Values CatLog read from this paper

Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases

PMID 19860471doi:10.1021/bi901548cOpen in Browse

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CatLog read 59 records (177 values) from this paper: OXA-10 class D β-lactamase from Pseudomonas aeruginosa.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.5.2.6

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	ampicillinno added NaHCO3	160	0.18	900	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, ampicillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	ampicillin50 mM NaHCO3 added; [CO2] = 870 μM	220	0.035	6.2 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, ampicillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	benzylpenicillinno added NaHCO3	85	0.055	1.5 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, benzylpenicillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	benzylpenicillin50 mM NaHCO3 added; [CO2] = 870 μM	120	0.02	6 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, benzylpenicillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cephaloridineno added NaHCO3	35	2	18	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cephaloridine
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cephaloridine50 mM NaHCO3 added; [CO2] = 870 μM	70	0.4	180	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cephaloridine
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cephalothinno added NaHCO3	2	0.005	400	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cephalothin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cephalothin50 mM NaHCO3 added; [CO2] = 870 μM	2.5	0.007	380	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cephalothin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cloxacillinno added NaHCO3	500	0.25	2 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cloxacillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	cloxacillin50 mM NaHCO3 added; [CO2] = 870 μM	120	0.11	1 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, cloxacillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	nitrocefinno added NaHCO3	1.3 × 10³	0.025	5.2 × 10⁴	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, nitrocefin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	nitrocefin50 mM NaHCO3 added; [CO2] = 870 μM	1.7 × 10³	0.01	1.7 × 10⁵	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, nitrocefin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	oxacillinno added NaHCO3	600	0.2	3 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, oxacillin
OXA-10 class D β-lactamase	Pseudomonas aeruginosa	oxacillin50 mM NaHCO3 added; [CO2] = 870 μM	300	0.1	3 × 10³	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase, oxacillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	ampicillinno added NaHCO3	0.07	0.06	1.15	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, ampicillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	ampicillin50 mM NaHCO3 added; [CO2] = 870 μM	1.4	0.03	47	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, ampicillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	benzylpenicillinno added NaHCO3	0.08	0.15	0.53	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, benzylpenicillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	benzylpenicillin50 mM NaHCO3 added; [CO2] = 870 μM	0.7	0.06	12	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, benzylpenicillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cephaloridineno added NaHCO3	0.004	0.45	0.01	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cephaloridine
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cephaloridine50 mM NaHCO3 added; [CO2] = 870 μM	0.015	0.06	0.25	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cephaloridine
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cephalothinno added NaHCO3	0.003	0.21	0.014	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cephalothin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cephalothin50 mM NaHCO3 added; [CO2] = 870 μM	0.012	0.04	0.3	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cephalothin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cloxacillinno added NaHCO3	0.2	0.1	2	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cloxacillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	cloxacillin50 mM NaHCO3 added; [CO2] = 870 μM	4	0.03	130	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, cloxacillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	nitrocefinno added NaHCO3	0.6	0.11	5.5	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, nitrocefin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	nitrocefin50 mM NaHCO3 added; [CO2] = 870 μM	6	0.035	170	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, nitrocefin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	oxacillinno added NaHCO3	0.25	0.06	4.2	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, oxacillin
OXA-10 class D β-lactamasevariant W154A	Pseudomonas aeruginosa	oxacillin50 mM NaHCO3 added; [CO2] = 870 μM	4.5	0.02	23	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154A, oxacillin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	ampicillin	2.4	0.125	19	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, ampicillin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	benzylpenicillin	2.5	0.1	25	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, benzylpenicillin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	cephaloridine	1.3	0.05	26	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, cephaloridine
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	cephalothin	8	0.025	320	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, cephalothin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	cloxacillin	1.8	0.14	12	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, cloxacillin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	nitrocefin	2	0.05	30	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, nitrocefin
OXA-10 class D β-lactamasevariant W154F	Pseudomonas aeruginosa	oxacillin	2	0.125	16	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154F, oxacillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	ampicillinno added NaHCO3	0.0126	0.23	0.056	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, ampicillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	ampicillin50 mM NaHCO3 added; [CO2] = 870 μM	0.132	0.04	3.3	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, ampicillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	benzylpenicillinno added NaHCO3	0.04	0.6	0.067	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, benzylpenicillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	benzylpenicillin50 mM NaHCO3 added; [CO2] = 870 μM	0.13	0.01	13	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, benzylpenicillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cephaloridineno added NaHCO3	0.0036	0.29	0.012	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cephaloridine
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cephaloridine50 mM NaHCO3 added; [CO2] = 870 μM	0.002	0.065	0.03	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cephaloridine
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cephalothinno added NaHCO3	0.0023	0.45	0.005	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cephalothin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cephalothin50 mM NaHCO3 added; [CO2] = 870 μM	0.003	0.21	0.014	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cephalothin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cloxacillinno added NaHCO3	2.5	0.22	13	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cloxacillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	cloxacillin50 mM NaHCO3 added; [CO2] = 870 μM	3.5	0.2	18	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, cloxacillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	nitrocefinno added NaHCO3	4	0.1	40	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, nitrocefin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	nitrocefin50 mM NaHCO3 added; [CO2] = 870 μM	8	0.06	130	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, nitrocefin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	oxacillinno added NaHCO3	3.5	0.2	17.5	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, oxacillin
OXA-10 class D β-lactamasevariant W154G	Pseudomonas aeruginosa	oxacillin50 mM NaHCO3 added; [CO2] = 870 μM	4	0.1	40	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154G, oxacillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	ampicillinno added NaHCO3	3	0.25	13	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, ampicillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	ampicillin50 mM NaHCO3 added; [CO2] = 870 μM	18	0.15	120	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, ampicillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	benzylpenicillinno added NaHCO3	1.5	0.017	80	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, benzylpenicillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	benzylpenicillin50 mM NaHCO3 added; [CO2] = 870 μM	4	0.07	57	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, benzylpenicillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	cephalothinno added NaHCO3	0.1	0.005	20	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, cephalothin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	cephalothin50 mM NaHCO3 added; [CO2] = 870 μM	0.15	0.004	35	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, cephalothin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	nitrocefinno added NaHCO3	1	0.01	100	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, nitrocefin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	nitrocefin50 mM NaHCO3 added; [CO2] = 870 μM	2.5	0.013	190	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, nitrocefin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	oxacillinno added NaHCO3	35	0.65	53	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, oxacillin
OXA-10 class D β-lactamasevariant W154H	Pseudomonas aeruginosa	oxacillin50 mM NaHCO3 added; [CO2] = 870 μM	90	0.13	700	pH 7, 25 °C	Open record: OXA-10 class D β-lactamase variant W154H, oxacillin