CatLogenzyme kinetics catalog

Values CatLog read from this paper

Reduced catalytic activity of KPC β-lactamase can increase ceftazidime resistance

PMID 41946819doi:10.1038/s42003-026-09969-1Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 20 records (58 values) from this paper: KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase) from Klebsiella pneumoniae.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 3.5.2.6

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant D179Y (KPC-33)Klebsiella pneumoniaecephalothin0.050.0077pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant D179Y (KPC-33)Klebsiella pneumoniaeimipenem0.0030.0930.032pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant D179Y/H274Y (KPC-31)Klebsiella pneumoniaecephalothin0.060.003517pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant D179Y/H274Y (KPC-31)Klebsiella pneumoniaeimipenem0.0030.0440.068pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M (KPC-100)Klebsiella pneumoniaeceftazidime9.20.5815pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M (KPC-100)Klebsiella pneumoniaecephalothin900.0372.4 × 10³pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M (KPC-100)Klebsiella pneumoniaeimipenem5.90.056100pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M (KPC-100)Klebsiella pneumoniaenitrocefin640.0183.6 × 10³pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y (KPC-128)Klebsiella pneumoniaeceftazidime0.0110.00761.5pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y (KPC-128)Klebsiella pneumoniaecephalothin0.050.00413pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y (KPC-128)Klebsiella pneumoniaeimipenem0.0010.1570.0064pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y (KPC-128)Klebsiella pneumoniaenitrocefin0.080.00516pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y/H274Y (KPC-32)Klebsiella pneumoniaeceftazidime0.0130.01760.74pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y/H274Y (KPC-32)Klebsiella pneumoniaecephalothin0.090.0194pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y/H274Y (KPC-32)Klebsiella pneumoniaeimipenem0.0060.0480.12pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/D179Y/H274Y (KPC-32)Klebsiella pneumoniaenitrocefin0.0330.0132.5pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/H274Y (KPC-89)Klebsiella pneumoniaeceftazidime——7.6pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/H274Y (KPC-89)Klebsiella pneumoniaecephalothin700.0531.3 × 10³pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/H274Y (KPC-89)Klebsiella pneumoniaeimipenem3.30.013260pH 7, 25 °COpen
KPC-2 beta-lactamase (Klebsiella pneumoniae carbapenemase)variant T243M/H274Y (KPC-89)Klebsiella pneumoniaenitrocefin300.00773.9 × 10³pH 7, 25 °COpen