Values CatLog read from this paper
Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability
PMID 25324420doi:10.1093/jac/dku403Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 56 records (168 values) from this paper: New Delhi metallo-β-lactamase (NDM), New Delhi metallo-β-lactamase (NDM) NDM-1.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | ampicillin | 724 | 0.258 | 2.8 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | cefalotin | 53 | 0.013 | 4.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | cefoxitin | 6 | 0.05 | 130 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | ceftazidime | 23 | 0.115 | 200 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | doripenem | 170 | 0.083 | 2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | imipenem | 757 | 0.082 | 9.2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | meropenem | 238 | 0.058 | 4.2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-3 (D95N) | — | nitrocefin | 30 | 0.004 | 7.5 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-3 (D95N), nitrocefin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | ampicillin | 900 | 0.305 | 2.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | cefalotin | 45 | 0.011 | 4.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | cefoxitin | 14 | 0.063 | 220 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | ceftazidime | 28 | 0.133 | 210 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | doripenem | 743 | 0.125 | 6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | imipenem | 252 | 0.062 | 4.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | meropenem | 583 | 0.119 | 4.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-4 (M154L) | — | nitrocefin | 38 | 0.004 | 6.3 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-4 (M154L), nitrocefin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | ampicillin | 408 | 0.156 | 2.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | cefalotin | 25 | 0.015 | 1.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | cefoxitin | 4 | 0.027 | 140 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | ceftazidime | 15 | 0.086 | 180 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | doripenem | 570 | 0.126 | 4.5 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | imipenem | 332 | 0.148 | 2.2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | meropenem | 413 | 0.099 | 4.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-5 (V88L/M154L) | — | nitrocefin | 33 | 0.006 | 5.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-5 (V88L/M154L), nitrocefin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | ampicillin | 1375 | 0.455 | 3 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | cefalotin | 63 | 0.01 | 6.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | cefoxitin | 18 | 0.107 | 170 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | ceftazidime | 29 | 0.144 | 200 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | doripenem | 1032 | 0.119 | 8.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | imipenem | 355 | 0.062 | 5.8 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | meropenem | 362 | 0.049 | 7.4 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-6 (A233V) | — | nitrocefin | 49 | 0.008 | 6.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-6 (A233V), nitrocefin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | ampicillin | 477 | 0.207 | 2.3 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | cefalotin | 18 | 0.011 | 1.5 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | cefoxitin | 4 | 0.023 | 150 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | ceftazidime | 16 | 0.079 | 200 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | doripenem | 348 | 0.064 | 5.4 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | imipenem | 127 | 0.056 | 2.3 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | meropenem | 194 | 0.045 | 4.3 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-7 (D130N/M154L) | — | nitrocefin | 15 | 0.005 | 3.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-7 (D130N/M154L), nitrocefin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | ampicillin | 273 | 0.229 | 1.2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), ampicillin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | cefalotin | 9 | 0.005 | 1.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), cefalotin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | cefoxitin | 3 | 0.016 | 180 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), cefoxitin |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | ceftazidime | 5 | 0.019 | 260 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), ceftazidime |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | doripenem | 267.4 | 0.151 | 1.7 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), doripenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | imipenem | 54 | 0.02 | 2.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), imipenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | meropenem | 141.7 | 0.054 | 2.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), meropenem |
| New Delhi metallo-β-lactamase (NDM)variant NDM-8 (D130G/M154L) | — | nitrocefin | 44 | 0.004 | 1.09 × 10⁴ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) variant NDM-8 (D130G/M154L), nitrocefin |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | ampicillin | 447 | 0.11 | 4.1 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, ampicillin |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | cefalotin | 75 | 0.029 | 2.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, cefalotin |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | cefoxitin | 10 | 0.043 | 230 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, cefoxitin |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | ceftazidime | 24 | 0.1 | 230 | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, ceftazidime |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | doripenem | 226 | 0.119 | 1.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, doripenem |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | imipenem | 600 | 0.078 | 7.6 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, imipenem |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | meropenem | 301 | 0.057 | 5.2 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, meropenem |
| New Delhi metallo-β-lactamase (NDM) NDM-1 | — | nitrocefin | 65 | 0.011 | 5.9 × 10³ | pH 7.2, 25 °C | Open record: New Delhi metallo-β-lactamase (NDM) NDM-1, nitrocefin |