CatLogenzyme kinetics catalog

Values CatLog read from this paper

Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase

PMID 41999896doi:10.1016/j.jbc.2026.111457Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 14 records (28 values) from this paper: SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complex from SARS-CoV-2.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2ATPtemplating base A; incoming ATP (A:ATP misincorporation)—0.9—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2ATPtemplating base C; incoming ATP (C:ATP misincorporation)0.0050.150.03pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2ATPtemplating base G; incoming ATP (G:ATP misincorporation)—1.1—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2cytidine triphosphatetemplating base A; incoming CTP (A:CTP misincorporation)0.0030.30.012pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2cytidine triphosphatetemplating base C; incoming CTP (C:CTP misincorporation)—1.4—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2cytidine triphosphatetemplating base G6000.0659.2 × 10³pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2cytidine triphosphatetemplating base U; incoming CTP (U:CTP misincorporation)—2.2—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2guanosine triphosphatetemplating base A; incoming GTP (A:GTP misincorporation)—3.1—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2guanosine triphosphatetemplating base C4200.094.7 × 10³pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2guanosine triphosphatetemplating base G; incoming GTP (G:GTP misincorporation)0.0020.1310.02pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2guanosine triphosphatetemplating base U; incoming GTP (U:GTP misincorporation)0.440.1pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2UTPtemplating base C; incoming UTP (C:UTP misincorporation)—0.13—pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2UTPtemplating base G; incoming UTP (G:UTP misincorporation)0.0060.160.04pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/7/8 complexSARS-CoV-2UTPtemplating base U; incoming UTP (U:UTP misincorporation)—0.11—pH 7, 37 °COpen