Values CatLog read from this paper
A Potent and Selective Quinolone-Based PTPN22 Inhibitor with Improved Immunotherapeutic Activity
PMID 42388138doi:10.1021/acs.jmedchem.5c03467Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 4 records (8 values) from this paper: PTPN22 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 4 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| PTPN22 | Homo sapiens | para-nitrophenyl phosphate | 1.17 | 5.62 | 0.208 calc. | pH 7 | Open record: PTPN22, para-nitrophenyl phosphate |
| PTPN22variant K136R | Homo sapiens | para-nitrophenyl phosphate | 1.75 | 4.4 | 0.40 calc. | pH 7 | Open record: PTPN22 variant K136R, para-nitrophenyl phosphate |
| PTPN22variant K136S | Homo sapiens | para-nitrophenyl phosphate | 1.72 | 6.46 | 0.266 calc. | pH 7 | Open record: PTPN22 variant K136S, para-nitrophenyl phosphate |
| PTPN22variant K138A | Homo sapiens | para-nitrophenyl phosphate | 2.54 | 7.3 | 0.35 calc. | pH 7 | Open record: PTPN22 variant K138A, para-nitrophenyl phosphate |