Values CatLog read from this paper
Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity
PMID 19015366doi:10.1128/aac.00275-08Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 43 records (115 values) from this paper: methionyl-tRNA synthetase (MetRS), human mitochondrial methionyl-tRNA synthetase (hmMetRS), methionyl-tRNA synthetase (MetRS2 subtype) and 1 more from Staphylococcus aureus, Homo sapiens, Haemophilus influenzae and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| human mitochondrial methionyl-tRNA synthetase (hmMetRS) | Homo sapiens | ATP | — | 0.085 | — | pH 8, 30 °C | Open record: human mitochondrial methionyl-tRNA synthetase (hmMetRS), ATP |
| human mitochondrial methionyl-tRNA synthetase (hmMetRS) | Homo sapiens | L-methionine | — | 0.02 | — | pH 8, 30 °C | Open record: human mitochondrial methionyl-tRNA synthetase (hmMetRS), L-methionine |
| methionyl-tRNA synthetase (MetRS) | Staphylococcus aureus | ATP | 25 | 0.5 | 50 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS), ATP |
| methionyl-tRNA synthetase (MetRS) | Staphylococcus aureus | L-methionineATP:PPi exchange assay (Table 3 footnote a): 100 mM Tris-HCl | 25 | 0.1 | 250 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS), L-methionine |
| methionyl-tRNA synthetase (MetRS) | Staphylococcus aureus | L-methionineATP:PPi exchange assay: 100 mM Tris-HCl | — | 0.33 | — | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS), L-methionine |
| methionyl-tRNA synthetase (MetRS) | Staphylococcus aureus | tRNA | 0.49 | 0.001 | 490 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS), tRNA |
| methionyl-tRNA synthetase (MetRS)variant A247E | Staphylococcus aureus | ATP | 11 | 1.14 | 10 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant A247E, ATP |
| methionyl-tRNA synthetase (MetRS)variant A247E | Staphylococcus aureus | L-methionine | 11 | 0.22 | 50 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant A247E, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant A247E | Staphylococcus aureus | tRNA | 0.057 | 0.0013 | 44 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant A247E, tRNA |
| methionyl-tRNA synthetase (MetRS)variant G223C | Staphylococcus aureus | ATP | 10 | 0.75 | 13 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G223C, ATP |
| methionyl-tRNA synthetase (MetRS)variant G223C | Staphylococcus aureus | L-methionine | 10 | 0.68 | 10 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G223C, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant G223C | Staphylococcus aureus | tRNA | 0.037 | 0.0025 | 15 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G223C, tRNA |
| methionyl-tRNA synthetase (MetRS)variant G54A/A64P | Staphylococcus aureus | ATP | 1 | 0.76 | 1 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54A/A64P, ATP |
| methionyl-tRNA synthetase (MetRS)variant G54A/A64P | Staphylococcus aureus | L-methionine | 1 | 1.07 | 1 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54A/A64P, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant G54A/A64P | Staphylococcus aureus | tRNA | 0.001 | 5.7 × 10⁻⁴ | 2 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54A/A64P, tRNA |
| methionyl-tRNA synthetase (MetRS)variant G54S | Staphylococcus aureus | ATP | 5 | 0.5 | 10 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54S, ATP |
| methionyl-tRNA synthetase (MetRS)variant G54S | Staphylococcus aureus | L-methionine | 5 | 0.075 | 70 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54S, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant G54S | Staphylococcus aureus | tRNA | 0.009 | 2.7 × 10⁻⁴ | 33 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant G54S, tRNA |
| methionyl-tRNA synthetase (MetRS)variant I57N | Staphylococcus aureus | ATP | 14 | 0.82 | 17 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N, ATP |
| methionyl-tRNA synthetase (MetRS)variant I57N | Staphylococcus aureus | L-methionine | 14 | 0.025 | 560 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant I57N | Staphylococcus aureus | tRNA | 0.023 | 9.3 × 10⁻⁴ | 25 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N, tRNA |
