CatLogenzyme kinetics catalog

Values CatLog read from this paper

Improved hydrolysis of piperacillin by OXA-48-like R214G variants, a selective advantage under piperacillin-tazobactam exposure

PMID 42053451doi:10.1128/aac.01267-25Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 24 records (72 values) from this paper: OXA-181, OXA-232 (OXA-181 R214S), OXA-244 (OXA-48 R214G) and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
OXA-181—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO31830.1041759pH 7.4, 30 °COpen
OXA-181—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO32420.1082236pH 7.4, 30 °COpen
OXA-181—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3480.214224pH 7.4, 30 °COpen
OXA-181—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO32840.337849pH 7.4, 30 °COpen
OXA-232 (OXA-181 R214S)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO31950.1161687pH 7.4, 30 °COpen
OXA-232 (OXA-181 R214S)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO34540.1433192pH 7.4, 30 °COpen
OXA-232 (OXA-181 R214S)—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO31680.214786pH 7.4, 30 °COpen
OXA-232 (OXA-181 R214S)—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO34310.3221382pH 7.4, 30 °COpen
OXA-244 (OXA-48 R214G)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3870.138639pH 7.4, 30 °COpen
OXA-244 (OXA-48 R214G)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO31880.206929pH 7.4, 30 °COpen
OXA-244 (OXA-48 R214G)—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3750.131576pH 7.4, 30 °COpen
OXA-244 (OXA-48 R214G)—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO31220.16765pH 7.4, 30 °COpen
OXA-48—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO31090.111980pH 7.4, 30 °COpen
OXA-48—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO31930.1771.1 × 10³pH 7.4, 30 °COpen
OXA-48—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3330.37393pH 7.4, 30 °COpen
OXA-48—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO31610.348463pH 7.4, 30 °COpen
OXA-484 (OXA-181 R214G)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO31800.1081.66 × 10³pH 7.4, 30 °COpen
OXA-484 (OXA-181 R214G)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO32140.1141885pH 7.4, 30 °COpen
OXA-484 (OXA-181 R214G)—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3740.123605pH 7.4, 30 °COpen
OXA-484 (OXA-181 R214G)—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO32320.1012345pH 7.4, 30 °COpen
OXA-933 (OXA-48 D159N)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO32780.284981pH 7.4, 30 °COpen
OXA-933 (OXA-48 D159N)—benzylpenicillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO31860.1081714pH 7.4, 30 °COpen
OXA-933 (OXA-48 D159N)—piperacillin100 mM sodium phosphate buffer (pH 7.4); no NaHCO3690.223316pH 7.4, 30 °COpen
OXA-933 (OXA-48 D159N)—piperacillin100 mM sodium phosphate buffer (pH 7.4) with 25 mM NaHCO32060.396510pH 7.4, 30 °COpen