Values CatLog read from this paper

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in…

PMID 40067047doi:10.1128/msystems.00184-25Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 62 records (180 values) from this paper: KPC-15, KPC-16, KPC-2 and 7 more from Klebsiella pneumoniae.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.5.2.6

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
KPC-14	Klebsiella pneumoniae	aztreonam	2.8	0.192	14	pH 7, 37 °C	Open record: KPC-14, aztreonam
KPC-14	Klebsiella pneumoniae	cefazolin	27	0.287	94	pH 7, 37 °C	Open record: KPC-14, cefazolin
KPC-14	Klebsiella pneumoniae	cefepime	7.6	0.07	110	pH 7, 37 °C	Open record: KPC-14, cefepime
KPC-14	Klebsiella pneumoniae	ceftazidime	24	0.073	330	pH 7, 37 °C	Open record: KPC-14, ceftazidime
KPC-14	Klebsiella pneumoniae	imipenem	19	0.548	35	pH 7, 37 °C	Open record: KPC-14, imipenem
KPC-14	Klebsiella pneumoniae	piperacillin	1.08	0.045	23	pH 7, 37 °C	Open record: KPC-14, piperacillin
KPC-15	Klebsiella pneumoniae	aztreonam	16	0.336	6.7	pH 7, 37 °C	Open record: KPC-15, aztreonam
KPC-15	Klebsiella pneumoniae	cefazolin	51	0.645	460	pH 7, 37 °C	Open record: KPC-15, cefazolin
KPC-15	Klebsiella pneumoniae	cefepime	14	0.371	47	pH 7, 37 °C	Open record: KPC-15, cefepime
KPC-15	Klebsiella pneumoniae	ceftazidime	6.1	0.251	10	pH 7, 37 °C	Open record: KPC-15, ceftazidime
KPC-15	Klebsiella pneumoniae	imipenem	7.5	0.104	76	pH 7, 37 °C	Open record: KPC-15, imipenem
KPC-15	Klebsiella pneumoniae	meropenem	4.8	0.168	300	pH 7, 37 °C	Open record: KPC-15, meropenem
KPC-15	Klebsiella pneumoniae	piperacillin	1.8	0.086	2.2	pH 7, 37 °C	Open record: KPC-15, piperacillin
KPC-16	Klebsiella pneumoniae	aztreonam	7.7	0.76	3.2	pH 7, 37 °C	Open record: KPC-16, aztreonam
KPC-16	Klebsiella pneumoniae	cefazolin	72	0.253	660	pH 7, 37 °C	Open record: KPC-16, cefazolin
KPC-16	Klebsiella pneumoniae	cefepime	2.3	0.053	16	pH 7, 37 °C	Open record: KPC-16, cefepime
KPC-16	Klebsiella pneumoniae	ceftazidime	0.04	0.39	0.07	pH 7, 37 °C	Open record: KPC-16, ceftazidime
KPC-16	Klebsiella pneumoniae	imipenem	12	0.053	130	pH 7, 37 °C	Open record: KPC-16, imipenem
KPC-16	Klebsiella pneumoniae	meropenem	1.9	0.013	120	pH 7, 37 °C	Open record: KPC-16, meropenem
KPC-16	Klebsiella pneumoniae	piperacillin	4.1	0.765	5.2	pH 7, 37 °C	Open record: KPC-16, piperacillin
KPC-2	Klebsiella pneumoniae	aztreonam	12.6	2.398	5	pH 7, 37 °C	Open record: KPC-2, aztreonam
KPC-2	Klebsiella pneumoniae	cefazolin	65	0.11	590	pH 7, 37 °C	Open record: KPC-2, cefazolin
KPC-2	Klebsiella pneumoniae	cefepime	4.7	0.31	15	pH 7, 37 °C	Open record: KPC-2, cefepime
KPC-2	Klebsiella pneumoniae	ceftazidime	3.27	0.59	5.5	pH 7, 37 °C	Open record: KPC-2, ceftazidime
KPC-2	Klebsiella pneumoniae	imipenem	28	0.098	290	pH 7, 37 °C	Open record: KPC-2, imipenem
KPC-2	Klebsiella pneumoniae	meropenem	8	0.016	500	pH 7, 37 °C	Open record: KPC-2, meropenem
KPC-2	Klebsiella pneumoniae	piperacillin	7.7	0.793	9.7	pH 7, 37 °C	Open record: KPC-2, piperacillin
KPC-21	Klebsiella pneumoniae	aztreonam	1.7	0.283	0.71	pH 7, 37 °C	Open record: KPC-21, aztreonam
KPC-21	Klebsiella pneumoniae	cefazolin	12	0.437	11	pH 7, 37 °C	Open record: KPC-21, cefazolin