| methionyl-tRNA synthetase (MetRS)variant I57N/A247E | Staphylococcus aureus | ATP | 11 | 2.23 | 5 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/A247E, ATP |
| methionyl-tRNA synthetase (MetRS)variant I57N/A247E | Staphylococcus aureus | L-methionine | 11 | 0.25 | 40 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/A247E, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant I57N/A247E | Staphylococcus aureus | tRNA | 0.008 | 4.5 × 10⁻⁴ | 18 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/A247E, tRNA |
| methionyl-tRNA synthetase (MetRS)variant I57N/G54S | Staphylococcus aureus | ATP | 6 | 0.765 | 8 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/G54S, ATP |
| methionyl-tRNA synthetase (MetRS)variant I57N/G54S | Staphylococcus aureus | L-methionine | 6 | 0.36 | 20 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/G54S, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant I57N/G54S | Staphylococcus aureus | tRNA | 0.002 | 4.1 × 10⁻⁴ | 5 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/G54S, tRNA |
| methionyl-tRNA synthetase (MetRS)variant I57N/I238F | Staphylococcus aureus | ATP | 13 | 1.61 | 8 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/I238F, ATP |
| methionyl-tRNA synthetase (MetRS)variant I57N/I238F | Staphylococcus aureus | L-methionine | 13 | 0.085 | 150 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/I238F, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant I57N/I238F | Staphylococcus aureus | tRNA | 0.066 | 8.9 × 10⁻⁴ | 74 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/I238F, tRNA |
| methionyl-tRNA synthetase (MetRS)variant I57N/V242F | Staphylococcus aureus | ATP | 14 | 0.81 | 17 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/V242F, ATP |
| methionyl-tRNA synthetase (MetRS)variant I57N/V242F | Staphylococcus aureus | L-methionine | 14 | 0.02 | 700 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/V242F, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant I57N/V242F | Staphylococcus aureus | tRNA | 0.124 | 0.01 | 12 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant I57N/V242F, tRNA |
| methionyl-tRNA synthetase (MetRS)variant L213W | Staphylococcus aureus | ATP | 10 | 0.595 | 17 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant L213W, ATP |
| methionyl-tRNA synthetase (MetRS)variant L213W | Staphylococcus aureus | L-methionine | 10 | 0.1 | 100 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant L213W, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant L213W | Staphylococcus aureus | tRNA | 0.54 | 0.0017 | 320 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant L213W, tRNA |
| methionyl-tRNA synthetase (MetRS)variant V108M | Staphylococcus aureus | ATP | 15 | 0.65 | 23 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant V108M, ATP |
| methionyl-tRNA synthetase (MetRS)variant V108M | Staphylococcus aureus | L-methionine | 15 | 0.14 | 110 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant V108M, L-methionine |
| methionyl-tRNA synthetase (MetRS)variant V108M | Staphylococcus aureus | tRNA | 0.74 | 0.0032 | 230 | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS) variant V108M, tRNA |
| methionyl-tRNA synthetase (MetRS2 subtype) | Haemophilus influenzae | ATP | — | 1.2 | — | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS2 subtype), ATP |
| methionyl-tRNA synthetase (MetRS2 subtype) | Haemophilus influenzae | L-methionine | — | 0.25 | — | pH 8, 30 °C | Open record: methionyl-tRNA synthetase (MetRS2 subtype), L-methionine |
| methionyl-tRNA synthetase type 1 (MetRS1) | Streptococcus pneumoniae | ATP | — | 0.514 | — | pH 8, 30 °C | Open record: methionyl-tRNA synthetase type 1 (MetRS1), ATP |
| methionyl-tRNA synthetase type 1 (MetRS1) | Streptococcus pneumoniae | L-methionine | — | 0.053 | — | pH 8, 30 °C | Open record: methionyl-tRNA synthetase type 1 (MetRS1), L-methionine |