Values CatLog read from this paper
Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
PMID 20435888doi:10.1074/jbc.m110.115386Open in Browse
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CatLog read 18 records (18 values) from this paper: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | DL-isocitrateno ADP | — | 2 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 0.05 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | DL-isocitrateno ADP | — | 7.5 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 2.1 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | NAD+ | — | 0.06 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, NAD+ |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer | Homo sapiens | NAD+ | — | 0.08 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer, NAD+ |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y126E (α subunit) | Homo sapiens | DL-isocitrateno ADP | — | 0.3 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y126E (α subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y126E (α subunit) | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 0.07 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y126E (α subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y126E (α subunit) | Homo sapiens | NAD+ | — | 2.33 | — | pH 6.1, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y126E (α subunit), NAD+ |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137E (β subunit) | Homo sapiens | DL-isocitrateno ADP | — | 3.4 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137E (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137E (β subunit) | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 0.09 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137E (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137E (β subunit) | Homo sapiens | NAD+ | — | 0.09 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137E (β subunit), NAD+ |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137F (β subunit) | Homo sapiens | DL-isocitrateno ADP | — | 1.8 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137F (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137F (β subunit) | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 0.28 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137F (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137F (β subunit) | Homo sapiens | NAD+ | — | 0.12 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137F (β subunit), NAD+ |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137S (β subunit) | Homo sapiens | DL-isocitrateno ADP | — | 1.2 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137S (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137S (β subunit) | Homo sapiens | DL-isocitratewith 1 mM ADP (allosteric activator) | — | 0.92 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137S (β subunit), DL-isocitrate |
| NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramervariant Y137S (β subunit) | Homo sapiens | NAD+ | — | 0.63 | — | pH 7.2, 25 °C | Open record: NAD-dependent isocitrate dehydrogenase (NAD-IDH) α2βγ heterotetramer variant Y137S (β subunit), NAD+ |