Values CatLog read from this paper
Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases
PMID 42455676doi:10.1073/pnas.2611077123Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 9 records (21 values) from this paper: EstX_Ec (macrolide esterase EstX), EstT_Sf (macrolide esterase EstT) from Escherichia coli, Sphingobacterium faecium.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| EstT_Sf (macrolide esterase EstT) | Sphingobacterium faecium | tilmicosin | 12 | — | — | pH 7 | Open record: EstT_Sf (macrolide esterase EstT), tilmicosin |
| EstT_Sf (macrolide esterase EstT) | Sphingobacterium faecium | tylosin | 5.1 | 0.015 | 340 | pH 7 | Open record: EstT_Sf (macrolide esterase EstT), tylosin |
| EstX_Ec (macrolide esterase EstX) | Escherichia coli | tilmicosin | 5 × 10⁻⁴ | — | — | pH 7 | Open record: EstX_Ec (macrolide esterase EstX), tilmicosin |
| EstX_Ec (macrolide esterase EstX) | Escherichia coli | tylosin | 1.33 | 0.02 | 66 | pH 7 | Open record: EstX_Ec (macrolide esterase EstX), tylosin |
| EstX_Ec (macrolide esterase EstX)variant E128G | Escherichia coli | tilmicosin | 0.0059 | — | — | pH 7 | Open record: EstX_Ec (macrolide esterase EstX) variant E128G, tilmicosin |
| EstX_Ec (macrolide esterase EstX)variant E128G | Escherichia coli | tylosin | 0.76 | 0.021 | 36 | pH 7 | Open record: EstX_Ec (macrolide esterase EstX) variant E128G, tylosin |
| EstX_Ec (macrolide esterase EstX)variant W38Y/Q166L/N192E | Escherichia coli | tylosin | 18.1 | 0.053 | 340 | pH 7 | Open record: EstX_Ec (macrolide esterase EstX) variant W38Y/Q166L/N192E, tylosin |
| EstX_Ec (macrolide esterase EstX)variant W38Y/Q166L/W170A/N192E | Escherichia coli | tylosin | 21.6 | 0.057 | 380 | pH 7 | Open record: EstX_Ec (macrolide esterase EstX) variant W38Y/Q166L/W170A/N192E, tylosin |
| EstX_Ec (macrolide esterase EstX)variant W39Y/Q166L/N192E | Escherichia coli | tylosin | 19.3 | 0.055 | 350 | pH 7 | Open record: EstX_Ec (macrolide esterase EstX) variant W39Y/Q166L/N192E, tylosin |