KPC-21	Klebsiella pneumoniae	cefepime	3	0.277	9.6	pH 7, 37 °C	Open record: KPC-21, cefepime
KPC-21	Klebsiella pneumoniae	imipenem	1.8	0.019	18	pH 7, 37 °C	Open record: KPC-21, imipenem
KPC-21	Klebsiella pneumoniae	meropenem	10	0.048	610	pH 7, 37 °C	Open record: KPC-21, meropenem
KPC-25	Klebsiella pneumoniae	cefazolin	7.3	0.073	65	pH 7, 37 °C	Open record: KPC-25, cefazolin
KPC-25	Klebsiella pneumoniae	meropenem	4	3.783	250	pH 7, 37 °C	Open record: KPC-25, meropenem
KPC-28	Klebsiella pneumoniae	aztreonam	28	—	12	pH 7, 37 °C	Open record: KPC-28, aztreonam
KPC-28	Klebsiella pneumoniae	cefazolin	14	0.68	130	pH 7, 37 °C	Open record: KPC-28, cefazolin
KPC-28	Klebsiella pneumoniae	cefepime	22	0.115	70	pH 7, 37 °C	Open record: KPC-28, cefepime
KPC-28	Klebsiella pneumoniae	ceftazidime	6.1	0.28	10	pH 7, 37 °C	Open record: KPC-28, ceftazidime
KPC-28	Klebsiella pneumoniae	imipenem	3.8	0.563	39	pH 7, 37 °C	Open record: KPC-28, imipenem
KPC-28	Klebsiella pneumoniae	meropenem	4.1	—	260	pH 7, 37 °C	Open record: KPC-28, meropenem
KPC-28	Klebsiella pneumoniae	piperacillin	1.5	0.061	1.9	pH 7, 37 °C	Open record: KPC-28, piperacillin
KPC-3	Klebsiella pneumoniae	aztreonam	7.9	0.221	36	pH 7, 37 °C	Open record: KPC-3, aztreonam
KPC-3	Klebsiella pneumoniae	cefazolin	61	0.368	170	pH 7, 37 °C	Open record: KPC-3, cefazolin
KPC-3	Klebsiella pneumoniae	cefepime	4.5	0.512	8.9	pH 7, 37 °C	Open record: KPC-3, cefepime
KPC-3	Klebsiella pneumoniae	ceftazidime	2.7	0.233	11	pH 7, 37 °C	Open record: KPC-3, ceftazidime
KPC-3	Klebsiella pneumoniae	imipenem	33	0.064	520	pH 7, 37 °C	Open record: KPC-3, imipenem
KPC-3	Klebsiella pneumoniae	meropenem	5.7	0.024	230	pH 7, 37 °C	Open record: KPC-3, meropenem
KPC-3	Klebsiella pneumoniae	piperacillin	5.2	1.097	4.8	pH 7, 37 °C	Open record: KPC-3, piperacillin
KPC-31	Klebsiella pneumoniae	aztreonam	9.1	—	3.8	pH 7, 37 °C	Open record: KPC-31, aztreonam
KPC-31	Klebsiella pneumoniae	cefazolin	1.3	0.142	11	pH 7, 37 °C	Open record: KPC-31, cefazolin
KPC-31	Klebsiella pneumoniae	cefepime	3.2	—	10	pH 7, 37 °C	Open record: KPC-31, cefepime
KPC-31	Klebsiella pneumoniae	ceftazidime	4.7	1.737	7.9	pH 7, 37 °C	Open record: KPC-31, ceftazidime
KPC-31	Klebsiella pneumoniae	imipenem	7.7	3.508	78	pH 7, 37 °C	Open record: KPC-31, imipenem
KPC-31	Klebsiella pneumoniae	meropenem	1.1	—	68	pH 7, 37 °C	Open record: KPC-31, meropenem
KPC-31	Klebsiella pneumoniae	piperacillin	1.02	—	1.3	pH 7, 37 °C	Open record: KPC-31, piperacillin
KPC-4	Klebsiella pneumoniae	aztreonam	15	0.763	6.4	pH 7, 37 °C	Open record: KPC-4, aztreonam
KPC-4	Klebsiella pneumoniae	cefazolin	59	0.113	540	pH 7, 37 °C	Open record: KPC-4, cefazolin
KPC-4	Klebsiella pneumoniae	cefepime	16	0.277	53	pH 7, 37 °C	Open record: KPC-4, cefepime
KPC-4	Klebsiella pneumoniae	ceftazidime	5.4	0.213	9.1	pH 7, 37 °C	Open record: KPC-4, ceftazidime
KPC-4	Klebsiella pneumoniae	imipenem	22	0.096	230	pH 7, 37 °C	Open record: KPC-4, imipenem
KPC-4	Klebsiella pneumoniae	meropenem	6.6	0.016	410	pH 7, 37 °C	Open record: KPC-4, meropenem
KPC-4	Klebsiella pneumoniae	piperacillin	6.6	0.231	8.4	pH 7, 37 °C	Open record: KPC-4, piperacillin