens | acetyl-coenzyme A | — | 2.9 × 10⁻⁴ | — | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C/P655R, acetyl-coenzyme A |
| P/CAF histone acetyltransferasevariant Y612C/P655R | Homo sapiens | ARTKQTARKSTGGKAPRKQLC | 0.2 | 0.062 | 3.2 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C/P655R, ARTKQTARKSTGGKAPRKQLC |
| P/CAF histone acetyltransferasevariant Y612C/P655R | Homo sapiens | SGRGKGGKGLGKGGAKRHRKVGGK | 0.0035 | 0.14 | 0.025 calc. | pH 7.5, 25 °C | Open record: P/CAF histone acetyltransferase variant Y612C/P655R, SGRGKGGKGLGKGGAKRHRKVGGK |