Values CatLog read from this paper
Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
PMID 29503023doi:10.1016/j.bmcl.2018.02.035Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 8 records (8 values) from this paper: human carboxylesterase 1 (hCES1b, also referred to as CES1A1) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin (R)-1-phenylpropyl ester ((R)-2f) | — | 2.9 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin (R)-1-phenylpropyl ester ((R)-2f) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin (R)-sec-butyl ester ((R)-2b) | — | 10.1 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin (R)-sec-butyl ester ((R)-2b) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin (S)-1-phenylpropyl ester ((S)-2f) | — | 6.5 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin (S)-1-phenylpropyl ester ((S)-2f) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin (S)-sec-butyl ester ((S)-2b) | — | 48.5 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin (S)-sec-butyl ester ((S)-2b) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin isobutyl ester (2c) | — | 13.7 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin isobutyl ester (2c) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin n-butyl ester (2a) | — | 4.4 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin n-butyl ester (2a) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin n-butyl thioester (2g) | — | 2.1 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin n-butyl thioester (2g) | |
| human carboxylesterase 1 (hCES1b, also referred to as CES1A1) | Homo sapiens | indomethacin neopentyl ester (2e) | — | 4.6 | — | Open record: human carboxylesterase 1 (hCES1b, also referred to as CES1A1), indomethacin neopentyl ester (2e) |