CatLogenzyme kinetics catalog

Values CatLog read from this paper

Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1

PMID 29791483doi:10.1371/journal.pone.0197635Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 62 records (66 values) from this paper: Tk-PTP (protein tyrosine phosphatase) from Thermococcus kodakaraensis.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
Tk-PTP (protein tyrosine phosphatase)Thermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate4.740.7196.59pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)Thermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate300.276109pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.0415——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.0666—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.623pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate1.29——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.0274—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——47.1pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.0143——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.56—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.255pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate2.92——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.252—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63NThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——11.6pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.0652——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.466—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.14pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.688——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.223—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant D63N/E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——3.09pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.591——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.0658—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——8.98pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate3.83——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.023—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——167pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.197——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.862—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.229pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate2.97——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.251—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132LThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——11.8pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate5.64——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.307—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——18.4pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate8.82——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.15—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant E132QThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——58.8pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate4.17——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.0682—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——61.1pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate35.8——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.106—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant G95AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——338pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.102——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.363—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.281pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.46——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.135—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant Q136AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——3.41pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.248——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.611—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.406pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate1.59——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.301—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124AThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——5.28pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.0371——pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.363—pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.102pH 5, 20 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate0.188——pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate—0.258—pH 5, 60 °COpen
Tk-PTP (protein tyrosine phosphatase)variant R124EThermococcus kodakaraensis6,8-difluoro-4-methylumbelliferyl phosphate——0.729pH 5, 60 °COpen