Values CatLog read from this paper

Cefepime-taniborbactam and ceftibuten-ledaborbactam maintain activity against KPC variants that lead to ceftazidime-avibactam resistance

PMID 39927783doi:10.1128/aac.01511-24Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 28 records (60 values) from this paper: KPC-2, KPC-3 from Klebsiella pneumoniae.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.5.2.6

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
KPC-2	Klebsiella pneumoniae	Cefepime	—	—	130	pH 7.4	Open record: KPC-2, Cefepime
KPC-2	Klebsiella pneumoniae	Ceftazidime	—	—	0.73	pH 7.4	Open record: KPC-2, Ceftazidime
KPC-2	Klebsiella pneumoniae	Ceftibuten	—	—	2.2	pH 7.4	Open record: KPC-2, Ceftibuten
KPC-2	Klebsiella pneumoniae	CENTA	243	0.0197	1.5 × 10⁴	pH 7.4	Open record: KPC-2, CENTA
KPC-2variant D179Y	Klebsiella pneumoniae	Cefepime	0.015	0.0037	4	pH 7.4	Open record: KPC-2 variant D179Y, Cefepime
KPC-2variant D179Y	Klebsiella pneumoniae	Ceftazidime	0.0012	6 × 10⁻⁴	2	pH 7.4	Open record: KPC-2 variant D179Y, Ceftazidime
KPC-2variant D179Y	Klebsiella pneumoniae	CENTA	0.012	0.0019	0.74	pH 7.4	Open record: KPC-2 variant D179Y, CENTA
KPC-2variant D179Y/T243M	Klebsiella pneumoniae	Cefepime	0.017	0.003	5.7	pH 7.4	Open record: KPC-2 variant D179Y/T243M, Cefepime
KPC-2variant D179Y/T243M	Klebsiella pneumoniae	Ceftazidime	0.0037	0.001	3.7	pH 7.4	Open record: KPC-2 variant D179Y/T243M, Ceftazidime
KPC-2variant D179Y/T243M	Klebsiella pneumoniae	CENTA	0.009	0.0021	550	pH 7.4	Open record: KPC-2 variant D179Y/T243M, CENTA
KPC-2variant V240G	Klebsiella pneumoniae	Cefepime	—	—	190	pH 7.4	Open record: KPC-2 variant V240G, Cefepime
KPC-2variant V240G	Klebsiella pneumoniae	Ceftazidime	—	—	0.8	pH 7.4	Open record: KPC-2 variant V240G, Ceftazidime
KPC-2variant V240G	Klebsiella pneumoniae	Ceftibuten	—	—	2	pH 7.4	Open record: KPC-2 variant V240G, Ceftibuten
KPC-2variant V240G	Klebsiella pneumoniae	CENTA	662	0.0633	4.1 × 10⁴	pH 7.4	Open record: KPC-2 variant V240G, CENTA
KPC-3	Klebsiella pneumoniae	Cefepime	—	—	42	pH 7.4	Open record: KPC-3, Cefepime
KPC-3	Klebsiella pneumoniae	Ceftazidime	—	—	2.3	pH 7.4	Open record: KPC-3, Ceftazidime
KPC-3	Klebsiella pneumoniae	Ceftibuten	—	—	0.95	pH 7.4	Open record: KPC-3, Ceftibuten
KPC-3	Klebsiella pneumoniae	CENTA	38	0.105	370	pH 7.4	Open record: KPC-3, CENTA
KPC-3variant D179Y	Klebsiella pneumoniae	Cefepime	38	0.09	420	pH 7.4	Open record: KPC-3 variant D179Y, Cefepime
KPC-3variant D179Y	Klebsiella pneumoniae	Ceftazidime	1.2	0.0155	79	pH 7.4	Open record: KPC-3 variant D179Y, Ceftazidime
KPC-3variant D179Y	Klebsiella pneumoniae	CENTA	0.24	0.124	1.2	pH 7.4	Open record: KPC-3 variant D179Y, CENTA
KPC-3variant D179Y/T243M	Klebsiella pneumoniae	Cefepime	18.7	0.0425	440	pH 7.4	Open record: KPC-3 variant D179Y/T243M, Cefepime
KPC-3variant D179Y/T243M	Klebsiella pneumoniae	Ceftazidime	1.6	0.0146	110	pH 7.4	Open record: KPC-3 variant D179Y/T243M, Ceftazidime
KPC-3variant D179Y/T243M	Klebsiella pneumoniae	CENTA	0.18	0.153	1.2	pH 7.4	Open record: KPC-3 variant D179Y/T243M, CENTA
KPC-3variant V240G	Klebsiella pneumoniae	Cefepime	—	—	42	pH 7.4	Open record: KPC-3 variant V240G, Cefepime
KPC-3variant V240G	Klebsiella pneumoniae	Ceftazidime	—	—	3.8	pH 7.4	Open record: KPC-3 variant V240G, Ceftazidime
KPC-3variant V240G	Klebsiella pneumoniae	Ceftibuten	—	—	1.3	pH 7.4	Open record: KPC-3 variant V240G, Ceftibuten
KPC-3variant V240G	Klebsiella pneumoniae	CENTA	12.7	0.0548	230	pH 7.4	Open record: KPC-3 variant V240G, CENTA