Values CatLog read from this paper
A survey of the kinetic parameters of class C beta-lactamases. Cephalosporins and other beta-lactam compounds
PMID 3264155doi:10.1042/bj2550123Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 86 records (167 values) from this paper: class C beta-lactamase (cephalosporinase), class C β-lactamase from Enterobacter cloacae, Escherichia coli, Pseudomonas aeruginosa and 2 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 1 kcat/Km value marked “calc.” from kcat and Km; no printed kcat/Km was read for that record.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | aztreonamaztreonam behaves as a transient inactivator | — | — | 180 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | aztreonamaztreonam behaves as a transient inactivator | 3.2 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | aztreonam | 2 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | aztreonamaztreonam behaves as a transient inactivator | — | 1.4 × 10⁻⁶ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cefazolin | 5 × 10³ | 0.6 | 8 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefazolin |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cefotaxime | 0.017 | 5 × 10⁻⁶ | 3.4 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefotaxime |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cefoxitin | 0.32 | 2.5 × 10⁻⁴ | 1.3 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefoxitin |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cefuroxime | 0.04 | 2 × 10⁻⁵ | 2 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefuroxime |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cephalexin | 150 | 0.012 | 1.25 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cephaloridine | 700 | 0.035 | 2 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephaloridine |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | cephalothin | 210 | 0.013 | 1.6 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalothin |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | imipenem | — | — | 140 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | imipenem | 0.016 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | imipenem | — | 8.5 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Citrobacter freundii | nitrocefin | 330 | 0.012 | 2.8 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), nitrocefin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | — | — | 260 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | 4.4 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonam | 2 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | — | 1.2 × 10⁻⁶ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | — | — | 290 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | 3.5 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonam | 3 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | aztreonamaztreonam behaves as a transient inactivator | — | 1.1 × 10⁻⁶ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | camuronam | 0.001 | — | 40 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), camuronam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefazolinlike another record | 3 × 10³ | 1.5 | 2 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefazolin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefazolinlike another record | 3 × 10³ | 1.5 | 2 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefazolin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefotaxime | 0.015 | 1 × 10⁻⁵ | 1.5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefotaxime |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefotaxime | 0.01 | 1 × 10⁻⁵ | 1 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefotaxime |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefoxitin | 0.06 | 2.4 × 10⁻⁵ | 2.5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefoxitin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefoxitin | 0.08 | 2 × 10⁻⁵ | 4 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefoxitin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefuroximelike another record | 0.05 | 1.6 × 10⁻⁵ | 3.1 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefuroxime |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cefuroximelike another record | 0.05 | 1.6 × 10⁻⁵ | 3.1 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefuroxime |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephalexin | 70 | 0.01 | 7 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephalexin | 72 | 0.0085 | 8.5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephaloridine | 700 | 0.07 | 1 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephaloridine |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephaloridine | 600 | 0.075 | 8 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephaloridine |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephalothin | 200 | 0.009 | 2 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalothin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | cephalothin | 180 | 0.009 | 2 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalothin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | — | — | 60 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | 0.003 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | — | 4 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | — | — | 145 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | 0.0031 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | imipenem | — | 2.5 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | moxalactam | 0.009 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), moxalactam |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | nitrocefin | 780 | 0.025 | 3.1 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), nitrocefin |
| class C beta-lactamase (cephalosporinase) | Enterobacter cloacae | nitrocefin | 780 | 0.023 | 3.4 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), nitrocefin |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | aztreonam | — | — | 135 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | aztreonam | 1.6 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | aztreonam | — | 1.2 × 10⁻⁶ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cefazolin | 150 | 0.4 | 400 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefazolin |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cefotaxime | 0.17 | 0.0017 | 100 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefotaxime |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cefoxitin | 0.2 | 6.5 × 10⁻⁴ | 300 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefoxitin |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cefuroxime | 0.15 | 1.5 × 10⁻⁴ | 1 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefuroxime |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cephalexin | 38 | 0.004 | 9.5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cephaloridine | 130 | 0.17 | 770 calc. | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephaloridine |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | cephalothin | 300 | 0.042 | 7 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalothin |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | imipenem | — | — | 11.2 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | imipenem | 0.01 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | imipenem | — | 8 × 10⁻⁴ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | moxalactam | 0.01 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), moxalactam |
| class C beta-lactamase (cephalosporinase) | Escherichia coli | nitrocefin | 490 | 0.5 | 1 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), nitrocefin |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | aztreonamaztreonam behaves as a transient inactivator | — | — | 58 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | aztreonamaztreonam behaves as a transient inactivator | 0.0023 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | aztreonam | 0.004 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | aztreonamaztreonam behaves as a transient inactivator | — | 5 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | camuronam | 0.0036 | — | 4 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), camuronam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cefotaxime | 0.15 | 2 × 10⁻⁴ | 750 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefotaxime |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cefoxitin | 0.12 | 5 × 10⁻⁵ | 2.4 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefoxitin |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cefuroxime | 0.05 | 2 × 10⁻⁵ | 2.5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cefuroxime |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cephalexin | 27 | 0.003 | 9 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cephaloridine | 110 | 0.02 | 5 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephaloridine |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | cephalothin | 430 | 0.017 | 2.5 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalothin |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | imipenem | — | — | 88 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | imipenem | 0.03 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | moxalactam | 0.006 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), moxalactam |
| class C beta-lactamase (cephalosporinase) | Pseudomonas aeruginosa | nitrocefin | 742 | 0.027 | 2.7 × 10⁴ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), nitrocefin |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | aztreonam | — | — | 12 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | aztreonam | 7 × 10⁻⁴ | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | aztreonam | — | 5.8 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), aztreonam |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | cephalexin | 80 | 0.03 | 2.7 × 10³ | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), cephalexin |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | imipenem | — | — | 27 | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | imipenem | 0.001 | — | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C beta-lactamase (cephalosporinase) | Serratia marcescens | imipenem | — | 6 × 10⁻⁵ | — | pH 8.2 | Open record: class C beta-lactamase (cephalosporinase), imipenem |
| class C β-lactamase | Escherichia coli | cephaloridine | — | — | 1.3 × 10⁴ | pH 8.2 | Open record: class C β-lactamase, cephaloridine |
| class C β-lactamase | Pseudomonas aeruginosa | N-formimidoyl-thienamycin | — | 2.6 × 10⁻⁵ | — | Open record: class C β-lactamase, N-formimidoyl-thienamycin |